MH - Abatacept UI - D000069594 MN - D12.776.124.486.485.114.580.225 MN - D12.776.124.790.651.114.580.225 MN - D12.776.377.715.548.114.580.225 MS - A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS. HN - 2016 (2002) MH - Abiraterone Acetate UI - D000069501 MN - D4.808.54.79.65 MS - An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER. HN - 2016 (1994) MH - Abnormal Involuntary Movement Scale UI - D000067399 MN - E1.370.600.550.162 MS - A rating scale that measures INVOLUNTARY MOVEMENTS known as TARDIVE DYSKINESIA. HN - 2016 MH - Acne Conglobata UI - D000069316 MN - C17.800.30.150.500 MN - C17.800.794.111.500 MS - Severe and chronic form of acne characterized by large, burrowing abscesses associated with disfigurement. HN - 2016 MH - Action Spectrum UI - D000067549 MN - E5.196.867.826.150 MS - A technique used to measure the rate of physiological activity plotted against wavelength of light. An action spectrum depicts the most effective wavelength of light (also known as spectral sensitivity) that is required for each specific process. HN - 2016 MH - Adalimumab UI - D000068879 MN - D12.776.124.486.485.114.224.60.250 MN - D12.776.124.790.651.114.224.60.250 MN - D12.776.377.715.548.114.224.200.250 MS - A humanized monoclonal antibody that binds specifically to TNF-ALPHA and blocks its interaction with endogenous TNF RECEPTORS to modulate INFLAMMATION. It is used in the treatment of RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS; CROHN'S DISEASE and ULCERATIVE COLITIS. HN - 2016 (2002) MH - Adapalene UI - D000068816 MN - D2.455.426.559.847.638.90 MN - D4.615.638.90 MS - A naphthalene derivative that has specificity for RETINOIC ACID RECEPTORS. It is used as a DERMATOLOGIC AGENT for the treatment of ACNE. HN - 2016 (1990) MH - Adapalene, Benzoyl Peroxide Drug Combination UI - D000068801 MN - D2.241.223.100.133.500 MN - D2.455.426.559.389.127.133.500 MN - D2.455.426.559.847.638.90.500 MN - D4.615.638.90.500 MN - D26.310.32 MS - A pharmaceutical preparation of adapalene and benzoyl peroxide that is used as a DERMATOLOGIC AGENT for the topical treatment of ACNE. HN - 2016 MH - Adenylyl Cyclase Inhibitors UI - D000067956 MN - D27.505.519.389.108 MS - Compounds that bind to and inhibit the action of ADENYLYL CYCLASES. HN - 2016 MH - Administrative Claims, Healthcare UI - D000067575 MN - N4.452.859.564.137 MS - Information relating to itemized coding of procedures and costs associated with healthcare delivery, used as a means for tracking healthcare utilization, patterns of care, and treatment outcomes. HN - 2016 MH - Adolescent Health UI - D000067697 MN - N1.400.75 MS - The concept covering the physical and mental conditions of ADOLESCENTS. HN - 2016 FX - Adolescent Health Services FX - Adolescent Medicine MH - Adult Day Care Centers UI - D000069537 MN - N2.421.143.65 MS - Non-residential facilities that are designed to provide care and companionship for seniors who need assistance or supervision during the day. HN - 2016 FX - Senior Centers MH - Adult Survivors of Child Adverse Events UI - D000069586 MN - M1.860.300 MS - Persons who experienced traumatic events during childhood. HN - 2016 MH - Advanced Glycosylation End Product-Specific Receptor UI - D000067759 MN - D12.776.543.750.06 MS - A single-pass transmembrane CELL SURFACE RECEPTOR that binds ADVANCED GLYCOSYLATION END PRODUCTS to mediate cellular responses to both acute and chronic vascular inflammation in conditions such as ATHEROSCLEROSIS and DIABETES MELLITUS, TYPE 2 . It also binds AMYLOID BETA PEPTIDES and the alarmins S100A12 and S100 CALCIUM BINDING PROTEIN BETA SUBUNIT. HN - 2016 (1991) MH - African Union UI - D000068516 MN - I1.615.500.125 MN - N3.540.89 MS - A geopolitical organization of African nations with a mission to integrate vital interests, promote international relations, political stability, and economic development among member states. AN - Cataloger: Use NAF entry HN - 2016 MH - Alarmins UI - D000067531 MN - D12.644.276.87 MN - D12.776.467.87 MN - D23.529.87 MS - A structurally diverse group of endogenous molecules that includes the HMGB1 PROTEIN; S100 PROTEINS; HSP60, Hsp70, Cathelicidin, IL-33, and DEFENSINS. They are constitutively available, released upon tissue damage, and activate the immune system. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis. HN - 2016 MH - Albumin-Bound Paclitaxel UI - D000068196 MN - D2.455.426.392.368.242.888.777.500 MN - D2.455.849.291.850.777.500 MN - D12.776.34.73 MS - An injectable formulation of albumin-bound paclitaxel NANOPARTICLES. HN - 2016 (2002) MH - Albuterol, Ipratropium Drug Combination UI - D000068600 MN - D2.33.100.291.57.125 MN - D2.92.63.291.57.125 MN - D2.92.471.683.61.125 MN - D2.145.74.722.229.400.500 MN - D3.132.760.180.572.400.500 MN - D3.132.889.180.648.400.500 MN - D3.605.869.229.400.500 MN - D4.75.80.875.99.722.229.400.500 MN - D26.310.344 MS - A combined pharmaceutical preparation of Ipratropium Bromide and Albuterol Sulfate that is used to treat the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE. HN - 2016 (1999) MH - Alcohol Drinking in College UI - D000067292 MN - F1.145.317.269.625 MS - Alcohol consumption among college students. HN - 2016 FX - Underage Drinking MH - Amlodipine Besylate, Olmesartan Medoxomil Drug Combination UI - D000068558 MN - D3.383.129.308.674.500 MN - D3.383.129.617.584.500 MN - D3.383.725.203.65.500 MN - D26.310.63 MS - A pharmaceutical preparation of amlodipine besylate and olmesartan medoxomil that combines ANGIOTENSIN II TYPE I RECEPTOR ANTAGONIST and CALCIUM CHANNEL BLOCKER activities. It is used in the management of HYPERTENSION. HN - 2016 MH - Amlodipine, Valsartan Drug Combination UI - D000068838 MN - D3.383.129.617.850.500 MN - D3.383.725.203.65.750 MN - D12.125.70.950.550.500 MN - D12.125.142.930.500.500 MN - D26.310.94 MS - A pharmaceutical preparation of amlodipine and valsartan that is used for the treatment of HYPERTENSION. HN - 2016 (2008) MH - Anger Management Therapy UI - D000067449 MN - F4.754.137.87 MS - System of psychological and/or therapeutic techniques used to control and or reduce the triggers, degrees, and effects of ANGER. HN - 2016 MH - Animals, Exotic UI - D000068881 MN - B1.50.50.126 MS - Animals native to a foreign country or of foreign origin or character, that are not native to the United States. AN - use only when specified by author; coordinate with ANIMALS, WILD or ANIMALS, ZOO as needed HN - 2016 MH - Aripiprazole UI - D000068180 MN - D3.383.606.170 MN - D3.438.810.835.122 MS - An antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. HN - 2016 (1995) MH - Armed Conflicts UI - D000068337 MN - I1.880.735.950.250 MS - Any differences arising between two nations or groups and leading to the intervention of armed forces. HN - 2016 MH - Arterial Switch Operation UI - D000069278 MN - E4.100.376.31 MN - E4.928.220.55 MS - Surgical procedure for anatomical correction of transposed great arteries (e.g., DOUBLE OUTLET RIGHT VENTRICLE). HN - 2016 FX - Transposition of Great Vessels MH - Arthrocentesis UI - D000069237 MN - E1.370.225.998.329.465 MN - E2.800.550.310 MN - E4.665.600.465 MN - E5.200.998.329.465 MS - Puncture and aspiration of fluid (e.g., SYNOVIAL FLUID) from a joint cavity. It is used sometimes to irrigate or administer drugs into a joint cavity. HN - 2016 MH - Aspirin, Dipyridamole Drug Combination UI - D000068342 MN - D2.455.426.559.389.657.410.595.176.500 MN - D3.383.742.175.500 MN - D26.310.125 MS - A drug combination of aspirin and dipyridamole that functions as a PLATELET AGGREGATION INHIBITOR, used to prevent THROMBOSIS and STROKE in TRANSIENT ISCHEMIC ATTACK patients. HN - 2016 (1986) MH - Ataxin-1 UI - D000067696 MN - D12.776.641.69.500 MN - D12.776.660.75.500 MS - A chromatin-binding factor that represses Notch signaling and associates with RNA. Expansion of the polyglutamine tract by expanded CAG repeats in the ATXN1 gene coding region is associated with SPINOCEREBELLAR ATAXIA 1. HN - 2016 (1995) FX - Spinocerebellar Ataxias MH - Ataxin-10 UI - D000067736 MN - D12.776.641.69.950 MS - An ataxin that is associated with the survival of cerebellar neurons. Expansion of the ATTCT pentanucleotide in the ATXN10 coding region is associated with SPINOCEREBELLAR ATAXIA 10. HN - 2016 MH - Ataxin-2 UI - D000067698 MN - D12.776.157.725.452.125 MN - D12.776.641.69.750 MN - D12.776.660.75.750 MN - D12.776.664.962.452.125 MS - A Poly(A) RNA-binding protein that negatively regulates EGFR ENDOCYTOSIS. An increased risk for developing AMYOTROPHIC LATERAL SCLEROSIS 13 is observed in patients who have more than 23 CAG repeats in the ATXN2 gene coding sequence. Larger CAG expansions in the ATXN2 gene occur in SPINOCEREBELLAR ATAXIA 2 patients. HN - 2016; use SCA2 PROTEIN (NM) 1996-2015 FX - Spinocerebellar Ataxias MH - Ataxin-3 UI - D000067699 MN - D8.811.277.656.300.887.500 MN - D12.776.641.69.875 MN - D12.776.660.75.875 MS - A DEUBIQUITINASE involved in protein homeostasis, transcription, cytoskeleton regulation, and myogenesis. It also acts as a histone-binding protein that represses transcription. CAG repeat expansions in the ATXN3 gene coding region are associated with SPINOCEREBELLAR ATAXIA 3 (SCA3). HN - 2016 (1995) FX - Spinocerebellar Ataxias MH - Ataxin-7 UI - D000067719 MN - D12.776.641.69.901 MN - D12.776.660.75.900 MS - A component of the STAGA transcription coactivator-HAT complex that functions in Cone Rod Homeobox Protein (CRX)-dependent gene activation. It also stabilizes MICROTUBULES. CAG repeat expansion in the ATXN-7 coding region is associated with the development of SPINOCEREBELLAR ATAXIA 7. HN - 2016 FX - Spinocerebellar Ataxias MH - Ataxins UI - D000067528 MN - D12.776.641.69 MN - D12.776.660.75 MS - A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset. HN - 2016 FX - Spinocerebellar Ataxias MH - Atazanavir Sulfate UI - D000069446 MN - D3.383.725.68 MN - D12.644.456.157 MS - An azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. HN - 2016 (2000) MH - Atomoxetine Hydrochloride UI - D000069445 MN - D2.92.831.85 MS - A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. HN - 2016 (1984) MH - Atorvastatin Calcium UI - D000069059 MN - D3.383.129.578.75 MN - D10.251.450.200 MS - A pyrrole and heptanoic acid derivative,HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; AND TRIGLYCERIDES and to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS and prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors. HN - 2016 (1990) MH - Autism Spectrum Disorder UI - D000067877 MN - F3.625.164.113 MS - Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V) HN - 2016; use CHILD DEVELOPMENT DISORDERS, PERVASIVE 2010-2015 MH - Autoimmune Hypophysitis UI - D000069281 MN - C10.228.140.617.738.100 MN - C19.700.80 MN - C20.111.273 MS - Immune-mediated inflammation of the PITUITARY GLAND often associated with other autoimmune diseases (e.g., HASHIMOTO DISEASE; GRAVES DISEASE; and ADDISON DISEASE). HN - 2016 MH - Banking, Personal UI - D000067012 MN - N3.219.463.30.100 MS - A financial account set up between a financial institution (such as a commercial bank) and a customer (individual, group, or business), whereby the latter may deposit and withdraw money, and where applicable, be paid interest. HN - 2016 FX - Medical Savings Accounts MH - Behavior Observation Techniques UI - D000067289 MN - E5.796.112 MN - F4.669.112 MS - A wide range of formal and informal techniques used to document behavior. HN - 2016 MH - Behavior Rating Scale UI - D000067290 MN - F4.711.271 MS - Instrument designed to assess human or animal behavior, using a standardized format. HN - 2016 MH - Beijing UI - D000068476 MN - Z1.252.474.164.225 MN - Z1.433.114 MS - Capital of CHINA. HN - 2016 MH - Bendamustine Hydrochloride UI - D000069461 MN - D2.241.81.114.625 MN - D2.455.526.728.650.103 MN - D3.438.103.123 MS - A nitrogen mustard compound that functions as an ALKYLATING ANTINEOPLASTIC AGENT and is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA and NON-HODGKIN'S LYMPHOMA. HN - 2016 (1972) MH - Bevacizumab UI - D000068258 MN - D12.776.124.486.485.114.224.60.375 MS - An anti-VEGF recombinant monoclonal antibody consisting of humanized murine antibody. It inhibits VEGF receptors and prevents the proliferation of blood vessels. HN - 2016 (2002) MH - Bimatoprost UI - D000069580 MN - D2.65.141 MN - D10.251.355.255.550.775.500.175.250 MN - D23.469.50.175.725.775.500.175.250 MN - D23.469.700.670.175.250 MS - A cloprostenol-derived amide that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. HN - 2016 (2001) MH - Biobehavioral Sciences UI - D000066949 MN - H1.770.644.108.687 MS - An interdisciplinary scientific approach to the study of complex interactions among biological, social, behavioral, environmental factors, and their effects on health outcomes. HN - 2016 FX - Interdisciplinary Studies MH - Biological Mimicry UI - D000067558 MN - G16.100.57.750 MS - Resemblance in appearance, structure, function, sound, scent or behavior between related or unrelated species, occurring in the same geographic location. HN - 2016 FX - Biomimetics MH - Bioresonance Therapy UI - D066236 MN - E2.190.321.500 MS - A form of holistic medicine in which ELECTROMAGNETIC WAVES are used to diagnose and treat human and animal illness via manipulation of endogenous electromagnetic oscillations corresponding to the patient's current physiological condition. HN - 2016 FX - Magnetic Field Therapy MH - Bipolar and Related Disorders UI - D000068105 MN - F3.84 MS - These disorders are related to both SCHIZOPHRENIA SPECTRUM AND RELATED DISORDERS and DEPRESSIVE DISORDERS in terms of symptomatology, family history, and genetics. (DSM-V) . HN - 2016 MH - Blogs UI - D000069520 MN - V1.175.125 MN - V2.170.250 MN - V2.530.150.250 MS - A website that contains conversational personal reflections, comments and sometimes links to other sites; typically run by an individual or small group. AN - This heading is used as a Publication Type. INDEXER: Do not use HN - 2016 MH - Blood Alcohol Content UI - D000067401 MN - D2.33.375.135 MS - Mass of alcohol per unit of BLOOD volume. HN - 2016 FX - Alcoholism FX - Driving Under the Influence MH - Body Weight Maintenance UI - D000068959 MN - G7.700.320.249.314.120.250 MS - Sustaining BODY WEIGHT after BODY WEIGHT CHANGES have been achieved. HN - 2016 MH - Body, Physical Appearance UI - D000067029 MN - E1.370.600.115.450 MN - G7.100.175 MS - The superficial physical looks, characteristics, or qualities of an individual as distinguished from the underlying unseen nature or attributes. HN - 2016 FX - Body Image MH - Bone-Implant Interface UI - D000069343 MN - A2.835.232.22 MN - A10.165.265.183 MN - E7.695.125 MS - Region of interaction between the bone and PROSTHESES AND IMPLANTS which becomes bonded through cellular and extracellular