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<DescriptorRecordSet LanguageCode = "eng">
<DescriptorRecord DescriptorClass = "1">
  <DescriptorUI>D012900</DescriptorUI>
  <DescriptorName>
   <String>Smallpox Vaccine</String>
  </DescriptorName>
  <DateCreated>
   <Year>1999</Year>
   <Month>01</Month>
   <Day>01</Day>
  </DateCreated>
  <DateRevised>
   <Year>2022</Year>
   <Month>08</Month>
   <Day>11</Day>
  </DateRevised>
  <DateEstablished>
   <Year>1966</Year>
   <Month>01</Month>
   <Day>01</Day>
  </DateEstablished>
  <AllowableQualifiersList>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000302</QualifierUI>
      <QualifierName>
      <String>isolation &amp; purification</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>IP</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000276</QualifierUI>
      <QualifierName>
      <String>immunology</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>IM</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000493</QualifierUI>
      <QualifierName>
      <String>pharmacokinetics</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>PK</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000096</QualifierUI>
      <QualifierName>
      <String>biosynthesis</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>BI</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000627</QualifierUI>
      <QualifierName>
      <String>therapeutic use</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>TU</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000819</QualifierUI>
      <QualifierName>
      <String>agonists</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>AG</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000097</QualifierUI>
      <QualifierName>
      <String>blood</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>BL</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000134</QualifierUI>
      <QualifierName>
      <String>cerebrospinal fluid</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>CF</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000138</QualifierUI>
      <QualifierName>
      <String>chemical synthesis</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>CS</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000737</QualifierUI>
      <QualifierName>
      <String>chemistry</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>CH</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000652</QualifierUI>
      <QualifierName>
      <String>urine</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>UR</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000528</QualifierUI>
      <QualifierName>
      <String>radiation effects</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>RE</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000266</QualifierUI>
      <QualifierName>
      <String>history</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>HI</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000032</QualifierUI>
      <QualifierName>
      <String>analysis</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>AN</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000145</QualifierUI>
      <QualifierName>
      <String>classification</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>CL</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000191</QualifierUI>
      <QualifierName>
      <String>economics</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>EC</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000235</QualifierUI>
      <QualifierName>
      <String>genetics</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>GE</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000494</QualifierUI>
      <QualifierName>
      <String>pharmacology</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>PD</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000592</QualifierUI>
      <QualifierName>
      <String>standards</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>ST</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000008</QualifierUI>
      <QualifierName>
      <String>administration &amp; dosage</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>AD</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000037</QualifierUI>
      <QualifierName>
      <String>antagonists &amp; inhibitors</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>AI</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000600</QualifierUI>
      <QualifierName>
      <String>supply &amp; distribution</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>SD</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000506</QualifierUI>
      <QualifierName>
      <String>poisoning</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>PO</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000009</QualifierUI>
      <QualifierName>
      <String>adverse effects</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>AE</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000633</QualifierUI>
      <QualifierName>
      <String>toxicity</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>TO</Abbreviation>
   </AllowableQualifier>
   <AllowableQualifier>
    <QualifierReferredTo>
     <QualifierUI>Q000378</QualifierUI>
      <QualifierName>
      <String>metabolism</String>
      </QualifierName>
    </QualifierReferredTo>
    <Abbreviation>ME</Abbreviation>
   </AllowableQualifier>
  </AllowableQualifiersList>
  <TreeNumberList>
   <TreeNumber>D20.215.894.899.859</TreeNumber>
  </TreeNumberList>
  <ConceptList>
   <Concept PreferredConceptYN="Y">
    <ConceptUI>M0019978</ConceptUI>
    <ConceptName>
     <String>Smallpox Vaccine</String>
    </ConceptName>
    <RegistryNumber>0</RegistryNumber>
    <ScopeNote>A VACCINIA VIRUS vaccine used for immunization against SMALLPOX. It is now recommended only for laboratory workers exposed to SMALLPOX VIRUS. Certain countries continue to vaccinate those in the military service. Rare complications most often associated with older generation smallpox vaccines include VACCINIA, secondary bacterial infections, and ENCEPHALOMYELITIS. Because MONKEYPOX VIRUS and SMALLPOX VIRUS are both ORTHOPOXVIRUS and are closely related smallpox vaccines provide effective CROSS-PROTECTION against MONKEYPOX (https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html).
    </ScopeNote>
    <ConceptRelationList>
     <ConceptRelation RelationName="REL">
     <Concept1UI>M0019978</Concept1UI>
     <Concept2UI>M000758087</Concept2UI>
     </ConceptRelation>
     <ConceptRelation RelationName="REL">
     <Concept1UI>M0019978</Concept1UI>
     <Concept2UI>M000758088</Concept2UI>
     </ConceptRelation>
     <ConceptRelation RelationName="REL">
     <Concept1UI>M0019978</Concept1UI>
     <Concept2UI>M000758086</Concept2UI>
     </ConceptRelation>
    </ConceptRelationList>
    <TermList>
     <Term  ConceptPreferredTermYN="Y"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="Y">
      <TermUI>T038020</TermUI>
      <String>Smallpox Vaccine</String>
      <DateCreated>
       <Year>1999</Year>
       <Month>01</Month>
       <Day>01</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (1966)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="Y"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T038020</TermUI>
      <String>Vaccine, Smallpox</String>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123416</TermUI>
      <String>Small Pox Vaccine</String>
      <DateCreated>
       <Year>2022</Year>
       <Month>08</Month>
       <Day>11</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (2023)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="Y"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123416</TermUI>
      <String>Vaccine, Small Pox</String>
     </Term>
    </TermList>
   </Concept>
   <Concept PreferredConceptYN="N">
    <ConceptUI>M000758087</ConceptUI>
    <ConceptName>
     <String>Vaccinia Vaccine</String>
    </ConceptName>
    <RegistryNumber>0</RegistryNumber>
    <ConceptRelationList>
     <ConceptRelation RelationName="REL">
     <Concept1UI>M0019978</Concept1UI>
     <Concept2UI>M000758087</Concept2UI>
     </ConceptRelation>
    </ConceptRelationList>
    <TermList>
     <Term  ConceptPreferredTermYN="Y"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123375</TermUI>
      <String>Vaccinia Vaccine</String>
      <DateCreated>
       <Year>2022</Year>
       <Month>08</Month>
       <Day>11</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (2023)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="Y"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123375</TermUI>
      <String>Vaccine, Vaccinia</String>
     </Term>
    </TermList>
   </Concept>
   <Concept PreferredConceptYN="N">
    <ConceptUI>M000758088</ConceptUI>
    <ConceptName>
     <String>Monkeypox Vaccine</String>
    </ConceptName>
    <RegistryNumber>0</RegistryNumber>
    <ConceptRelationList>
     <ConceptRelation RelationName="REL">
     <Concept1UI>M0019978</Concept1UI>
     <Concept2UI>M000758088</Concept2UI>
     </ConceptRelation>
    </ConceptRelationList>
    <TermList>
     <Term  ConceptPreferredTermYN="Y"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123376</TermUI>
      <String>Monkeypox Vaccine</String>
      <DateCreated>
       <Year>2022</Year>
       <Month>08</Month>
       <Day>11</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (2023)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="Y"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123376</TermUI>
      <String>Vaccine, Monkeypox</String>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123417</TermUI>
      <String>Monkey Pox Vaccine</String>
      <DateCreated>
       <Year>2022</Year>
       <Month>08</Month>
       <Day>11</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (2023)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="Y"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123417</TermUI>
      <String>Vaccine, Monkey Pox</String>
     </Term>
    </TermList>
   </Concept>
   <Concept PreferredConceptYN="N">
    <ConceptUI>M000758086</ConceptUI>
    <ConceptName>
     <String>Smallpox and Monkeypox Vaccine</String>
    </ConceptName>
    <RegistryNumber>0</RegistryNumber>
    <ConceptRelationList>
     <ConceptRelation RelationName="REL">
     <Concept1UI>M0019978</Concept1UI>
     <Concept2UI>M000758086</Concept2UI>
     </ConceptRelation>
    </ConceptRelationList>
    <TermList>
     <Term  ConceptPreferredTermYN="Y"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123373</TermUI>
      <String>Smallpox and Monkeypox Vaccine</String>
      <DateCreated>
       <Year>2022</Year>
       <Month>08</Month>
       <Day>11</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (2023)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
     <Term  ConceptPreferredTermYN="N"  IsPermutedTermYN="N"  LexicalTag="NON"  RecordPreferredTermYN="N">
      <TermUI>T001123377</TermUI>
      <String>Monkeypox and Smallpox Vaccine</String>
      <DateCreated>
       <Year>2022</Year>
       <Month>08</Month>
       <Day>11</Day>
      </DateCreated>
      <ThesaurusIDlist>
       <ThesaurusID>NLM (2023)</ThesaurusID>
      </ThesaurusIDlist>
     </Term>
    </TermList>
   </Concept>
  </ConceptList>
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