interactions similar to OSSEOINTEGRATION. HN - 2016 FX - Osseointegration MH - Bortezomib UI - D000069286 MN - D1.29.260.110.500 MN - D1.132.285.500 MN - D2.203.200.500 MN - D3.383.679.450 MS - A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA. HN - 2016 (2000) MH - Brimonidine Tartrate UI - D000068438 MN - D3.438.857.70 MS - A quinoxaline derivative and ADRENERGIC ALHPA-2 RECEPTOR AGONIST that is used to manage INTRAOCULAR PRESSURE associated with OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. HN - 2016 (1978) MH - Brimonidine Tartrate, Timolol Maleate Drug Combination UI - D000068599 MN - D2.33.100.624.915.500 MN - D2.33.755.624.915.500 MN - D2.92.63.624.915.500 MN - D2.886.675.867.768.500 MN - D3.383.129.708.867.768.500 MN - D3.438.857.70.500 MN - D26.310.312 MS - A pharmaceutical preparation of brimonidine tartrate and timolol maleate. The combined ADRENERGIC ALPHA2 RECEPTOR AGONIST and ADRENERGIC BETA-ANTAGONIST activity of these drugs reduce INTRAOCULAR PRESSURE in GLAUCOMA patients. HN - 2016 (2011) MH - Budesonide, Formoterol Fumarate Drug Combination UI - D000069502 MN - D2.33.100.291.425.250 MN - D2.92.63.291.425.250 MN - D4.808.745.745.654.105.500 MN - D26.310.348 MS - A pharmaceutical preparation of budesonide and formoterol fumarate that is used as an ANTI-ASTHMATIC AGENT and for the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. HN - 2016 (2002) MH - Buprenorphine, Naloxone Drug Combination UI - D000069479 MN - D3.132.577.249.150.500 MN - D3.132.577.249.706.275 MN - D3.549.686.150.500 MN - D3.549.686.750.275 MN - D3.605.497.150.500 MN - D3.605.497.750.275 MN - D4.615.723.795.150.500 MN - D4.615.723.795.706.275 MN - D26.310.352 MS - A pharmaceutical preparation that combines buprenorphine, an OPIOID ANALGESIC with naloxone, a NARCOTIC ANTAGONIST to reduce the potential for NARCOTIC DEPENDENCE in the treatment of pain. It may also be used for OPIATE SUBSTITUTION THERAPY. HN - 2016 (2006) MH - Calceolariaceae UI - D000068543 MN - B1.650.940.800.575.100.583.190 MS - A family in the order Lamiales with several species that are used in TRADITIONAL MEDICINE. HN - 2016; for CALCEOLARIA use SCROPHULARIACEAE 2004-2015 BX - Calceolaria MH - Canagliflozin UI - D000068896 MN - D2.886.778.75 MN - D3.383.903.75 MN - D9.408.348.113 MS - A glucoside-derived SODIUM-GLUCOSE TRANSPORTER 2 inhibitor that stimulates urinary excretion of glucose by suppressing renal glucose reabsorption. It is used to manage BLOOD GLUCOSE levels in patients with TYPE 2 DIABETES. HN - 2016 (2014) MH - Canaliculitis UI - D000069282 MN - C11.496.221.500 MS - Inflammation and infection of the lacrimal canaliculus area in the LACRIMAL APPARATUS. HN - 2016 (2010) FX - Corneal Ulcer MH - Capecitabine UI - D000069287 MN - D3.383.742.680.245.500.425 MN - D3.383.742.698.875.404.425 MN - D13.570.230.329.313 MN - D13.570.685.245.500.425 MS - A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER. HN - 2016 (1998) MH - Celecoxib UI - D000068579 MN - D2.65.884.247 MN - D2.886.590.700.247 MN - D3.383.129.539.160 MS - A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN. HN - 2016 (1997) MH - CELF Proteins UI - D000067878 MN - D12.776.157.725.813.250 MN - D12.776.664.962.813.250 MS - A family of RRM proteins which contain two N-terminal RNA RECOGNITION MOTIF (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 amino acids between the second and third RRM domains. They regulate pre-mRNA ALTERNATIVE SPLICING and also function in RNA EDITING and PROTEIN BIOSYNTHESIS. HN - 2016 MH - CELF1 Protein UI - D000067879 MN - D12.776.157.725.813.250.500 MN - D12.776.664.962.813.250.500 MS - A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1. HN - 2016 MH - Cell Plasticity UI - D000066670 MN - G4.299.335.250 MS - The ability of a cell to change its PHENOTYPE in response to changes in the environment. HN - 2016 FX - Neuronal Plasticity MH - Cell Self Renewal UI - D000066673 MN - G4.299.134.220.235 MN - G4.299.233.750.500.375 MN - G5.355.105.415 MN - G7.700.320.249.410.750.500.625 MS - The ability of certain cell types, such as progenitor cells or tumor cells, to go through numerous cycles of CELL DIVISION while still maintaining an undifferentiated or partially differentiated state. HN - 2016 FX - Stem Cells MH - Cellular Reprogramming Techniques UI - D000067470 MN - E5.200.500.380 MN - E5.242.378 MN - E5.393.85 MS - Procedures used for the induction of CELLULAR REPROGRAMMING to change the terminal phenotype of a cell, such as the generation of INDUCED PLURIPOTENT STEM CELLS from differentiated adult cells by the forced expression of specific genes. HN - 2016 FX - Cellular Reprogramming MH - Censorship, Research UI - D000068597 MN - I1.880.604.238 MN - K1.752.566.479.173.200 MN - N5.350.670.250 MS - The act or practice of scrutinizing the practice of scientific research for the purpose of preventing or suppressing the unethical applications as well knowledge derived from it. HN - 2016 FX - Dual Use Research FX - Ethics MH - Certolizumab Pegol UI - D000068582 MN - D5.750.741.125 MN - D12.644.541.500.650.250 MN - D12.776.124.486.485.114.224.60.500 MN - D12.776.124.486.485.680.650.250 MN - D12.776.124.790.651.114.224.60.500 MN - D12.776.124.790.651.680.650.250 MN - D12.776.377.715.548.114.224.200.500 MN - D12.776.377.715.548.680.650.250 MN - D25.720.741.125 MN - J1.637.51.720.741.125 MS - A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. HN - 2016 (2003) MH - Cetuximab UI - D000068818 MN - D12.776.124.486.485.114.224.60.750 MN - D12.776.124.790.651.114.224.60.750 MN - D12.776.377.715.548.114.224.200.750 MS - A chimeric monoclonal antibody that functions as an ANTINEOPLASTIC AGENT through its binding to the EPIDERMAL GROWTH FACTOR RECEPTOR, where it prevents the binding and signaling action of cell growth and survival factors. HN - 2016 (2000) MH - Child Health UI - D000067576 MN - N1.400.225 MS - The concept covering the physical and mental conditions of CHILDREN. HN - 2016; use CHILD WELFARE 1978-2015 FX - Child Health Services FX - Child Welfare MH - Child Protective Services UI - D000068216 MN - I1.409.418.500 MN - N3.540.400.500 MS - Local governmental offices which investigate reports of abuse and neglect of children, and act to assure a safe environment for minors. HN - 2016 (2010); use CHILD WELFARE 2010-2015 FX - Social Work MH - Childhood-Onset Fluency Disorder UI - D000067454 MN - F3.625.374.125 MS - Disturbances in the normal fluency and time patterning of speech that are inappropriate for the individual's age and language skills. (DSM-V) HN - 2016 MH - Children's Health Insurance Program UI - D065326 MN - N3.219.521.576.343.71 MN - N3.349.650.480.500 MS - Federal program, enacted in 1997, for the funding of children's health insurance coverage at the state level for low-income families, affording them effective protection against erosions in employer sponsored coverage. AN - CATALOGER: Use NAF entry HN - 2016 MH - Chronopharmacokinetics UI - D000067573 MN - G7.690.725.249 MS - Absorption, metabolism and elimination of drugs in relation to time of day at which they are administered, and the mechanisms responsible for time-dependent variations. HN - 2016 FX - Drug Chronotherapy MH - Cinacalcet Hydrochloride UI - D000069449 MN - D2.455.426.559.847.638.183 MN - D4.615.638.183 MS - A naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES. HN - 2016 (2003) MH - Clinical Decision-Making UI - D000066491 MN - E1.55 MS - Process of formulating a diagnosis based on medical history and physical or mental examinations, and/or choosing an appropriate intervention. AN - use DECISION MAKING for decision making by the patient HN - 2016 FX - Decision Support Systems, Clinical FX - Decision Support Techniques MH - Clinical Studies as Topic UI - D000068456 MN - E5.318.760.250 MN - N5.715.360.775.88 MN - N6.850.520.450.250 MS - Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. AN - for general design, methodology, economics, etc. of clinical studies; a different heading CLINICAL STUDY is used for reports of a specific clinical study HN - 2016 MH - Clinical Study UI - D000068397 MN - V3.175 MS - A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. AN - This heading is used as a Publication Type for original report of the conduct or results of a specific clinical study. A different heading CLINICAL STUDIES AS TOPIC is used for general design, methodology, economics, etc. of clinical studies. Prefer the specifics: CLINICAL TRIAL or OBSERVATIONAL STUDY. HN - 2016 MH - Clostridiales UI - D000068016 MN - B3.353.625 MS - An order of anaerobic bacteria that are predominantly GRAM POSITIVE within the phylum Firmicutes. It includes the Clostridium and Eubacterium genera. HN - 2016 MH - Cloud Computing UI - D000067917 MN - L1.224.97 MS - Storing and processing data on multiple servers that can be accessed through the Internet. HN - 2016 FX - Technology MH - Coal Industry UI - D000066428 MN - J1.576.655.875.200 MS - Enterprise associated with the mining, processing, marketing and distribution of COAL. HN - 2016 FX - Fossil Fuels MH - Cobicistat UI - D000069547 MN - D2.241.81.251.203 MN - D2.886.675.182 MN - D3.383.129.708.189 MS - A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS. HN - 2016 (2011) MH - Cognitive Aging UI - D000066492 MN - G7.700.320.124.260 MS - Phenomenon that occurs when learning and memory abilities decrease naturally due to age. HN - 2016 FX - Cognition Disorders MH - Cognitive Neuroscience UI - D000066494 MN - F4.96.628.255.500 MN - H1.158.610.30 MS - Field of study concerning MENTAL PROCESSES, LEARNING, and the brain regions associated with them. AN - use for the discipline only (education, history, etc) HN - 2016 MH - Cold Injury UI - D000067390 MN - C26.212 MS - A physical injury caused by exposure of the body to extremely low ambient temperatures that may lead to loss of body parts, or in extreme cases, death. Examples of cold injury are FROSTBITE and CHILBLAINS. HN - 2016 MH - Colesevelam Hydrochloride UI - D000069472 MN - D2.92.50.500 MN - D2.455.326.271.122.100.500 MS - An allylamine derivative that binds BILE ACIDS in the intestine and is used as an ANTICHOLESTEREMIC AGENT in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS. HN - 2016 (1997) MH - Compassion Fatigue UI - D000068376 MN - C23.888.369.500.500 MN - F1.145.126.937.500 MN - F1.145.126.990.469 MN - F2.830.900.333 MS - Stress response that occurs in individuals working in care giving professions. HN - 2016 FX - Burnout, Professional FX - Stress Disorders, Post-Traumatic MH - Computer Heuristics UI - D000067508 MN - L1.224.50.375.95 MS - Trial-and-error methods of problem-solving used when an algorithmic approach is impractical FX - Heuristics MH - Concierge Medicine UI - D000068977 MN - N4.452.758.708.450.500 MS - An arrangement in which a patient pays an annual fee to a physician in exchange for services over and beyond normal insurance-reimbursed services. HN - 2016 MH - Contraceptive Prevalence Surveys UI - D000069216 MN - E5.318.308.980.313 MN - L1.280.960.233 MN - N5.715.360.300.800.313 MN - N6.850.520.308.980.313 MS - Surveys that measure the usage rate of CONTRACEPTIVE DEVICES or CONTRACEPTIVE AGENTS. HN - 2016; use DATA COLLECTION 1987-2015 MH - Cosmeceuticals UI - D000068937 MN - D26.74 MN - D27.720.269.285 MS - COSMETICS that are associated with therapeutic effects. HN - 2016 MH - Crew Resource Management, Healthcare UI - D000067498 MN - N4.590.254 MS - A range of healthcare related training designed to reduce MEDICAL ERRORS and improve PATIENT SAFETY by emphasizing TEAMWORK and human factors (see HUMAN ENGINEERING). HN - 2016 MH - Criminal Behavior UI - D000066479 MN - F1.145.250 MS - Conduct leading to commission of unlawful acts. HN - 2016 FX - Crime FX - Criminal Psychology FX - Criminals MH - Critical Care Outcomes UI - D000066891 MN - N4.761.559.590.399.250 MN - N5.715.360.575.575.200 MS - A measure of the mortality and morbidity rates among patients who receive CRITICAL CARE and INTENSIVE CARE as determined from the date of hospital discharge or release. HN - 2016 MH - Crop Production UI - D000069599 MN - J1.40.227 MS - The science and practice of cultivating PLANTS that have economic value to man. It includes plant breeding, seed production, weeding, use of fertilizers, harvesting, storage, transportation, and marketing. HN - 2016 MH - Crop Protection UI - D000069601 MN - J1.40.237 MS - The science and practice of preventing, minimizing, or eliminating damage to AGRICULTURAL CROPS by pest organisms, weeds, and disease-causing agents. HN - 2016 MH - Culturally Appropriate Technology UI - D000067568 MN - J1.897.52 MS - A SCIENCE or TECHNOLOGY that promotes self-sufficiency and is suitable to the cultural, environmental, economic and social conditions of the geographic area in which it is applied. HN - 2016 FX - Diffusion of Innovation MH - Dabigatran UI - D000069604 MN - D3.383.725.192 MN - D3.438.103.280 MS - A THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation. HN - 2016 (2002) MH - Darbepoetin alfa UI - D000068256 MN - D12.776.395.240.150.500 MS - A recombinant protein which stimulates ERYTHROPOIESIS used to treat ANEMIA. HN - 2016 (2000) MH - Darunavir UI - D000069454 MN - D2.65.884.438 MN - D2.241.81.251.222 MN - D2.886.590.700.400 MN - D3.383.312.303 MS - An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS. HN - 2016 (2004) MH - Dasatinib UI - D000069439 MN - D2.886.675.184 MN - D3.383.129.708.198 MN - D3.383.742.148 MS - A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB. HN - 2016 (2004) MH - Data Accuracy UI - D000068598 MN - E5.318.308.28 MN - E5.318.780.725.250 MN - L1.280.202 MN - N5.715.360.300.202 MN - N5.715.360.780.685.250 MS - A measure of scientific precision, exactness, or correctness of quantitative or qualitative values, relative to the actual or true measurements. HN - 2016; for DATA QUALITY use RESEARCH DESIGN 1995-2015 MH - Data Anonymization UI - D000068240 MN - H1.770.644.205 MN - L1.209.500 MN - N3.706.437.650.124.160 MN - N4.452.910.200.500 MS - Making information permanently non-identifiable that is associated with the identity of specific entities via encryption or other methods. HN - 2016 FX - Personally Identifiable Information MH - Defamation UI - D000067448 MN - I1.198.240.240 MN - I1.880.735.191.51 MS - Public false statements that are illegal and damaging to the reputation of a person, group, business, organization, or institution. HN - 2016 FX - Jurisprudence MH - Denosumab UI - D000069448 MN - D12.776.124.486.485.114.224.60.782 MN - D12.776.124.790.651.114.224.60.782 MN - D12.776.377.715.548.114.224.200.782 MS - A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS. HN - 2016 (2004) MH - Deprescriptions UI - D000069340 MN - E2.319.698.500 MS - Directions written to discontinue use of PRESCRIPTION DRUGS in order to reduce unnecessary and/or excessive medications (see POLYPHARMACY), DRUG SIDE EFFECTS and ADVERSE DRUG REACTION. HN - 2016 FX - Inappropriate Prescribing FX - Potentially Inappropriate Medication List MH - Dermal Fillers UI - D000067548 MN - D27.720.102.461 MS - Materials such as COLLAGEN or HYALURONIC ACID that are injected or deposited into the DERMIS for the purpose of skin augmentation. HN - 2016 FX - Administration, Cutaneous FX - Cosmetic Techniques FX - Injections, Subcutaneous MH - Desvenlafaxine Succinate UI - D000069468 MN - D2.33.415.510.500.303 MN - D2.455.426.392.368.367.318.500 MN - D2.455.426.559.389.657.265 MN - D10.289.510.500.303 MS - A cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. HN - 2016 (1994) MH - Diet, Food, and Nutrition UI - D000066888 MN - G7.203 MS - Concepts involved with nutritional physiology, including categories of substances eaten for sustenance, nutritional phenomena and processes, eating patterns and habits, and measurable nutritional parameters. AN - used for searching; INDEXER: Do not use; CATALOGER: Do not use HN - 2016 MH - Diet, Vegan UI - D000067269 MN - E2.642.249.300.750 MN - G7.203.650.240.300.750 MS - Dietary practice of avoiding animal products in any form. HN - 2016; use DIET, VEGETARIAN 2003-2015 BX - Vegan Diet FX - Vegans MH - Digital Divide UI - D066310 MN - L1.143.230.500 MS - Gap between individuals, households, businesses and geographic areas at different socioeconomic levels with regard to both their opportunities to access electronic information and communication technologies (ICTs). Their use of the Internet for a wide variety of activities, reflects various differences among and within countries. HN - 2016 MH - Dimethyl Fumarate UI - D000069462 MN - D2.241.81.337.302.500 MS - A fumarate derivative that is used as a DERMATOLOGIC AGENT in the treatment of PSORIASIS and SKIN DISEASES. It also may be used as an IMMUNOSUPPRESSIVE AGENT in the treatment of MULTIPLE SCLEROSIS. HN - 2016 (1988) MH - Diplomacy UI - D000067551 MN - F1.829.316.171 MN - F2.463.785.373.520.500 MN - I1.738.305 MS - The art and practice of conducting negotiations between people, nations or other parties such as organizations. HN - 2016 MH - Direct-to-Consumer Advertising UI - D000067088 MN - J1.219.687.274.500 MS - Advertising that directly targets consumers of certain products such as pharmaceuticals. HN - 2016 MH - Direct-To-Consumer Screening and Testing UI - D000067108 MN - E1.370.398 MN - N2.421.726.233.166 MS - Laboratory testing and diagnostic imaging services offered to consumers outside of the patient-physician relationship. HN - 2016 FX - Diagnostic Self Evaluation MH - Distance Counseling UI - D000068237 MN - F2.784.176.350 MN - F4.408.413.437 MN - N2.421.143.303.175 MN - N2.421.461.363.437 MN - N4.452.758.849.550.500 MS - Counseling conducted via electronic or other non-face-to-face interactions. HN - 2016 MH - Dose Hypofractionation UI - D000069473 MN - E2.815.639.200.500 MN - E2.815.639.600 MS - A treatment schedule in which the total dose of radiation is divided into large doses. HN - 2016 FX - Radiation MH - Driving Under the Influence UI - D000066448 MN - F1.145.250.250 MN - F1.145.263.500 MN - I1.880.735.223.250 MN - I3.125.649 MS - Operating a motor vehicle while impaired by alcohol or other drugs including those prescribed by physicians. HN - 2016 MH - Drosophila simulans UI - D000067636 MN - B1.50.500.131.617.289.310.250.750 MS - A species of fruit fly. HN - 2016 MH - Drug Resistant Epilepsy UI - D000069279 MN - C10.228.140.490.125 MS - Epileptic condition in which adequate trials of two tolerated and appropriately chosen and used ANTIEPILEPTIC DRUGS schedules to achieve sustained seizure freedom failed. HN - 2016 MH - Dual Use Research UI - D000068601 MN - H1.770.644.217 MS - Concept relating to technologies and/or information emanating from research that holds the potential for both benevolent and malevolent applications to humanity and the environment. HN - 2016 FX - Censorship, Research MH - Duloxetine Hydrochloride UI - D000068736 MN - D2.886.778.260 MN - D3.383.903.260 MS - A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA. HN - 2016 (1989) MH - Dutasteride UI - D000068538 MN - D4.808.925.100.125 MS - A 5-ALPHA-REDUCTASE INHIBITOR that is reported to inhibit both type-1 and type2 isoforms of the enzyme and is used to treat BENIGN PROSTATIC HYPERPLASIA. HN - 2016 (1998) MH - Dynamic Light Scattering UI - D000067493 MN - E5.196.822.325 MS - An analytical technique for measuring particle size of molecules that are less than a micron in diameter dispersed or dissolved in a liquid. HN - 2016 MH - Ectopic Gene Expression UI - D000066630 MN - G5.355.315.202 MS - The expression of a gene in an abnormal place, or at an abnormal time in an organism. Ectopic Gene Expression is often induced artificially by genetic techniques. HN - 2016 MH - Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination UI - D000068257 MN - D2.705.429.906.125 MN - D3.383.533.375 MN - D3.383.742.680.245.500.600.125 MN - D3.438.759.138.881.125 MN - D26.310.375 MS - Inhibitor or Reverse Transcriptases or of RNA-dIrected DNA polymerase. HN - 2016 (2007) FX - Antiretroviral Therapy, Highly Active MH - ELAV-Like Protein 1 UI - D000067780 MN - D12.776.157.725.813.500.250 MN - D12.776.664.962.813.500.250 MS - An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation. HN - 2016; use ELAV PROTEINS 2012-2015 MH - ELAV-Like Protein 2 UI - D000067777 MN - D12.776.157.725.813.500.500 MN - D12.776.641.520.500 MN - D12.776.664.962.813.500.500 MS - A neural-specific RRM protein that binds to several 3'UTRs, including its own as well as that of PROTO-ONCOGENE PROTEINS C-FOS and ID DNA BINDING PROTEIN INHIBITOR. It binds through the recognition of a GAAA motif in the RNAs. HN - 2016; use ELAV PROTEINS 2012-2015 MH - ELAV-Like Protein 3 UI - D000067778 MN - D12.776.157.725.813.500.750 MN - D12.776.641.520.750 MN - D12.776.664.962.813.500.750 MS - A neural-specific RRM protein which contains three RNP-type RNA recognition motifs (RRMs). Human ELAVL3 is recognized by the anti-Hu serum antibody from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN). It also functions in neurogenesis. HN - 2016; use ELAV PROTEINS 2012-2015 MH - ELAV-Like Protein 4 UI - D000067779 MN - D12.776.157.725.813.500.875 MN - D12.776.641.520.875 MN - D12.776.664.962.813.500.875 MS - An RRM protein which binds AU-rich sequences in the 3' UNTRANSLATED REGIONS of mRNAs for PROTO-ONCOGENE PROTEINS C-FOS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; and GAP-43 PROTEIN. It functions in neuron-specific RNA processing. HN - 2016; use ELAV PROTEINS 2012-2015 MH - Electrocorticography UI - D000069280 MN - E1.370.376.300.294 MN - E1.370.405.245.431 MS - Recording of brain electrical activities in which the electrodes are placed directly on the CEREBRAL CORTEX. HN - 2016 MH - Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination UI - D000069545 MN - D2.241.81.251.203.500 MN - D2.705.429.906.250 MN - D2.886.675.182.500 MN - D3.383.129.708.189.500 MN - D3.383.742.680.245.500.600.250 MN - D3.438.759.138.881.250 MN - D13.570.230.329.525.250 MN - D13.570.685.245.500.600.250 MN - D26.310.391 MS - A pharmaceutical preparation of the ANTI-HIV AGENTS elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate that is used in the treatment of HIV INFECTIONS. HN - 2016 (2012) MH - Embryonic Germ Cells UI - D000066473 MN - A11.497.124 MN - A11.872.700.250.625 MS - PLURIPOTENT STEM CELLS that are derived from early GERM CELLS. HN - 2016 MH - Emotional Adjustment UI - D000066498 MN - F1.58.144 MN - F1.752.543.500.250 MS - Psychological process that occurs when an individual adapts to a significant emotional event or stimulus. HN - 2016; for PSYCHOLOGICAL ADJUSTMENT use ADAPTATION, PSYCHOLOGICAL 2000-2015 FX - Adjustment Disorders FX - Social Adjustment MH - Emtricitabine UI - D000068679 MN - D3.383.742.680.245.500.600 MN - D13.570.230.329.525 MN - D13.570.685.245.500.600 MS - A deoxycytidine analog and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B viruses. It is used to treat HIV INFECTIONS. HN - 2016 (1999) MH - Emtricitabine, Rilpivirine, Tenofovir Drug Combination UI - D000068678 MN - D2.626.809.500 MN - D2.705.429.906.500 MN - D3.383.742.680.245.500.600.500 MN - D3.383.742.755.500 MN - D3.438.759.138.881.500 MN - D26.310.407 MS - A pharmaceutical preparation that contains emtricitabine, rilpivirine and tenofovir disoproxil fumarate. It is used to treat HIV INFECTIONS. HN - 2016 (2012) MH - Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination UI - D000069480 MN - D2.705.429.906.750 MN - D3.383.742.680.245.500.600.750 MN - D3.438.759.138.881.750 MN - D13.570.230.329.525.500 MN - D13.570.685.245.500.600.500 MN - D26.310.423 MS - A pharmaceutical preparation of emtricitabine and tenofovir that is used as an ANTI-HIV AGENT in the treatment and prevention of HIV INFECTIONS. HN - 2016 (2005) MH - Environmental Psychology UI - D000069551 MN - F4.96.628.33 MS - The field that studies interactions between individuals and the built and natural environment. It includes investigating behaviors that inhibit or foster sustainable, climate-healthy, and nature-enhancing choices. AN - use for the discipline (education, history, etc) only HN - 2016 FX - Ecology FX - Environmental Medicine MH - Epoetin Alfa UI - D000068817 MN - D12.644.276.374.410.240.150.500 MN - D12.776.395.240.150.750 MN - D12.776.467.374.410.240.150.500 MN - D23.529.374.410.240.150.750 MS - A recombinant glycosylated form of erythropoietin which stimulates the differentiation and proliferation of erythroid precursors. It is used for the treatment of ANEMIA associated with CHRONIC RENAL FAILURE in dialysis and predialysis patients. HN - 2016 (2011) MH - Erlotinib Hydrochloride UI - D000069347 MN - D3.438.786.375 MS - A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine kinase. It is used in the treatment of NON-SMALL CELL LUNG CANCER. HN - 2016 (1999) MH - Eszopiclone UI - D000069582 MN - D3.383.606.398 MN - D3.383.679.600 MN - D3.383.725.322 MS - A pyridine, pyrazine, and piperazine derivative that is used as a HYPNOTIC AND SEDATIVE in the treatment of INSOMNIA. HN - 2016 (2007) MH - Etanercept UI - D000068800 MN - D12.776.124.486.485.114.619.393.261 MN - D12.776.124.790.651.114.619.393.261 MN - D12.776.377.715.548.114.619.393.261 MN - D12.776.543.750.705.852.760.232 MS - A recombinant version of soluble human TNF receptor that binds specifically to TUMOR NECROSIS FACTOR and inhibits its binding with endogenous TNF receptors. It prevents the inflammatory effect of TNF and is used to treat RHEUMATOID ARTHRITIS; PSORIATIC ARTHRITIS and ANKYLOSING SPONDYLITIS. HN - 2016 (1997) MH - Eugenia UI - D000068856 MN - B1.650.940.800.575.100.773.374 MS - A genus in the family Myrtaceae sometimes known as "stoppers" in FOLK MEDICINE. Many species of the genus SYZYGIUM have synonymous names that begin with the Eugenia genus name. HN - 2016; see SYZYGIUM 2005-2015; see CLOVE 2002-2004 MH - Everolimus UI - D000068338 MN - D2.540.505.760.500 MS - A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT. HN - 2016 (1997) MH - Evidence-Based Facility Design UI - D000067013 MN - N2.278.200.252 MS - An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers. HN - 2016 MH - Exoskeleton Device UI - D000067190 MN - E7.341 MS - Device designed to wear externally to support muscular skeletal system in various movements such as RANGE OF MOTIONS; WEIGHT-BEARING; GAIT; and LOCOMOTION. HN - 2016 FX - Robotics MH - Exposure to Violence UI - D000069581 MN - I1.880.735.900.869 MS - Experience of and exposure to VIOLENCE. HN - 2016 MH - Extracellular Vesicles UI - D000067128 MN - A11.284.295.588 MS - Membrane limited structures derived from cell membranes and cytoplasmic material, and released into EXTRACELLULAR SPACE. They circulate through the EXTRACELLULAR FLUID and through the peripheral blood in the MICROVASCULATURE where cells, much larger, cannot, thereby affecting a variety of intercellular communication processes. HN - 2016 MH - Ezetimibe UI - D000069438 MN - D3.383.82.301.550 MS - An azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS. HN - 2016 (1998) MH - Ezetimibe, Simvastatin Drug Combination UI - D000069499 MN - D2.455.426.559.847.638.400.900.500 MN - D3.383.82.301.550.500 MN - D4.615.638.400.900.500 MN - D26.310.431 MS - A pharmaceutical preparation of ezetimibe and simvastatin that is used in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS. HN - 2016 (2004) MH - Facial Recognition UI - D000066499 MN - F2.463.593.524.500.500 MN - F2.463.593.932.622.500 MS - Ability to identify an individual and interpret their feelings and emotions based on their facial expressions. HN - 2016 MH - Failure to Rescue, Health Care UI - D000067248 MN - E1.789.800.760.500 MN - H1.770.644.145.431.500 MN - N4.761.559.590.200 MN - N4.761.559.590.800.760.500 MN - N5.715.360.575.575.300 MN - N5.715.360.575.575.800.760.500 MS - Inability to prevent a clinical deterioration resulting from a complication of an underlying medical condition or a complication of medical care. It implies that common risk factors for such a complication were not recognized in a timely manner or treated appropriately. HN - 2016 MH - Fallopia UI - D000069263 MN - B1.650.940.800.575.100.825.359 MS - Genus of flowering herbaceous perennial plants and vines in the family Polygonaceae. HN - 2016 MH - Fallopia multiflora UI - D000068676 MN - B1.650.940.800.575.100.825.359.590 MS - A species of Fallopia in the buckwheat family (Polygonaceae). Its roots are used in TRADITIONAL CHINESE MEDICINE. HN - 2016 MH - Farmers UI - D000067565 MN - M1.526.390 MS - Persons who cultivate land or crops, or raise LIVESTOCK. HN - 2016; for AGRICULTURAL WORKERS use AGRICULTURE 1981-2015 MH - Febuxostat UI - D000069465 MN - D2.886.675.274 MN - D3.383.129.708.274 MS - A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT. HN - 2016 (1994) MH - Fecal Microbiota Transplantation UI - D000069467 MN - E2.95.231 MS - Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient. HN - 2016 MH - Filgrastim UI - D000069585 MN - D12.644.276.374.410.240.350.500 MN - D12.776.395.240.200.500 MN - D12.776.467.374.410.240.350.500 MN - D23.529.374.410.240.350.500 MS - A recombinant granulocyte colony-stimulating factor (G-CSF) that is used in the treatment and prevention of NEUTROPENIA, and to prepare blood progenitor cells for collection and use in PERIPHERAL BLOOD STEM CELL TRANSPLANTATION. HN - 2016 (2011) MH - Financial Statements UI - D000067571 MN - N3.219.463.30.140 MS - Formal and structured record of financial activities of a business, person, or other entity. HN - 2016 FX - Financial Management MH - Fingolimod Hydrochloride UI - D000068876 MN - D2.33.100.700.350 MN - D2.33.455.706.431 MN - D2.92.63.700.350 MS - A sphingosine-derivative and IMMUNOSUPPRESSIVE AGENT that blocks the migration and homing of LYMPHOCYTES to the CENTRAL NERVOUS SYSTEM through its action on SPHINGOSINE 1-PHOSPHATE RECEPTORS. It is used in the treatment of MULTIPLE SCLEROSIS. HN - 2016 (1996) MH - Firmicutes UI - D000068536 MN - B3.353 MS - A phylum of predominantly GRAM-POSITIVE BACTERIA that includes the orders Bacillales and Clostridiales. Firmicutes and BACTEROIDETES are the two bacterial phyla that constitute the majority of the human gut MICROBIOTA. HN - 2016 MH - Fluticasone UI - D000068298 MN - D4.808.54.79.129.114 MS - A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS. HN - 2016 (1990) MH - Fluticasone Propionate, Salmeterol Xinafoate Drug Combination UI - D000068297 MN - D2.33.100.291.57.750.500 MN - D2.92.63.291.57.750.500 MN - D2.92.471.683.61.750.500 MN - D4.808.54.79.129.114.500 MN - D26.310.438 MS - A drug combination of fluticasone and salmeterol that is used as an inhaler formulation to manage the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE. HN - 2016 (2001) MH - Formative Feedback UI - D000068156 MN - F2.784.629.529.223 MN - L1.143.283.425.156 MS - Information communicated to the learner that is intended to modify the learner’s thinking or behavior for the purpose of improving learning. HN - 2016 MH - Formoterol Fumarate UI - D000068759 MN - D2.33.100.291.425 MN - D2.92.63.291.425 MS - An ADRENERGIC BETA-2 RECEPTOR AGONIST with a prolonged duration of action. It is used to manage ASTHMA and in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. HN - 2016 (1976) FX - Albuterol FX - Mometasone Furoate MH - Fractures, Multiple UI - D000069076 MN - C26.404.280 MN - C26.640.500 MS - Injuries involving the breaking of either several bones or one bone in two or more places. HN - 2016 MH - Fruit and Vegetable Juices UI - D000067030 MN - G7.203.100.606 MN - J2.200.606 MS - The liquids extracted from plants. AN - coordinate with specific fruit or vegetable HN - 2016 MH - Functional Behavior, Psychology UI - D000068960 MN - F1.145.437 MS - Aberrant or socially inappropriate BEHAVIOR displayed by individuals with cognitive or communication disabilities crucial to the implementation of intervention programs. HN - 2016 MH - Fungal Viruses UI - D000067148 MN - B4.352 MS - Viruses infecting species of FUNGI. AN - coordinate with specific fungus/ virol HN - 2016 MH - Fused Kidney UI - D000069337 MN - C12.706.445 MN - C13.351.875.420 MN - C16.131.939.445 MS - Congenital fusion of two kidneys. HN - 2016 MH - Games, Recreational UI - D000068957 MN - I3.450.642.693.465 MS - Activity typically involving several individuals for the purpose of leisure, amusement, entertainment or pleasure. FX - Video Games MH - Gastrointestinal Microbiome UI - D000069196 MN - G6.755.375 MN - G16.500.275.157.49.100.500.375 MN - N6.230.124.49.100.500.250 MS - All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT. HN - 2016 MH - Gender Dysphoria UI - D000068116 MN - F3.835.550 MS - A marked difference between the individual’s expressed/experienced gender and the gender others would assign him or her, and it must continue for at least six months. (from DSM-5) HN - 2016 MH - Genetic Background UI - D000068617 MN - G5.346 MS - The entire genetic composition of a strain or individual that interacts with a gene of interest. HN - 2016 FX - Heredity MH - Ghee UI - D000067048 MN - D10.212.302.199.500 MN - G7.203.300.350.100.500 MN - G7.203.300.375.200.500 MN - J2.500.350.100.500 MN - J2.500.375.200.500 MS - The clarified portion of milk, cream, or butter obtained by the removal of the nonfat constituents. (from Dictionary of Food Ingredients, 4th ed., 2001) HN - 2016; use DIETARY FATS 1982-2015 MH - Giraffes UI - D000068276 MN - B1.50.150.900.649.77.380.443 MS - Four-legged hoofed mammals with extremely long necks and legs belonging to the family Giraffidae. HN - 2016 MH - Glatiramer Acetate UI - D000068717 MN - D12.644.219 MS - A random polymer of L-ALANINE, L-GLUTAMIC ACID, L-LYSINE, and L-TYROSINE that structurally resembles MYELIN BASIC PROTEIN. It is used in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS. HN - 2016 (1994) MH - Glucagon-Like Peptide Receptors UI - D000067756 MN - D12.776.543.750.100.21 MN - D12.776.543.750.750.360.100 MS - G-PROTEIN COUPLED CELL SURFACE RECEPTORS that bind GLUCAGON-LIKE PEPTIDES and are expressed by cells in pancreatic, intestinal, and neural tissues. These receptors regulate cellular responses to BLOOD GLUCOSE, INSULIN, and INFLAMMATION signals. HN - 2016 MH - Glucagon-Like Peptide-1 Receptor UI - D000067757 MN - D12.776.543.750.100.21.500 MN - D12.776.543.750.750.360.100.500 MS - A receptor for GLUCAGON-LIKE PEPTIDE 1 (GLP-1) expressed primarily on the surface of beta and ductal exocrine cells of the pancreas, as well as cells of other tissues. GLP-1 acts through GLP-1R to potentiate signaling in pancreatic cells in response to glucose-stimulated insulin secretion (GSIS). HN - 2016 MH - Glucagon-Like Peptide-2 Receptor UI - D000067758 MN - D12.776.543.750.100.21.600 MN - D12.776.543.750.750.360.100.600 MS - A receptor for GLUCAGON-LIKE PEPTIDE 2 (GLP-2) that is expressed on the surface of intestinal cells as well as neural cells. GLP-2 and other peptides act through GLP-2R to regulate cellular responses to BLOOD GLUCOSE, INFLAMMATION, and FOOD INTAKE. HN - 2016 MH - Glycemic Load UI - D000067940 MN - G7.203.650.660.750 MN - J1.576.423.850.730.750.750 MN - N6.850.601.750.750 MS - A quantitative value of a measured amount of a specific food that is equal to the GLYCEMIC INDEX of that food multiplied by the carbohydrate content of that food. AN - GLYCEMIC INDEX is also available MH - Grandparents UI - D000066502 MN - F1.829.263.403 MN - I1.880.853.150.452 MN - M1.264 MS - Member of a family who has children and grandchildren. HN - 2016 FX - Family MH - Graphic Novels UI - D000068036 MN - V2.503 MN - V2.700.375 MS - Book-length narratives told using a combination of words and sequential art, often presented in comic book style. from (Fletcher-Spear et al., ALA Review, Winter 2005) AN - This heading is used as a Publication Type. INDEXER: Do not use HN - 2016; use CARTOONS 2014-2015 MH - Health Equity UI - D000069576 MN - N4.590.374.350.500 MN - N5.300.430.383 MS - Opportunity to attain full health potential and no one is disadvantaged from achieving this potential because of their social position or other socially determined circumstance. HN - 2016 MH - Health Smart Cards UI - D000069098 MN - E5.318.308.940.968.625.750 MN - L1.280.900.968.775.500 MN - L1.313.500.750.300.695.300 MN - N4.452.653.250 MN - N4.452.859.564.650.250 MN - N5.715.360.300.715.500.530.500 MN - N6.850.520.308.940.968.625.500 MS - Hand-sized cards with built-in computer chips used for accessing, storing, and protecting patients' medical information. HN - 2016 MH - Healthcare Failure Mode and Effect Analysis UI - D000067495 MN - E5.318.740.600.800.715.500 MN - N4.452.871.715.400 MN - N5.715.360.750.625.700.690.400 MN - N6.850.505.715.500 MN - N6.850.520.830.600.800.715.500 MS - Prospective risk assessment tool aimed at identifying potential risks and their impact in healthcare settings. HN - 2016 MH - Help-Seeking Behavior UI - D000066505 MN - F1.145.813.217 MS - Form of social behavior in which assistance is sought from others. HN - 2016 MH - Heptavalent Pneumococcal Conjugate Vaccine UI - D000069443 MN - D20.215.894.135.750.600.500 MS - A pneumococcal vaccine which 7 pneumococcal serotypes (6B, 14, 19F, 23F, 18C, 4, 9V), each conjugated individually to the outer membrane protein complex of NEISSERIA MENINGITIDIS. HN - 2016 (1996) MH - Heuristics UI - D000066506 MN - F2.463.425.725.500 MN - F2.463.785.810.500 MS - Experience-based techniques for problem-solving, learning, and discovery that find a solution which is not guaranteed to be optimal, but sufficient for a given set of goals. HN - 2016 FX - Artificial Intelligence FX - Computer Heuristics MH - Hoarding Disorder UI - D000067836 MN - F3.80.600.250 MS - Persistent difficulty discarding or parting with possessions due to a perceived need to save the items and distress associated with discarding them. (from DSM-V) HN - 2016 MH - Hoodia UI - D000068798 MN - B1.650.940.800.575.100.81.389 MS - A genus in the dogbane family (Apocynaceae) used in TRADITIONAL MEDICINE for appetite-suppressant properties. HN - 2016 MH - Human Embryonic Stem Cells UI - D000066449 MN - A11.872.700.250.750 MS - A type of PLURIPOTENT STEM CELLS derived from early stage human embryos, up to and including the BLASTOCYST stage. HN - 2016 MH - Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 UI - D000068857 MN - D20.215.894.899.498.500 MS - A vaccine containing L1 capsid proteins from four types of HPV (ALPHAPAPILLOMAVIRUS), types 6, 11, 16 and 18 that is used to prevent infections from HUMAN PAPILLOMAVIRUSES of these subtypes. HN - 2016 (2006) MH - Humidifiers UI - D000068998 MN - E7.451 MN - J1.494.650 MS - Machines that add moisture to the air. HN - 2016 FX - Respiration, Artificial MH - Hydraulic Fracking UI - D000067071 MN - J1.576.655.875.750.500 MS - A drilling technology in which NATURAL GAS is extracted from large deposits of impermeable rock formations known as shale, deep within the earth’s crust. This drilling technique involves injecting large volumes of high-pressure fracturing fluid (a mixture of water, sand, and chemicals) several thousand feet underground, thereby creating cracks or fissures in the shale formation, and releasing trapped gas. HN - 2016 MH - Hyssopus Plant UI - D000068819 MN - B1.650.940.800.575.100.583.520.330 MS - A genus in the mint family (Lamiaceae). Members contain thujone and PHENOL. Distinguished from AGASTACHE (giant hyssop) and BACOPA (water hyssop). Also distinguished from the genus of WASPS with the same genus name Hyssopus. HN - 2016; for HYSSOP use LAMIACEAE 2003-2015 MH - Imatinib Mesylate UI - D000068877 MN - D2.65.277.456 MN - D2.241.223.100.100.435 MN - D2.455.426.559.389.127.85.465 MN - D3.383.606.405 MN - D3.383.742.349 MS - A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors. HN - 2016 (1996) MH - Immunosenescence UI - D000068884 MN - G7.700.320.124.390 MN - G12.460.500 MS - The decline in the function of the IMMUNE SYSTEM during aging. HN - 2016 MH - Incisional Hernia UI - D000069290 MN - C23.300.707.945 MN - C23.550.767.500 MS - Protrusion of tissue at or near the site of an incision from a previous surgery. HN - 2016 MH - Industrial Development UI - D000067896 MN - I1.261.262.500 MN - J1.576.519 MS - Activity concerned with the planning and building of industries through manufacturing, provision of specialized services, and COMMERCE. HN - 2016; for INDUSTRIALIZATION use INDUSTRY 2000-2015 BX - Industrialization MH - Infant Health UI - D000068104 MN - N1.400.388 MS - The concept covering the physical and mental conditions of INFANTS. HN - 2016; use INFANT WELFARE 1994-2015 FX - Infant Welfare MH - Infectious Encephalitis UI - D000069544 MN - C10.228.140.430.520 MN - C10.228.228.399 MS - Brain inflammation caused by an infectious agent.. AN - coordinate IM with specific organism /infection term (IM); note ENCEPHALITIS, VIRAL is available HN - 2016; use ENCEPHALITIS 1964-2015 MH - Infliximab UI - D000069285 MN - D12.776.124.486.485.114.224.608 MN - D12.776.124.790.651.114.224.537 MN - D12.776.377.715.548.114.224.642 MS - A chimeric monoclonal antibody to TNF ALPHA that is used in the treatment of RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; PSORIATIC ARTHRITIS and CROHN'S DISEASE. HN - 2016 (1997) MH - Injection, Intratympanic UI - D000069555 MN - E2.319.267.530.655 MS - The administration of liquid substances into the TYMPANIC CAVITY with a hypodermic syringe. HN - 2016 MH - Insulin Detemir UI - D000069057 MN - D6.472.699.587.200.300.50 MN - D12.644.548.586.200.300.50 MS - A recombinant long-acting insulin and HYPOGLYCEMIC AGENT in which a MYRISTIC ACID is conjugated to a LYSINE at position B29. It is used to manage BLOOD GLUCOSE levels in patients with DIABETES MELLITUS. HN - 2016 (1997) MH - Insulin Glargine UI - D000069036 MN - D6.472.699.587.200.300.100 MN - D12.644.548.586.200.300.100 MS - A recombinant LONG ACTING INSULIN and HYPOGLYCEMIC AGENT that is used to manage BLOOD GLUCOSE in patients with DIABETES MELLITUS. HN - 2016 (1997) MH - Interferon beta-1a UI - D000068556 MN - D12.644.276.374.440.890.275.500 MN - D12.776.467.374.440.890.275.500 MN - D23.529.374.440.890.275.500 MS - An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an ANTI-VIRAL AGENT and IMMUNOMODULATOR and is used to manage the symptoms of RELAPSING-REMITTING MULTIPLE SCLEROSIS. HN - 2016 (1994) MH - Interferon beta-1b UI - D000068576 MN - D12.644.276.374.440.890.275.750 MN - D12.776.467.374.440.890.275.750 MN - D23.529.374.440.890.275.750 MS - A non-glycosylated form of interferon beta-1 that has a serine at position 17. It is used in the treatment of both RELAPSING-REMITTING MULTIPLE SCLEROSIS and CHRONIC PROGRESSIVE MULTIPLE SCLEROSIS. HN - 2016 (1985) MH - Interleukin-33 UI - D000067596 MN - D12.644.276.87.597 MN - D12.644.276.374.465.850 MN - D12.776.467.87.813 MN - D12.776.467.374.465.850 MN - D23.529.87.780 MN - D23.529.374.465.850 MS - A member of the INTERLEUKIN-1 protein family involved in the maturation of TH2 CELLS and the activation of MAST CELLS; BASOPHILS; EOSINOPHILS and NK CELLS. It is also produced by ENDOTHELIAL CELLS; EPITHELIAL CELLS and FIBROBLASTS; where it can function as an alarmin to modulate immune and inflammatory responses to tissue damage. HN - 2016 (2005) MH - Internal Ribosome Entry Sites UI - D000067556 MN - D13.444.735.790.878.942.250 MN - G2.111.570.80.689.687.93 MN - G5.360.80.689.687.93 MS - Sequences within MESSENGER RNA that enable PROTEIN TRANSLATION INITIATION independent of 5' CAPPED RNA. HN - 2016 MH - International Law UI - D000069516 MN - I1.880.604.583.466 MN - N3.706.535.533 MS - The body of law that governs the legal relations between or among sovereign states or nations. HN - 2016 FX - Internationality MH - Intimate Partner Violence UI - D000066511 MN - I1.198.240.856.575 MN - I1.880.735.900.688 MS - A pattern of assaultive and coercive behavior by an individual against their partner or spouse that may include physical injury, psychological abuse, sexual assault, progressive isolation, stalking, deprivation, intimidation, and reproductive coercion. HN - 2016 FX - Sex Offenses MH - Intravital Microscopy UI - D000069416 MN - E1.370.350.515.277 MN - E5.595.185 MS - Microscopic observation of live tissue in situ to study the behavior of individual cells with respect to their in vivo interactions, adhesion, motility, and location. HN - 2016 MH - Iridescence UI - D000068897 MN - G1.590.310 MS - The changing of the color of an object due to variations in the angle of illumination or observation. HN - 2016; for OPALESCENCE (NM) use CARBAMIDE PEROXIDE (NM) 1969-2015 MH - Isolated Heart Preparation UI - D000067268 MN - E5.519 MN - E5.598.750 MS - Method of isolation and maintenance of a working heart for various cardiac measurements. The model allows for the separation of cardiac and systemic variables in the denervated heart. HN - 2016 FX - Myocardial Reperfusion Injury MH - Isophane Insulin, Human UI - D000068880 MN - D6.472.699.587.200.300.200.500 MN - D6.472.699.587.200.500.625.500.500 MN - D12.644.548.586.200.300.200.500 MN - D12.644.548.586.200.500.625.500.500 MS - Human isophane insulin that is used to manage BLOOD GLUCOSE levels in patients with DIABETES. HN - 2016 (2011) MH - Kombucha Tea UI - D000068858 MN - D20.215.784.844.500 MN - G7.203.100.831.500 MN - J2.200.831.500 MS - A beverage made by FERMENTATION of black tea and/or green tea. HN - 2016 MH - Lamiales UI - D000068378 MN - B1.650.940.800.575.100.583 MS - An order of the Lamiidae clade. Lamiales is one of the largest orders of flowering plants and includes pot-herbs in the mint family (MINT; SAGE; OREGANO; BASIL); SESAME, foxgloves; SNAPDRAGONS; and the olive family. HN - 2016; for PROBOSCIDEA PLANT use PEDALIACEAE 2003-2015 BX - Proboscidea Plant MH - Late Onset Disorders UI - D000067562 MN - C23.550.291.883 MS - Pathological conditions (Disorder, SYNDROME, or DISEASE) whose SIGNS AND SYMPTOMS manifest late in the life of an individual. HN - 2016; use AGE OF ONSET 1997-2015 MH - Legal Services UI - D000067408 MN - I1.880.604.583.482 MS - Services provided by ATTORNEYS and paralegal staff. HN - 2016 MH - Legendary Creatures UI - D000068636 MN - I1.76.201.450.515.500 MS - An unverified animal or humanoid, sometimes supernatural, often believed to be real and described in MYTHOLOGY, FOLKLORE, or legends. Some legendary creatures, such as the unicorn, were documented in scholarly antiquarian accounts of natural history. HN - 2016 MH - Libraries, Special UI - D066290 MN - L1.346.596.831 MS - Collections covering specialized subjects, containing materials in a special format, or serving a specialized clientele. HN - 2015 MH - Linagliptin UI - D000069476 MN - D3.438.759.562 MN - D3.438.786.563 MS - A purine and quinazoline derivative that functions as an INCRETIN and DIPEPTIDYL-PEPTIDASE IV INHIBTOR. It is used as a HYPOGLYCEMIC AGENT in the treatment of TYPE II DIABETES MELLITUS. HN - 2016 (2011) FX - Sitagliptin Phosphate MH - Linezolid UI - D000069349 MN - D2.65.64.463 MN - D2.241.81.18.110.525 MN - D3.383.129.462.600.550 MS - An oxazolidinone and acetamide derived ANTI-BACTERIAL AGENT and PROTEIN SYNTHESIS INHIBITOR that is used in the treatment of GRAM-POSITIVE BACTERIAL INFECTIONS of the skin and respiratory tract. HN - 2016 (1996) MH - Liraglutide UI - D000069450 MN - D6.472.317.469.500.500.500 MS - An analog of GLUCAGON-LIKE PEPTIDE 1 and agonist of the GLUCAGON-LIKE PEPTIDE 1 RECEPTOR that is used as a HYPOGLYCEMIC AGENT and supplemental therapy in the treatment of DIABETES MELLITUS by patients who do not respond to METFORMIN. HN - 2016 (2001) MH - Lisdexamfetamine Dimesylate UI - D000069478 MN - D2.92.471.683.152.110.200.500 MS - A dextroamphetamine drug precursor that also functions as a CENTRAL NERVOUS SYSTEM STIMULANT and DOPAMINE UPTAKE INHIBITOR and is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. HN - 2016 (2006) MH - Literacy UI - D000067010 MN - F1.145.209.429 MN - L1.143.563 MN - N1.824.196.500 MS - Ability to read and write. HN - 2016; for ILLITERACY use EDUCATIONAL STATUS BX - Illiteracy FX - Handwriting FX - Health Literacy FX - Reading FX - Writing MH - Long Term Adverse Effects UI - D000069451 MN - C23.550.543 MS - Persistent detrimental effects from treatment for a condition. Included are effects from surgery such as POSTOPERATIVE COMPLICATIONS, and from DRUG THERAPY, such as CHEMICALLY INDUCED DISORDERS, or other THERAPEUTICS. Failure to attain a desired outcome from treatment for the condition is not considered an adverse effect. HN - 2016 MH - Loteprednol Etabonate UI - D000069559 MN - D4.808.54.79.129.284 MS - An androstadiene derivative corticosteroid that is used as an ANTI-ALLERGIC AGENT for the treatment of inflammatory and allergic eye conditions. HN - 2016 (1990) MH - Lubiprostone UI - D000068238 MN - D10.251.355.325.50.500 MS - Member of a bicyclic fatty acid class of compounds derived from PROSTAGLANDIN E1 involved in chloride channel gating. HN - 2016 (2005) MH - Lurasidone Hydrochloride UI - D000069056 MN - D2.886.675.414 MN - D3.383.129.708.414 MN - D3.438.513.437 MS - A thiazole derivative and atypical ANTIPSYCHOTIC AGENT that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST; SEROTONIN 5-HT2 RECEPTOR ANTAGONIST, serotonin 5-HT7 receptor antagonist, and antagonist of the adrenergic α2A and α2C receptors, as well as a partial SEROTONIN 5-HT1A RECEPTOR AGONIST. It is used in the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER. HN - 2016 (2008) MH - Machine Learning UI - D000069550 MN - G17.35.250.500 MN - L1.224.50.375.530 MS - A type of ARTIFICIAL INTELLIGENCE that enable COMPUTERS to independently initiate and execute LEARNING when exposed to new data. HN - 2016; use ARTIFICIAL INTELLIGENCE 1997-2015 MH - Mammary Analogue Secretory Carcinoma UI - D000069295 MN - C4.557.470.200.588 MS - A malignant neoplasm of epithelial cells of the SALIVARY GLANDS, with microcystic architecture, low-grade nuclei, and granular vacuolated cytoplasm. HN - 2016 MH - Maternal Health UI - D000068097 MN - N1.400.900.500 MS - The health of women during PREGNANCY; childbirth and the POSTPARTUM PERIOD. HN - 2016 (1974); use MATERNAL WELFARE 1974-2015 FX - Maternal Health Services FX - Maternal Welfare MH - Maternal-Child Health Services UI - D000068101 MN - N2.421.143.130.660 MN - N2.421.143.620.275 MS - Programs organized for the purpose of providing medical and social services for mothers and children. HN - 2016 (1978); use MATERNAL-CHILD HEALTH CENTERS 1978-2015 MH - Medical Overuse UI - D000069342 MN - N2.421.380.450 MN - N5.300.150.395.450 MS - Excessive or unnecessary utilization of health services by patients or physicians. HN - 2016; for HEALTH SERVICES OVERUTILIZATION use HEALTH SERVICES MISUSE 1978-2015 BX - Overutilization of Health Services FX - Diagnostic Errors FX - Drug Overdose FX - Inappropriate Prescribing FX - Polypharmacy MH - Medical-Surgical Nursing UI - D000069469 MN - H2.478.676.403 MN - N2.421.533.475 MS - The area of nursing concerned with the needs and care of adult medical and surgical patients. HN - 2016 FX - Operating Room Nursing MH - Memory Consolidation UI - D000069077 MN - F2.463.425.540.305.500 MS - Neurological process involving the conversion of learned information into long-term memory. HN - 2016 FX - Learning MH - Metacognition UI - D000067489 MN - F2.463.188.756 MS - Awareness and understanding of one's own thought processes. HN - 2016 FX - Self-Assessment MH - Millets UI - D000066928 MN - B1.650.940.800.575.100.822.587 MS - An agronomic group especially of small-seeded grasses, mainly grown for human and animal consumption. AN - general or unspecified; note several specific millet terms are available HN - 2016 MH - Miners UI - D000067572 MN - M1.526.693 MS - Persons who work in a mine to extract ore or MINERALS from the earth. HN - 2016 MH - Mitochondrial Replacement Therapy UI - D000069321 MN - E2.875.800.750.350 MN - E5.200.500.380.250 MN - E5.393.85.250 MN - E5.820.800.750.350 MS - In vitro fertilization technique that uses mitochondrial DNA from a healthy donor in order to prevent the transmission of MITOCHONDRIAL DISEASE. HN - 2016 MH - Mitochondrial Ribosomes UI - D000069396 MN - A11.284.430.214.190.875.564.755 MN - A11.284.430.214.190.875.811.370 MS - Multicomponent ribonucleoprotein structures contained in MITOCHONDRIA that specialize in the PROTEIN BIOSYNTHESIS of a small number of proteins involved in energy production for the cell. HN - 2016 MH - Mometasone Furoate UI - D000068656 MN - D4.808.745.432.719.526 MS - A pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders. HN - 2016 (1987) FX - Formoterol Fumarate MH - Mometasone Furoate, Formoterol Fumarate Drug Combination UI - D000068758 MN - D2.33.100.291.425.500 MN - D2.92.63.291.425.500 MN - D4.808.745.432.719.526.500 MN - D26.310.469 MS - A pharmaceutical preparation of mometasone furoate and formoterol fumarate that is used as an inhaled dosage form for the treatment of ASTHMA. HN - 2016 (2011) MH - Morcellation UI - D000069577 MN - E4.502.648 MS - Use of a non-cautery–dependent mechanical device that simultaneously cuts and aspirates polyp and/or myoma tissue. HN - 2016 MH - Motor Disorders UI - D000068079 MN - F3.608 MS - Motor skills deficits that significantly and persistently interfere with ACTIVITIES OF DAILY LIVING appropriate to chronological age. (from DSM-V) HN - 2016; use MOTOR SKILLS DISORDERS 1998-2015 MH - Mouse Embryonic Stem Cells UI - D000066450 MN - A11.872.700.250.875 MS - PLURIPOTENT STEM CELLS derived from the BLASTOCYST INNER CELL MASS of day 3.5 mouse embryos. HN - 2016 MH - Mutation Accumulation UI - D000067552 MN - G5.365.590.594 MS - Concept which describes the incremental effects of MUTATION in living organisms. HN - 2016 FX - Aging FX - Mutagenesis MH - Natalizumab UI - D000069442 MN - D12.776.124.486.485.114.224.60.813 MN - D12.776.124.790.651.114.224.60.813 MN - D12.776.377.715.548.114.224.200.813 MS - A humanized monoclonal immunoglobulin G4 antibody to human INTEGRIN ALPHA4 that binds to the alpha4 subunit of INTEGRIN ALPHA4BETA1 and integrin alpha4beta7. It is used as an IMMUNOLOGIC FACTOR in the treatment of RELAPSING-REMITTING MULTIPLE SCLEROSIS and CROHN'S DISEASE. HN - 2016 (2002) FX - Integrin alpha4 MH - Natural Resources UI - D000067936 MN - G16.500.275.553 MN - J1.728 MN - N6.230.350 MS - Materials or substances such as land, timber, fresh water, fossil fuels, or mineral deposits that occur in a natural state and have economic value or usefulness to humans. AN - coordinate with specific natural resource if pertinent HN - 2016; use CONSERVATION OF NATURAL RESOURCES 1991-2015; for LAND SUPPLY use AGRICULTURE 1978-2015 FX - Conservation of Natural Resources MH - Near Miss, Healthcare UI - D000067491 MN - E2.319.529.750 MN - N2.421.450.500.750 MN - N2.421.450.550 MN - N4.761.700.594 MN - N5.700.513 MS - Event that presented a risk but did not result in a patient harm. HN - 2016 MH - Nebivolol UI - D000068577 MN - D2.33.100.291.491 MN - D2.92.63.291.503 MN - D3.383.663.283.755 MN - D3.438.150.755 MS - A cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients. HN - 2016 (1987) MH - Nerve Agents UI - D000067397 MN - D27.720.599 MN - D27.720.777.300.500 MS - A class of compounds that adversely affect the transmission of impulses through the NERVOUS SYSTEM. HN - 2016 MH - Neurodevelopmental Disorders UI - D065886 MN - F3.625 MS - These are a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning. (From DSM-V). HN - 2015 (1998) MH - Neurological Rehabilitation UI - D000066530 MN - E2.831.477 MN - H2.403.680.600.750 MN - N2.421.784.511 MS - Physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the NERVOUS SYSTEM. HN - 2016 MH - Neuropathology UI - D000069338 MN - H1.158.610.184 MN - H2.403.600.250 MN - H2.403.650.375 MS - The branch of medicine and biomedical science concerned with diseases of the nervous system. AN - use for the discipline only (education, history, etc.) only HN - 2016 MH - Neuroprotection UI - D000066829 MN - G11.561.600.638 MS - The physiological processes and techniques used by the body to prevent neuronal injury and degeneration in the central nervous system following acute disorders or as a result of chronic neurodegenerative diseases. HN - 2016 MH - Neurosurgeons UI - D000069471 MN - M1.526.485.810.910.750 MN - N2.360.810.910.750 MS - Qualified medical professionals who specialize in surgical treatment of diseases of the BRAIN and other parts of the NERVOUS SYSTEM. HN - 2016 MH - Neurovascular Coupling UI - D000069336 MN - G9.330.190.163.159.500 MS - Mechanism by which changes in neural activity are tightly associated with regional cortical HEMODYNAMICS and metabolism changes. The association is often inferred from NEUROIMAGING signals (e.g., fMRI; or NIR SPECTROSCOPY). HN - 2016 FX - Hemodynamics MH - No-Show Patients UI - D000067455 MN - F1.145.488.500.750 MN - N4.452.758.635.500 MN - N5.300.150.600.600.750 MS - PATIENTS who do not turn up for scheduled healthcare appointments. Do not confuse with PATIENT DROPOUTS. HN - 2016 FX - Patient Dropouts MH - Obesity, Metabolically Benign UI - D000067329 MN - C18.654.726.500.698 MN - C23.888.144.699.500.250 MN - E1.370.600.115.100.160.120.699.500.375 MN - G7.100.100.160.120.699.500.375 MS - A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity. HN - 2016 MH - Oil and Gas Industry UI - D000066388 MN - J1.576.655.875.750 MS - INDUSTRY concerned with the extraction, processing, distribution, marketing and storage of PETROLEUM and NATURAL GAS. HN - 2015 FX - Fossil Fuels FX - Natural Gas FX - Petroleum MH - Olive Oil UI - D000069463 MN - D10.212.302.380.580 MN - D10.212.507.650 MN - D10.627.700.728 MN - G7.203.300.375.400.500 MN - J2.500.375.400.500 MS - Oil extracted from fruit of the OLIVE TREE (genus Olea). HN - 2016 MH - Olmesartan Medoxomil UI - D000068557 MN - D3.383.129.308.674 MN - D3.383.129.617.584 MS - An ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to manage HYPERTENSION. HN - 2016 (1996) MH - Olopatadine Hydrochloride UI - D000069605 MN - D3.494.382.696 MS - An antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS. HN - 2016 (1992) MH - Omalizumab UI - D000069444 MN - D12.776.124.486.485.114.71.500 MN - D12.776.124.486.485.114.224.60.844 MN - D12.776.124.790.651.114.71.500 MN - D12.776.124.790.651.114.224.60.844 MN - D12.776.377.715.548.114.71.500 MN - D12.776.377.715.548.114.224.200.844 MS - An anti-IgE, recombinant, humanized monoclonal antibody which specifically binds to the C epsilon3 domain of IMMUNOGLOBULIN E, the site of high-affinity IgE receptor binding. It inhibits the binding of IgE to MAST CELLS and BASOPHILS to reduce the severity of the allergic response and is used in the management of persistent allergic ASTHMA. HN - 2016 (2001) MH - Ononis UI - D000068757 MN - B1.650.940.800.575.100.401.604 MS - A genus of the pea family (Fabaceae), native from Europe to Central Asia and used in TRADITIONAL MEDICINE. HN - 2016 MH - Open Access Publishing UI - D066295 MN - L1.737.569 MS - Agreement in which author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use. A complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving. (from Bethesda Statement on Open Access Publishing) HN - 2016 MH - Optimism UI - D000067656 MN - F1.100.787 MS - Mental attitude that interprets life events as generally being positive. HN - 2016 MH - Oral and Maxillofacial Surgeons UI - D000066794 MN - M1.526.485.330.483 MN - N2.360.330.483 MS - Dentists who specialize in the surgical treatment of injuries, diseases, and abnormalities of the oral and maxillofacial regions. HN - 2016 MH - Orexin Receptor Antagonists UI - D000068796 MN - D27.505.519.625.663 MN - D27.505.696.577.663 MN - D27.505.954.842.500 MS - Substances that bind to and inhibit the action of OREXIN RECEPTORS. Drugs in this class have been used as SLEEP AIDS. HN - 2016 MH - Orexins UI - D000068797 MN - D12.644.400.360 MN - D12.776.641.650.363 MS - Neuropeptide hormones that play a role in regulating a variety of behavioral and physiological processes in response to motivational stimuli. HN - 2016 FX - Orexin Receptors MH - Origin of Life UI - D000069497 MN - G16.595 MN - I1.76.368.584.542 MS - The process by which life began. HN - 2016; use ORGANELLE BIOGENESIS 1979-2015 MH - Orthodontists UI - D000066792 MN - M1.526.485.330.655 MN - N2.360.330.655 MS - Dentists who specialize in the treatment of misaligned TEETH and MALOCCLUSION. HN - 2016 MH - Paliperidone Palmitate UI - D000068882 MN - D3.383.129.385.650 MN - D3.383.742.592 MS - A benzisoxazole derivative and active metabolite of RISPERIDONE that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST and SEROTONIN 5-HT2 RECEPTOR ANTAGONIST. It is an ANTIPSYCHOTIC AGENT used in the treatment of SCHIZOPHRENIA. HN - 2016 (1993) MH - Palivizumab UI - D000069455 MN - D12.776.124.486.485.114.224.60.860 MN - D12.776.124.790.651.114.224.60.860 MN - D12.776.377.715.548.114.224.200.860 MS - A humanized monoclonal antibody and ANTIVIRAL AGENT that is used to prevent RESPIRATORY SYNCYTIAL VIRUS INFECTIONS in high risk pediatric patients. HN - 2016 (1998) MH - Parasite Encystment UI - D000069289 MN - G7.700.320.500.550.875 MS - Process by which certain parasites such as GIARDIA and ENTAMOEBA convert from the TROPHOZOITE to SCHIZONT when exposed to stress. HN - 2016 FX - Trophozoites MH - Parks, Recreational UI - D000068316 MN - N6.850.860.410.375 MS - An area of land open to the public for enjoyment. HN - 2016 MH - Parmeliaceae UI - D000068837 MN - B1.300.107.685 MN - B1.300.340.458 MS - The largest family of lichen-forming fungi. HN - 2016 MH - Pathogen-Associated Molecular Pattern Molecules UI - D000069452 MN - D23.585 MS - Pathogens' molecules with specific sequence patterns that are recognized by PATTERN RECOGNITION RECEPTORS. They include microbial DNA, double-stranded RNA, surface glycoproteins, lipopolysaccharides, peptidoglycans, and lipoteichoic acid. HN - 2016 MH - Pedestrians UI - D000069636 MN - M1.665 MS - Persons traveling on foot. HN - 2016 MH - Peer Influence UI - D000067074 MN - F1.829.316.483.750 MS - The effect or sway that a PEER GROUP exerts on the beliefs, value systems and behavior of each member of a group. The social expectations for individuals to conform to peer group influence is known as peer pressure. HN - 2016 MH - Pemetrexed UI - D000068437 MN - D3.438.759.758.399.454.650 MN - D12.125.67.625.525 MN - D12.125.119.409.525 MS - A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE. HN - 2016 (1994) MH - Pericardial Fluid UI - D000069236 MN - A7.541.795.500 MN - A10.615.789.470.500 MN - A12.207.270.651 MS - Watery fluid produced in the serous and visceral pericardium surrounding the surface of the HEART. HN - 2016 MH - Personal Protective Equipment UI - D000067393 MN - E7.662 MS - Specialized clothing or equipment worn for protection against health hazards. Personal Protective Equipment (PPE) may include MASKS, RESPIRATORY PROTECTIVE DEVICES, HEAD PROTECTIVE DEVICES, EYE PROTECTIVE DEVICES, PROTECTIVE CLOTHING and protective footwear. HN - 2016 MH - Personally Identifiable Information UI - D000068241 MN - I1.880.604.583.80.660 MS - Information that can be used to distinguish or trace an individual’s identity, either alone or when combined with other personal or identifying information that is linked or linkable to a specific individual. HN - 2016 FX - Data Anonymization MH - Pessimism UI - D000067657 MN - F1.100.893 MS - Mental attitude that interprets life events as generally being negative. HN - 2016 MH - Phakopsora pachyrhizi UI - D000067563 MN - B1.300.179.110 MS - Fungal pathogen which causes Soybean Rust disease in Soybeans (Glycine max). HN - 2016 MH - Pharmacological Phenomena UI - D000069437 MN - G7.690.773 MS - Interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. AN - general or unspecified; prefer specifics HN - 2016 (2009); for PHARMACOLOGICAL PROCESSES use PHARMACOLOGICAL PROCESSES 2009-2015; for PHARMACOLOGICAL PHENOMENA use PHARMACOLOGICAL PHENOMENA 2009-2015. BX - Pharmacologic Processes BX - Pharmacological Processes MH - Physical Abuse UI - D000066550 MN - I1.198.240.856.688 MN - I1.880.735.900.744 MS - Violence inflicted on an individual through physical contact. HN - 2016 MH - Plant Breeding UI - D000069600 MN - J1.40.227.500 MS - The purposeful manipulation of plant species with the goal of creating desired genotypes and phenotypes, using techniques such as controlled pollination and or genetic engineering, followed by artificial selection of progeny. HN - 2016 MH - Plantaginaceae UI - D000068377 MN - B1.650.940.800.575.100.583.700 MS - A plant family of order Lamiales. The Plantago genus is best known. Lesser known members include Hippuris, Littorella and Callitriche. HN - 2016; for GLOBULARIA and STEMODIA use SCROPHULARIACEAE 2003-2015 BX - Globularia BX - Stemodia MH - Plantar Plate UI - D000069262 MN - A2.165.308.650 MN - A2.513.514.538 MN - A2.835.583.378.531.500 MN - A2.835.583.378.900.500 MN - A2.835.583.512.538 MN - A10.165.382.350.400 MS - Fibrocartilaginous ligament at the metatarsophalangeal and the interphalangeal joint of the toe. HN - 2016 MH - Plasmablastic Lymphoma UI - D000069293 MN - C4.557.386.480.150.585.500 MN - C15.604.515.569.480.150.585.500 MN - C20.683.515.761.480.150.585.500 MS - Malignant lymphoma composed of large B lymphoid cells which have the immunophenotype of plasma cells and a predilection for the ORAL CAVITY. HN - 2016 MH - Podosomes UI - D000069261 MN - A11.284.180.695 MN - A11.436.275.841 MS - Actin-rich adhesive structures found at the ventral surface of metazoan ENDOTHELIAL CELLS. When found in cultured cancer cells they are referred to as invadopodia. These are matrix-degrading structures composed of an ACTIN CYTOSKELETON core and an INTEGRINS-containing ring complex. HN - 2016 FX - Mechanotransduction, Cellular MH - Point-of-Care Testing UI - D000067716 MN - N4.590.874.500 MS - Allows patient diagnoses in the physician’s office, in other ambulatory setting or at bedside. The results of care are timely, and allow rapid treatment to the patient. (from NIH Fact Sheet Point-of-Care Diagnostic Testing, 2010.) HN - 2016; for BEDSIDE TESTING use POINT-OF-CARE SYSTEMS 1995-2015 BX - Bedside Testing MH - Poly(ADP-ribose) Polymerase Inhibitors UI - D000067856 MN - D27.505.519.389.739 MN - D27.505.954.248.692 MS - Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES. HN - 2016 MH - Population Forecast UI - D000069457 MN - I1.320.500 MN - N1.224.667 MS - Estimates of projected population. HN - 2016; use FORECASTING 1981-2015; for POPULATION GROWTH ESTIMATE use POPULATION GROWTH 1980-2015 FX - Population Growth MH - Potentially Inappropriate Medication List UI - D000067561 MN - N4.761.700.615 MN - N5.700.594 MS - A list, criteria, or screening tool designed to improve PATIENT SAFETY by determining an individual's exposure to potentially inappropriate drugs. They are designed to prevent MEDICATION ERRORS by INAPPROPRIATE PRESCRIBING. Analysis for a list includes factors such as DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; AGE FACTORS; GENDER; and existing medical conditions. HN - 2016 FX - Deprescriptions FX - Inappropriate Prescribing MH - Prasugrel Hydrochloride UI - D000068799 MN - D2.886.778.315 MN - D3.383.606.420 MN - D3.383.903.315 MS - A piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS. HN - 2016 (2000) MH - Pregabalin UI - D000069583 MN - D2.241.81.114.500.350.500 MN - D12.125.190.350.450 MS - A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA. HN - 2016 (1993) MH - Prescription Drug Overuse UI - D000067490 MN - E2.319.754.750 MS - The use of a medication in an amount more than as prescribed. HN - 2016 MH - Presenteeism UI - D000069597 MN - F2.784.692.586 MN - F4.96.628.779.450 MS - Reporting for work despite feeling ill. HN - 2016 MH - Prisoner Dilemma UI - D000068956 MN - E5.385.500 MS - A scenario in decision analysis in which two individuals motivated entirely by self-preservation at the expense of the other, end up in a worse state than if they had cooperated with each other in the decision-making process. HN - 2016; use GAME THEORY 1985-2015 BX - Prisoner's Dilemma MH - Problem Behavior UI - D000066553 MN - F1.145.126.972 MN - F1.145.179.750 MS - Troublesome or disruptive behavioral displays. HN - 2016 FX - Attention Deficit and Disruptive Behavior Disorders MH - Professionalism UI - D000068616 MN - K1.752.566.479.171.566 MN - N5.350.340.581 MS - The level of skill, good judgment, and polite behavior expected from people trained to do their jobs well. HN - 2016 FX - Ethics, Medical FX - Professional Competence MH - Protein Corona UI - D000066970 MN - D12.776.642 MS - A layer of protein coating adsorbed by NANOPARTICLES upon entry into PLASMA or other protein-containing biological fluids, which affects how nanoparticles are internalized by cells and cleared from the body. HN - 2016 MH - Protein Translocation Systems UI - D000069284 MN - D5.500.890 MS - Multiprotein complexes that carry out PROTEIN TRANSPORT across CELL MEMBRANES. HN - 2016 FX - Membrane Transport Proteins MH - Prunus africana UI - D000068218 MN - B1.650.940.800.575.100.842.500.625.250 MS - A plant species in the family ROSACEAE. The bark extract known as pygeum is an ingredient in FOLK REMEDIES. HN - 2016 (2002) BX - African Prune BX - Prune, African MH - Prunus armeniaca UI - D000068219 MN - B1.650.940.800.575.100.842.500.625.375 MS - A plant species in the family ROSACEAE. It is the source of apricot fruit. HN - 2016; use PRUNUS 2002-2015; for APRICOT use PRUNUS 2002-2015 and ROSALES 1998-2001 BX - Apricot MH - Prunus avium UI - D000068220 MN - B1.650.940.800.575.100.842.500.625.400 MS - A plant species in the family ROSACEAE. It is the source of the sweet cherry fruit. HN - 2016; for PRUNUS SEROTINA use PRUNUS 2002-2015 MH - Prunus domestica UI - D000068242 MN - B1.650.940.800.575.100.842.500.625.450 MS - A plant species in the family ROSACEAE. It is a tree that produces fruits called plums. HN - 2016; for PRUNUS CERASIFERA use PRUNUS 2002-2015; for PLUM use PRUNUS 2002-2015 BX - Plum MH - Prunus dulcis UI - D000068181 MN - B1.650.940.800.575.100.842.500.625.500 MS - A plant species in the family ROSACEAE, genus Prunus which produces edible seeds called almonds. HN - 2016; for ALMONDS use PRUNUS 2002-2015 MH - Prunus persica UI - D000068239 MN - B1.650.940.800.575.100.842.500.625.750 MS - A plant species in the family ROSACEAE. It is a tree that produces peach fruit. HN - 2016; use PRUNUS 2002-2015; for PEACH use PRUNUS 2002-2015 BX - Peach MH - Psychiatric Rehabilitation UI - D000067250 MN - H2.403.680.600.875 MN - N2.421.784.578 MS - Specialty field that promotes recovery, community functioning, and increased well-being of individuals diagnosed with mental disorders that impair their ability to live meaningful lives. HN - 2016 MH - Psychiatry in Literature UI - D066291 MN - K1.517.584.500 MS - Written or other literary works whose subject matter is related to mental disorders or psychiatry from the lay or practitioner perspective. . AN - coordinate IM with psychiatric aspect (IM) + specific literature heading (IM) + literary type if pertinent (as POETRY; DRAMA, etc.) (IM) HN - 2016 MH - Psychological Trauma UI - D000067073 MN - F3.950.750.375 MS - Overwhelming emotional damage caused by a distressful event or series of events. HN - 2016 FX - Stress Disorders, Post-Traumatic MH - Psychology, Sports UI - D000067450 MN - F4.96.628.914 MS - Field of research that studies mental factors influencing the attainment of athletic skills and athletic performance. HN - 2016 FX - Sports Medicine MH - Public Service Announcements UI - D066309 MN - V2.736 MS - Works consisting of announcements which promote programs, activities, or services of federal, state, or local governments or those of non-profit organizations and other announcements regarded as serving community interests. AN - This heading is used as a Publication Type. Public Service Announcements as a subject are indexed under the heading Public Service Announcement as Topic; INDEXER: Do not use HN - 2016 MH - Public Service Announcements as Topic UI - D066308 MN - L1.143.805 MS - Announcements for which no charge is made and which promote programs, activities, or services of federal, state, or local governments or those of non-profit organizations and other announcements regarded as serving community interests. AN - do not confuse with the Publication Type PUBLIC SERVICE ANNOUNCEMENTS HN - 2015 MH - Pyroptosis UI - D000069292 MN - G4.299.139.160.530 MS - Type of programmed cell death associated with infection by intracellular pathogens. It is characterized by INFLAMMASOME formation; activation of CASPASE 1; and CYTOKINES mediated inflammation. HN - 2016 FX - Necrosis MH - Quetiapine Fumarate UI - D000069348 MN - D2.886.680.702.500.500 MN - D3.494.276.500 MS - A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER. HN - 2016 (1991) MH - Radiation Exposure UI - D000069079 MN - G1.750.748 MN - N6.850.460.350.850 MS - Phenomenon in which organisms are subjected to radiation. HN - 2016 FX - Environmental Pollutants MH - Raltegravir Potassium UI - D000068898 MN - D3.383.773.812.752 MS - A pyrrolidinone derivative and HIV INTEGRASE INHIBITOR that is used in combination with other ANTI-HIV AGENTS for the treatment of HIV INFECTION. HN - 2016 (2006) MH - Ranibizumab UI - D000069579 MN - D12.776.124.486.485.114.224.60.868 MN - D12.776.124.790.651.114.224.60.868 MN - D12.776.377.715.548.114.224.200.868 MS - A recombinant humanized monoclonal antibody fragment that binds VEGF-A to prevent its binding to VEGFR-1 and VEGFR-2 receptors. This activity reduces vessel permeability and angiogenesis in the treatment of neovascular age-related MACULAR DEGENERATION. HN - 2016 (2005) MH - Ranolazine UI - D000069458 MN - D2.65.199.92.850 MN - D3.383.606.841 MS - An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS. HN - 2016 (1988) MH - RAW 264.7 Cells UI - D000067996 MN - A11.251.210.172.875 MN - A11.733.397.815 MS - A transformed macrophage cell line isolated from ASCITES of mice infected with ABELSON MURINE LEUKEMIA VIRUS. AN - almost always NIM with no subheadings; check ANIMALS and MICE HN - 2016 MH - Re-Irradiation UI - D000069475 MN - E2.815.791 MN - E2.887.500 MS - Treatment in which a repeat course of RADIOTHERAPY is administered. HN - 2016 MH - Red Meat UI - D000069466 MN - G7.203.300.600.813 MN - J2.500.600.813 MS - Meat such as beef, pork, or lamb which contains more MYOGLOBIN than POULTRY or SEAFOOD. HN - 2016 MH - Refugium UI - D000068236 MN - G16.500.275.683 MN - G16.500.819 MS - Area in an environment in which a population of organisms can survive through a period of unfavorable conditions. HN - 2016 MH - Rehabilitation Research UI - D000066768 MN - H1.770.644.145.472 MS - Studies and research concerning the psychological, educational, social, vocational, industrial, and economic aspects of REHABILITATION. HN - 2016 FX - Disabled Persons MH - Return to Sport UI - D000068958 MN - I3.450.642.845.605 MS - Resumption of sporting activity following a hiatus or period of absence due to injury or other reasons. HN - 2016 MH - Rilpivirine UI - D000068696 MN - D2.626.809 MN - D3.383.742.755 MS - A diarylpyrimidine derivative and REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 that is used in the treatment of HIV INFECTIONS. It is also used in combination with other ANTI-HIV AGENTS, since ANTIVIRAL DRUG RESISTANCE emerges rapidly when it is used alone. HN - 2016 (2005) MH - Risedronate Sodium UI - D000068296 MN - D2.705.429.500.830.500 MS - An aminobisphosphonate derivative of etidronic acid and CALCIUM CHANNEL BLOCKER that inhibits BONE RESORPTION and is used for the treatment of OSTEOPOROSIS. HN - 2016 (2014) MH - Rituximab UI - D000069283 MN - D12.776.124.486.485.114.224.75.785 MN - D12.776.124.790.651.114.224.75.785 MN - D12.776.377.715.548.114.224.284.785 MS - A murine-derived monoclonal antibody and ANTINEOPLASTIC AGENT that binds specifically to the CD20 ANTIGEN and is used in the treatment of LEUKEMIA; LYMPHOMA and RHEUMATOID ARTHRITIS. HN - 2016 (1995) MH - Rivaroxaban UI - D000069552 MN - D2.886.778.727 MN - D3.383.533.640.713 MN - D3.383.903.727 MS - A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME. HN - 2016 (2005) MH - Rivastigmine UI - D000068836 MN - D2.241.81.251.583.899 MS - A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE. HN - 2016 (1992) MH - RNA Recognition Motif (RRM) Proteins UI - D000067776 MN - D12.776.157.725.813 MN - D12.776.664.962.813 MS - A family of RNA-BINDING PROTEINS which contain a motif consisting of two ribonucleoprotein (RNP) domains that bind RNA, and other domains that allow for high affinity binding, sequence specificity, and protein interactions. Examples of RRM proteins include HETEROGENEOUS NUCLEAR RIBONUCLEARPROTEINS (hnRNP) and EMBRYONIC LETHAL ABNORMAL-VISION (ELAV) proteins. HN - 2016 MH - RNAi Therapeutics UI - D000067492 MN - E2.95.301.250 MS - A form of disease treatment which involves the silencing of genes that are associated with a disease by the process of RNA INTERFERENCE. HN - 2016 FX - Gene Expression Regulation MH - Romanticism UI - D066288 MN - K1.883 MS - The attitude or intellectual orientation that characterized many works of literature, painting, music, architecture, criticism, and historiography in Western civilization over a period from the late 18th to the mid-19th century. HN - 2016 MH - Rosuvastatin Calcium UI - D000068718 MN - D2.65.884.650 MN - D2.455.526.510.432.500 MN - D2.886.590.700.650 MN - D3.383.742.775 MS - A HYDROXYMETHYLGLUTARYL-COA-REDUCTASE INHIBITOR, or statin, that reduces the plasma concentrations of LDL-CHOLESTEROL; APOLIPOPROTEIN B, and TRIGLYCERIDES while increasing HDL-CHOLESTEROL levels in patients with HYPERCHOLESTEROLEMIA and those at risk for CARDIOVASCULAR DISEASES. HN - 2016 (2001) FX - Simvastatin MH - Round Ligament of Femur UI - D000069593 MN - A2.513.514.800 MN - A2.513.901.500 MN - A2.835.583.411.500 MN - A2.835.583.512.950 MS - Ligament that connects the fovea of the FEMUR HEAD and the ACETABULUM notch in the HIP JOINT. MH - Round Ligament of Liver UI - D000069592 MN - A2.513.901.750 MN - A3.620.575 MS - A cord-like remnant structure formed from the closed left fetal UMBILICAL VEIN. It is located along the lower edge of the falciform ligament. MH - Round Ligaments UI - D000069590 MN - A2.513.901 MS - Cord-like fibrous tissue structure that connects two articular extremities of bones, ligaments and /or cartilages. HN - 2016 BX - Round Ligament MH - S100A12 Protein UI - D000067616 MN - D12.644.276.87.901 MN - D12.776.157.125.750.875 MN - D12.776.467.87.937 MN - D23.529.87.943 MS - A member of the S100 PROTEIN FAMILY that regulates INFLAMMATION and the immune response. It recruits LEUKOCYTES, promotes cytokine and chemokine production, and regulates leukocyte adhesion and migration. S100A12 can also function via binding to ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTORS, to stimulate innate immune cells. HN - 2016 (1994) MH - Saline Waters UI - D000068357 MN - G16.500.275.725 MS - Water from natural sources which contain significant concentrations of dissolved salts such as sodium chloride. HN - 2016 FX - Hypertonic Solutions MH - Salmeterol Xinafoate UI - D000068299 MN - D2.33.100.291.57.750 MN - D2.92.63.291.57.750 MN - D2.92.471.683.61.750 MS - A selective ADRENERGIC BETA-2 RECEPTOR agonist that functions as a BRONCHODILATOR when administered by inhalation. It is used to manage the symptoms of ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE. HN - 2016 (1989) MH - Seed Bank UI - D000068098 MN - N2.278.65.650 MS - A repository of seeds maintained under optimal conditions that ensure long term storage, intended for use as a source of replenishment of seed stock or plant genetic material. HN - 2016 MH - Selective Breeding UI - D000068618 MN - E5.820.150.760 MN - G5.355.90.701 MS - A process in which offspring possessing desired genetic traits are produced. HN - 2016 FX - Eugenics FX - Reproductive Techniques MH - Self Expandable Metallic Stents UI - D000069322 MN - E7.695.750.750 MS - Cylindrical metallic tubes that are inserted to hold open a structure in order to treat vascular, bile duct, esophageal and other tubular organ constrictions. HN - 2016 MH - Self-Control UI - D000068356 MN - F1.145.813.595 MS - An individual's ability to manage and monitor their emotions, behaviors, and desires in the face of external demands in order to function in society. HN - 2016; for SELF REGULATION use SOCIAL CONTROL, INFORMAL 1997-2015 FX - Temperance MH - Serine-Arginine Splicing Factors UI - D000068103 MN - D12.776.157.725.844 MN - D12.776.664.962.844 MS - A family of splicing regulatory factors essential for constitutive and alternative splicing in RNA metabolism. HN - 2016 (1995) MH - Seroconversion UI - D000069078 MN - G12.425.900 MS - The appearance of antibodies against causative agents in the blood of individuals during the course of an infection or following immunization. HN - 2016 FX - Immune System Phenomena MH - Serotonin and Noradrenaline Reuptake Inhibitors UI - D000068760 MN - D27.505.519.562.437.693 MN - D27.505.519.625.600.693 MN - D27.505.696.577.600.693 MS - Drugs that selectively block or suppress the plasma membrane transport of SEROTONIN and NORADRENALINE into axon terminals and are used as ANTIDEPRESSIVE AGENTS. HN - 2016 MH - Sevelamer UI - D000069603 MN - D2.92.782.634 MS - A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease. HN - 2016 (2000) MH - Severe Acute Malnutrition UI - D000067011 MN - C18.654.521.719 MS - Acute form of MALNUTRITION which usually affects children, characterized by a very low weight for height (below -3z scores of the median World Health Organization standards), visible severe wasting, or occurrence of nutritional EDEMA. It can be a direct or indirect cause of fatality in children suffering from DIARRHEA and PNEUMONIA. Do not confuse with starvation, a condition in which the body is not getting enough food, usually for extended periods of time. HN - 2016 MH - Shellfish Hypersensitivity UI - D000067208 MN - C20.543.480.370.763 MS - Allergic reaction to SHELLFISH or shellfish products. HN - 2016 FX - Shellfish Poisoning MH - Sildenafil Citrate UI - D000068677 MN - D2.65.884.675 MN - D2.886.590.700.675 MN - D3.383.606.854 MN - D3.438.759.824 MS - A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION. HN - 2016 (1997) FX - Tadalafil MH - Silent Mutation UI - D000069456 MN - G5.365.590.803 MS - A change to a DNA SEQUENCE that doesn't change the AMINO ACID SEQUENCE of the protein made. HN - 2016 MH - Simeprevir UI - D000069616 MN - D2.886.590.700.700 MN - D3.494.819 MS - Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS. HN - 2016 (2008) MH - Simulation Training UI - D000066908 MN - I2.903.847 MS - A highly customized interactive medium or program that allows individuals to learn and practice real world activities in an accurate, realistic, safe and secure environment. HN - 2016 MH - Sitagliptin Phosphate UI - D000068900 MN - D3.383.129.799.725 MN - D3.383.679.875 MS - A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES. HN - 2016 (2005) FX - Linagliptin MH - Sitagliptin Phosphate, Metformin Hydrochloride Drug Combination UI - D000068899 MN - D2.78.370.141.450.500 MN - D3.383.129.799.725.500 MN - D3.383.679.875.500 MN - D26.310.750 MS - A pharmaceutical preparation of sitagliptin phosphate and metformin hydrochloride that is used in the treatment of TYPE 2 DIABETES. HN - 2016 (2008) MH - Sleep Aids, Pharmaceutical UI - D000068776 MN - D27.505.954.842 MS - Drugs used to induce SLEEP, prevent SLEEPLESSNESS, or treat SLEEP INITIATION AND MAINTENANCE DISORDERS. HN - 2016 MH - Smartphone UI - D000068997 MN - L1.178.847.698.300.250 MN - L1.224.230.260.550.500.500 MS - A cellular phone with advanced computing and connectivity capability built on an operating system. HN - 2016; use CELL PHONES 2015 FX - Computers, Handheld MH - Social Communication Disorder UI - D000067404 MN - F3.625.374.250 MS - Persistent difficulties in the social uses of verbal and nonverbal communications. (DSM-V) HN - 2016 MH - Social Learning UI - D000067570 MN - F2.784.629.529.663 MS - The concept of new knowledge acquisition through observation and interaction with others. HN - 2016 FX - Socialization MH - Social Workers UI - D000068217 MN - M1.526.919 MS - Professionals who work with persons affected by social disadvantages such as POVERTY; mental and physical illness or disability, and social injustice. Their focus is on both the individual and his or her environment, including violations of their civil liberties and human rights. HN - 2016 (1976); use SOCIAL WORK 1976-2015 MH - Sofosbuvir UI - D000069474 MN - D3.383.742.686.850.877.500 MN - D13.695.740.850.877.500 MN - D13.695.827.919.877.500 MS - A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C. HN - 2016 (2010) MH - Solifenacin Succinate UI - D000069464 MN - D3.438.531.820.594 MN - D3.605.687.900 MS - A quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE. HN - 2016 (2001) MH - South Sudan UI - D000068037 MN - Z1.58.290.120.745 MS - A nation located in East-Central Africa; south of Sudan, north of Uganda and Kenya, west of Ethiopia. Independence from SUDAN was attained on 9 July 2011. The capital is Juba. (from CIA. World Factbook, 2014.) HN - 2016 MH - Spatial Regression UI - D000068916 MN - E5.318.740.750.862 MN - E5.318.740.933.375 MN - N5.715.360.750.695.825 MN - N5.715.360.750.746.375 MN - N6.850.520.830.750.862 MN - N6.850.520.830.933.375 MS - Methods used to take into account and incorporate spatial autocorrelation and regional variation into regression analysis models of data that has spatial dependency, and also to provide information on the spatial relationships among the variables. HN - 2016 MH - Specific Learning Disorder UI - D000067559 MN - F3.625.562.700 MS - Diagnosed when there are specific deficits in an individual’s ability to perceive or process information efficiently and accurately. This disorder first manifests during the years of formal schooling and is characterized by persistent and impairing difficulties with learning foundational academic skills in reading, writing, and/or math. The individual’s performance of the affected academic skills is well below average for age, or acceptable performance levels are achieved only with extraordinary effort. Specific learning disorder may occur in individuals identified as intellectually gifted and manifest only when the learning demands or assessment procedures (e.g., timed tests) pose barriers that cannot be overcome by their innate intelligence and compensatory strategies. For all individuals, specific learning disorder can produce lifelong impairments in activities dependent on the skills, including occupational performance. (from DSM-V) HN - 2016 MH - Speech Sound Disorder UI - D066229 MN - F3.625.374.500 MS - Persistent difficulty with speech sound production such that it interferes with verbal communication. HN - 2015 MH - Spirit Possession UI - D000067496 MN - K1.844.619.500 MS - The idea that abnormal behavior or a medical condition is evidence that a person is under the control of a supernatural power or spirit. This belief was most commonly held in religion and medicine of the medieval period and is also held in many tribal cultures today. HN - 2016 FX - Parapsychology FX - Superstitions MH - Superficial Musculoaponeurotic System UI - D000069259 MN - A1.456.505.875 MN - A1.598.500 MS - Layer between the superficial fat compartment and superficial facial muscles in the head and the neck. HN - 2016 FX - Rhytidoplasty MH - Supervised Machine Learning UI - D000069553 MN - G17.35.250.500.500 MN - L1.224.50.375.530.500 MS - A MACHINE LEARNING paradigm used to make predictions about future instances based on a given set of labeled paired input-output training (sample) data. HN - 2016 FX - Unsupervised Machine Learning MH - Surgical Clearance UI - D000068436 MN - E1.370.505 MS - Process of evaluating the health of a patient and determining if they are healthy enough for surgery. HN - 2016 FX - Physical Examination MH - Symptom Flare Up UI - D000067251 MN - C23.550.291.937.500 MS - A transient exacerbation of symptoms of an existing disease or condition. HN - 2016 MH - Tadalafil UI - D000068581 MN - D3.383.725.150.500 MN - D3.438.473.155.500 MN - D3.494.154.672 MS - A carboline derivative and PHOSPHODIESTERASE 5 INHIBITOR that is used primarily to treat ERECTILE DYSFUNCTION; BENIGN PROSTATIC HYPERPLASIA and PRIMARY PULMONARY HYPERTENSION. HN - 2016 (2001) FX - Sildenafil Citrate MH - Teas, Herbal UI - D000069459 MN - D20.215.784.937 MN - G7.203.100.950 MN - J2.200.950 MS - Beverages prepared from an infusion of plant tissues. HN - 2016; use BEVERAGES 1986-2015 BX - Herbal Teas MH - Teas, Medicinal UI - D000069460 MN - G7.203.100.975 MN - J2.200.975 MS - Beverages used in TRADITIONAL MEDICINE that are prepared from the infusion of plant tissue (HERBAL TEA), and/or animal tissue or other organisms such as FUNGI. HN - 2016; use BEVERAGES 1986-2015 MH - Telerehabilitation UI - D000069350 MN - E2.831.891 MN - H2.403.680.600.937 MN - H2.403.840.850 MN - L1.178.847.652.850 MN - N2.421.784.840 MN - N4.590.374.800.850 MS - Delivery of therapeutic rehabilitation at a distance or offsite using telecommunication technologies. HN - 2016 MH - Telocytes UI - D000067170 MN - A11.329.830.750 MS - A type of interstitial cells that have very long and thin CELL SURFACE EXTENSIONS called TELOPODES. HN - 2016; for INTERSTITIAL CELL OF CAJAL-LIKE CELLS use INTERSTITIAL CELLS OF CAJAL 2010-2015 FX - Interstitial Cells of Cajal MH - Telopodes UI - D000067617 MN - A11.284.180.900 MN - A11.329.830.750.500 MS - The very long and thin extensions of telocytes' cell surface, that have alternating thick and thin sections called podoms and podomers. HN - 2016 MH - Tenofovir UI - D000068698 MN - D2.705.429.906 MN - D3.438.759.138.881 MS - An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone. HN - 2016 (2001) MH - Theranostic Nanomedicine UI - D000068936 MN - E1.894 MN - E2.921 MN - H1.603.600.500 MN - H2.403.845 MN - J1.897.520.600.600.500 MS - An integrated nano-scale approach to MEDICINE which involves concurrent diagnosis, drug delivery, therapy, and monitoring of therapeutic response. HN - 2016 MH - Thoracentesis UI - D000069258 MN - E1.370.225.998.329.810 MN - E2.800.550.810 MN - E4.665.600.810 MN - E5.200.998.329.810 MS - Aspiration of fluid or air from the THORACIC CAVITY. It is coupled sometimes with the administration of drugs into the PLEURAL CAVITY. HN - 2016 FX - Pleural Effusion FX - Pneumothorax MH - Time Out, Healthcare UI - D000067494 MN - N4.761.700.635 MN - N5.700.739 MS - A period of time away from normal workflow taken to ensure key procedural details have been reviewed for better PATIENT SAFETY and help prevent MEDICAL ERRORS. HN - 2016 MH - Tiotropium Bromide UI - D000069447 MN - D2.145.74.722.822.887 MN - D3.132.889.601.887 MN - D3.605.869.822.887 MN - D4.75.80.875.99.722.822.887 MS - A scopolamine derivative and CHOLINERGIC ANTAGONIST that functions as a BRONCHODILATOR AGENT. It is used in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. HN - 2016 (1993) MH - Tolterodine Tartrate UI - D000068737 MN - D2.33.100.624.706.750 MN - D2.33.755.624.706.750 MN - D2.92.63.624.706.800 MN - D2.455.426.559.389.115.900 MN - D2.455.426.559.389.657.239.756 MS - An ANTIMUSCARINIC AGENT selective for the MUSCARINIC RECEPTORS of the BLADDER that is used in the treatment of URINARY INCONTINENCE and URINARY URGE INCONTINENCE. HN - 2016 (1996) MH - Toxicological Phenomena UI - D000069436 MN - G7.690.936 MS - The nature and effects of chemical, physical or biological poisons on living organisms. AN - general or unspecified; prefer specifics HN - 2016 MH - Trachelectomy UI - D000069339 MN - E4.950.300.399.690 MS - Surgical removal or resection of the CERVIX UTERI. HN - 2016 MH - Transanal Endoscopic Microsurgery UI - D000067369 MN - E1.370.388.250.630.500.500 MN - E4.210.240.250.680.500.500 MN - E4.494.787 MN - E4.502.250.250.250.680.500.500 MN - E4.502.250.630.500.500 MS - A specialized form of transanal endoscopic surgery for microscopically controlled operations in the RECTUM. HN - 2016 MH - Transanal Endoscopic Surgery UI - D000067368 MN - E1.370.388.250.630.500 MN - E4.210.240.250.680.500 MN - E4.502.250.250.250.680.500 MN - E4.502.250.630.500 MS - Surgical procedures performed through the anus using a PROCTOSCOPE. HN - 2016 MH - Transitional Care UI - D000069341 MN - E2.204.812 MN - E2.760.940 MN - N2.421.192.812 MN - N2.421.585.940 MN - N4.590.233.727.210.812 MS - Health care provided during a transition to a different mode of care (e.g., TRANSITION TO ADULT CARE). HN - 2016 MH - Trastuzumab UI - D000068878 MN - D12.776.124.486.485.114.224.60.875 MN - D12.776.124.790.651.114.224.60.875 MN - D12.776.377.715.548.114.224.200.875 MS - A humanized monoclonal antibody against the ERBB-2 RECEPTOR (HER2). As an ANTINEOPLASTIC AGENT, it is used to treat BREAST CANCER where HER2 is overexpressed. HN - 2016 (1998) MH - Trauma and Stressor Related Disorders UI - D000068099 MN - F3.950 MS - Disorders in which exposure to a traumatic or stressful event is explicitly a diagnostic criterion. HN - 2016 MH - Travoprost UI - D000069557 MN - D10.251.355.255.550.775.500.175.500 MN - D23.469.50.175.725.775.500.175.500 MN - D23.469.700.670.175.500 MS - A cloprostenol derivative that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION. HN - 2016 (2001) MH - Triticale UI - D000066889 MN - B1.650.940.800.575.100.822.906 MS - A CEREAL GRAIN plant resulting from a cross between TRITICUM and SECALE CEREALE. HN - 2016; use EDIBLE GRAIN 1998-2015 MH - Twin-Arginine-Translocation System UI - D000069294 MN - D5.500.890.750 MS - Protein translocase in BACTERIA or CHLOROPLASTS that exports or secretes folded proteins. In GRAM-NEGATIVE BACTERIA, twin-arginine translocase (TAT) is involved in the export of folded proteins to the PERIPLASM. In chloroplasts, TAT is involved in transporting folded proteins across the membranes of THYLAKOIDS. HN - 2016 MH - Tympanocentesis UI - D000069356 MN - E1.370.225.998.329.905 MN - E2.800.550.905 MN - E4.665.600.905 MN - E5.200.998.329.905 MS - Needle aspiration of fluid from the MIDDLE EAR through a puncture in the TYMPANIC MEMBRANE. FX - Middle Ear Ventilation FX - Otitis Media MH - Type I Secretion Systems UI - D000069177 MN - D5.500.890.500.500 MS - Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.) HN - 2016 MH - Type II Secretion Systems UI - D000069178 MN - D5.500.890.500.750 MS - Gram-negative bacterial secretion systems which carry out the secretion of folded proteins.T2SSs secrete folded proteins from the PERIPLASMIC SPACE that have been exported there by SEC TRANSLOCASE or TAT SECRETION SYSTEMS, or they secrete folded proteins directly from the CYTOPLASM. The T2SSs have four substructures, an ATPase, an inner membrane platform, a pseudopilin, and secretin, an outer membrane complex which is a channel for secretion. (This bacterial secretin is not the same as the mammalian hormone also named SECRETIN.) HN - 2016 MH - Type III Secretion Systems UI - D000069296 MN - D5.500.890.500.875 MS - Multiprotein transmembrane complexes in GRAM-NEGATIVE BACTERIA involved in either the secretion of effector proteins from the bacterial cytoplasm into host cells, or the secretion and assembly of flagellar components. The major component of the T3SSs is called the injectosome or needle complex. HN - 2016 MH - Type IV Secretion Systems UI - D000069319 MN - D5.500.890.500.937 MS - Multiprotein complexes that transport single proteins, multiprotein complexes, and nucleoprotein complexes from the CYTOPLASM into the EXTRACELLULAR SPACE or into recipient cells. T4SSs are found in GRAM-NEGATIVE BACTERIA, while homologous components to T4SSs are found in GRAM-POSTIVE BACTERIA. HN - 2016 MH - Type V Secretion Systems UI - D000069320 MN - D5.500.890.500.968 MS - Secretion systems of GRAM-NEGATIVE BACTERIA (single membrane proteins or multiprotein complexes) that carry out secretion of proteins from the PERIPLASMIC SPACE to the EXTRACELLULAR SPACE via a beta-barrel transmembrane pore. There are several T5SS subtypes: T5aSS monomeric autotransporters, T5bSS two-partner secretions systems (TPSS), T5cSS trimeric autotransporters, T5dSS fused two-partner secretion systems, and T5eSS autotransporters with inverted domains. HN - 2016 MH - Type VI Secretion Systems UI - D000069376 MN - D5.500.890.500.984 MS - Multiprotein complexes in GRAM NEGATIVE BACTERIA that deliver effector proteins into eukaryotic or prokaryotic cells by a mechanism similar to the contractile tail of bacteriophages. They are composed of a cell envelope-spanning tube which is surrounded by a contractile sheath and tipped by a cell puncturing complex; a base plate structure that anchors the assembly to the cell envelope; and an ATPase involved in the sheath contraction and disassembly of the complex. HN - 2016 MH - Type VII Secretion Systems UI - D000069377 MN - D5.500.890.500.992 MS - Bacterial secretion systems found in bacteria that have a MYCOLIC ACID-containing outer membrane such as MYCOBACTERIACEAE; Corynebacteriaceae; and NOCARDIACEAE. These are also known as ESX secretion systems because the first to be discovered is involved in secreting major virulence factors EsxA and EsxB. There are several subtypes of T7SSs including ESX-1, ESX-2, ESX-3, ESX-4, and ESX-5 secretion systems. The subtypes share some core components including an inner membrane channel-forming ATPase complex, a membrane-anchored mycosin, and a second channel that spans the outer mycolic acid-containing membrane. HN - 2016 MH - Ultrasonic Waves UI - D000069453 MN - G1.750.770.776.891 MS - Oscillating sound wave with a frequency higher than the upper limit of the human hearing range. HN - 2016; for ULTRASOUND RADIATION use SOUND 2012-2015 FX - Ultrasonics MH - Underage Drinking UI - D000066608 MN - F1.145.22.750 MN - F1.145.317.269.875 MN - I1.880.735.878 MS - Consumption of ALCOHOLIC BEVERAGES by persons under the legal drinking age. HN - 2016 FX - Alcohol Drinking in College MH - Undocumented Immigrants UI - D000069756 MN - M1.189.500 MS - Foreign nationals residing in a country without legal immigration status, or in violation of the immigration laws of that country. HN - 2016 MH - Unilateral Breast Neoplasms UI - D000069584 MN - C4.588.180.682 MN - C17.800.90.500.682 MS - Tumors or cancer found specifically in one human BREAST, but not in both. AN - human only; coordinate IM with histological type of neoplasm (IM) HN - 2016 MH - Unsupervised Machine Learning UI - D000069558 MN - G17.35.250.500.750 MN - L1.224.50.375.530.750 MS - A MACHINE LEARNING paradigm used to make predictions about future instances based on a given set of unlabeled paired input-output training (sample) data. HN - 2016 FX - Supervised Machine Learning MH - Ustekinumab UI - D000069549 MN - D12.776.124.486.485.114.224.60.937 MN - D12.776.124.790.651.114.224.60.937 MN - D12.776.377.715.548.114.224.200.937 MS - A humanized monoclonal antibody that binds to IL-12 and IL-23 and is used as a DERMATOLOGIC AGENT in the treatment of patients with plaque PSORIASIS who have not responded to other therapies. HN - 2016 (2005) MH - Valsartan UI - D000068756 MN - D3.383.129.617.850 MN - D12.125.70.950.550 MN - D12.125.142.930.500 MS - A tetrazole derivative and ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKER that is used to treat HYPERTENSION. HN - 2016 (1993) FX - Losartan MH - Vardenafil Dihydrochloride UI - D000069058 MN - D3.383.129.308.980 MN - D3.383.606.960 MS - A piperazine derivative, PHOSPHODIESTERASE 5 INHIBITOR and VASODILATOR AGENT that is used as a UROLOGICAL AGENT in the treatment of ERECTILE DYSFUNCTION. HN - 2016 (2001) MH - Varenicline UI - D000068580 MN - D3.438.79.900 MN - D3.438.857.942 MS - A benzazepine derivative that functions as an ALPHA4/BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION. HN - 2016 (2005) FX - Tobacco Use Cessation Products MH - Vegans UI - D000066989 MN - M1.928.500 MS - Persons who avoid consuming animal products or animal-derived substances, such as MEAT; EGGS; or HONEY. Some vegans also refrain from using animals or animal products in any form or for any purpose, such as in CLOTHING or household goods. HN - 2016 FX - Diet, Vegan MH - Vegetable Products UI - D000067075 MN - G7.203.300.850.450 MN - J2.500.850.800 MS - Food that is manufactured from various parts of vegetables. HN - 2016 MH - Vegetarians UI - D000066988 MN - M1.928 MS - Persons who do not eat MEAT. HN - 2016 FX - Diet, Vegetarian MH - Venlafaxine Hydrochloride UI - D000069470 MN - D2.33.415.510.500.901 MN - D2.92.471.683.948 MN - D2.455.426.392.368.367.318.750 MN - D10.289.510.500.901 MS - A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. HN - 2016 (1986) MH - Vilazodone Hydrochloride UI - D000069503 MN - D3.383.606.980 MN - D3.438.127.818 MN - D3.438.473.957 MS - A benzofuran, indole, and piperazine derivative that functions as a SEROTONIN UPTAKE INHIBITOR and partial SEROTONIN 5-HT1 RECEPTOR AGONIST. It is used as an ANTIDEPRESSIVE AGENT. HN - 2016 (2004) MH - War Exposure UI - D000067453 MN - I1.880.735.950.500.951 MN - N6.850.460.350.600.903 MS - The health and other ramifications of military and civilian exposure to WAR . FX - Veterans Health MH - War-Related Injuries UI - D000067398 MN - C26.946 MN - I1.880.735.950.500.951.500 MN - N6.850.460.350.600.903.500 MS - WOUNDS and INJURIES and PSYCHOLOGICAL TRAUMA sustained during WAR. HN - 2016 FX - Stress Disorders, Post-Traumatic MH - Warfare and Armed Conflicts UI - D000068336 MN - I1.880.735.950 MS - Engaging in any type of conflict including war or military conflict against another nation or organized group.. AN - used for searching; INDEXER: Do not use; CATALOGER: Do not use HN - 2016 MH - Waterborne Diseases UI - D000069578 MN - C1.539.221.750 MS - Illnesses due to micro-organisms and chemicals in drinking water, those caused by organisms having part of their lifecycle in water or those with water-related vectors, and others spread by aerosols containing pathogens. HN - 2016 MH - Whey UI - D000067796 MN - G7.203.100.700.750 MN - G7.203.300.350.525.760 MN - J2.200.700.750 MN - J2.500.350.525.760 MS - The liquid components of milk that remain after the CASEIN, fat, and fat soluble components have been removed. It is also a byproduct of cheese production. HN - 2016 MH - Whey Proteins UI - D000067816 MN - D12.776.256.626.816 MN - G7.203.300.350.525.520.500 MN - G7.203.300.350.525.760.500 MN - G7.203.300.428.626.500 MN - J2.500.350.525.520.500 MN - J2.500.350.525.760.500 MN - J2.500.428.626.500 MS - The protein components of milk obtained from the whey. HN - 2016 (1984) MH - Whole Grains UI - D000067348 MN - G7.203.300.300.550.500 MN - G7.203.300.775.500.500 MN - J2.500.300.550.500 MN - J2.500.775.500.500 MS - Edible seeds which contain all components of the seed - germ, bran, and ENDOSPERM. HN - 2016 MH - Work Performance UI - D000066477 MN - I3.946.675 MS - Measure of how well someone performs given tasks at their place of work. HN - 2016 FX - Workplace MH - Working Poor UI - D000069602 MN - M1.987 MS - People who are in the labor force either working or looking for work for 27 weeks or more in a year, but whose income fall below a given poverty line. HN - 2016 FX - Poverty FX - Poverty Areas MH - Youth Sports UI - D000067009 MN - I3.450.642.845.987 MS - SPORTS activities designed and/or organized for CHILDREN or YOUTH. HN - 2016