MH - 17 alpha-Hydroxyprogesterone Caproate UI - D000077713 MN - D4.210.500.745.745.654.829.395.400.500 MN - D6.472.334.851.687.750.478.400.250 MS - Hydroxyprogesterone derivative that acts as a PROGESTIN and is used to reduce the risk of recurrent MISCARRIAGE and of PREMATURE BIRTH. It is also used in combination with ESTROGEN in the management of MENSTRUATION DISORDERS. HN - 2019 (1979) MH - 2-Methoxyestradiol UI - D000077584 MN - D4.210.500.365.415.248.830 MN - D6.472.334.851.437.500.750 MS - A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS. HN - 2019 (1980) MH - 5-Methoxypsoralen UI - D000078223 MN - D3.383.663.283.446.794.688 MN - D3.633.100.150.446.794.688 MN - D3.633.300.770.688 MS - A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS. HN - 2019 (1980) MH - Abciximab UI - D000077284 MN - D12.644.541.500.650.125 MN - D12.776.124.486.485.114.224.60.125 MN - D12.776.124.486.485.680.650.125 MN - D12.776.124.790.651.114.224.60.125 MN - D12.776.124.790.651.680.650.125 MN - D12.776.377.715.548.114.224.200.125 MN - D12.776.377.715.548.680.650.125 MS - A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. It is used in treatment of refractory unstable angina, and for prevention of ischemic complications in patients undergoing percutaneous coronary procedures such as ANGIOPLASTY; ATHERECTOMY; or stenting. HN - 2019 (1994) MH - Acamprosate UI - D000077443 MN - D2.455.326.146.100.850.438 MN - D2.886.645.600.55.850.400 MS - Structural analog of taurine that is used for the prevention of relapse in individuals with ALCOHOLISM. HN - 2019 (1985) MH - Adenocarcinoma of Lung UI - D000077192 MN - C4.557.470.200.25.22 MN - C4.588.894.797.520.55 MS - A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer. AN - coordinate IM with LUNG NEOPLASMS (IM) HN - 2019 (2009) MH - Adverse Childhood Experiences UI - D000076783 MN - I1.198.240.856.175 MN - I1.880.735.35 MN - I1.880.735.900.175 MN - I1.880.853.50 MS - Deleterious experiences in first 18 years of life. HN - 2019 MH - Aegilops UI - D000078065 MN - B1.650.940.800.575.912.250.822.17 MS - A genus of grasses known generally as goatgrasses, presumed to be wild ancestors of domestic WHEAT. They belong to the grass family, POACEAE, and are distributed widely in Eurasia and North America. HN - 2019 MH - Afatinib UI - D000077716 MN - D2.65.132 MN - D3.633.100.786.188 MS - A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER. HN - 2019 (2007) MH - Agammaglobulinaemia Tyrosine Kinase UI - D000077329 MN - D8.811.913.696.620.682.725.25 MS - A non-receptor tyrosine kinase that is essential for the development, maturation, and signaling of B-LYMPHOCYTES. It contains an N-terminal zinc finger motif and localizes primarily to the PLASMA MEMBRANE and nucleus of B-lymphocytes. Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA. HN - 2019 (1993) MH - Aggressive Driving UI - D000077314 MN - I1.880.735.223.125 MN - I3.125.150 MS - Combination of moving traffic offenses so as to endanger other persons or property. (https://nhtsa.gov/Driving-Safety/Aggressive-Driving) HN - 2019 MH - Alefacept UI - D000077944 MN - D12.776.124.486.485.114.619.393.131 MN - D12.776.124.790.651.114.619.393.131 MN - D12.776.377.715.548.114.619.393.131 MN - D12.776.395.550.34.500 MN - D12.776.543.550.158.500 MN - D12.776.828.300.100 MS - A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. It is used in the management of moderate to severe chronic plaque PSORIASIS. HN - 2019 (2000) MH - Alginic Acid UI - D000077322 MN - D2.241.81.844.915.162.249.500 MN - D2.241.81.844.915.400.250 MN - D2.241.152.811.162.500.500 MN - D2.241.152.811.400.250 MN - D2.241.511.902.915.162.500.500 MN - D2.241.511.902.915.400.250 MN - D9.698.68.500 MN - D9.811.922.162.500.500 MN - D9.811.922.400.250 MS - A polysaccharide and linear copolymer, consisting mainly of beta-1,4-linked D-mannuronic acid and alpha-1,4-linked L-glucuronic acid, that occurs in marine algae such as LAMINARIA, and in BIOFILMS produced by PSEUDOMONAS AERUGINOSA. HN - 2019 (1972) MH - Alitretinoin UI - D000077556 MN - D2.455.326.271.665.202.495.818.500.500 MN - D2.455.426.392.368.367.379.249.700.860.500.500 MN - D2.455.849.131.495.818.800.500 MN - D23.767.261.700.780.500 MS - A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA. HN - 2019 (1997) MH - Allogeneic Cells UI - D000078422 MN - A1.941.500.500 MN - A11.47 MS - Cells from genetically different individuals of the same species to be used for CELL- AND TISSUE-BASED THERAPY; ADOPTIVE CELL TRANSFER; or ADOPTIVE IMMUNOTHERAPY. HN - 2019 MH - Aluminum Chloride UI - D000077410 MN - D1.56.31 MN - D1.210.450.150.25 MS - A compound with the chemical formula AlCl3; the anhydrous salt is used as a catalyst in organic chemical synthesis, and hydrated salts are used topically as antiperspirants, and for the management of HYPERHYDROSIS. HN - 2019 (1975) MH - Amifampridine UI - D000077770 MN - D2.92.80.60.500 MN - D3.383.725.50.60.500 MS - 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES. HN - 2019 (1978) MH - Amisulpride UI - D000077582 MN - D2.65.277.34 MN - D2.241.223.100.100.110 MN - D2.455.426.559.389.127.85.84 MS - A benzamide derivative that is used as an antipsychotic agent for the treatment of schizophrenia. It is also used as an antidepressive agent. HN - 2019 (1976) MH - Anaplastic Lymphoma Kinase UI - D000077548 MN - D8.811.913.696.620.682.725.400.02 MN - D12.776.543.750.630.02 MS - A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA. HN - 2019 (1994) MH - Anastrozole UI - D000077384 MN - D2.626.218 MN - D3.383.129.799.275 MS - A nitrile and triazole derivative that acts as a selective nonsteroidal aromatase inhibitor. It is used in the treatment of ESTROGEN NUCLEAR RECEPTOR-positive breast cancer in postmenopausal women. HN - 2019 (1994) MH - Anidulafungin UI - D000077612 MN - D12.644.641.311.250 MS - Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS. HN - 2019 (1997) MH - Apium UI - D000077102 MN - B1.650.940.800.575.912.250.75.94 MS - A genus comprising several species of flowering plants with global distribution in the family APIACEAE. HN - 2019 BX - Apium graveolens BX - Celery MH - Aprepitant UI - D000077608 MN - D3.383.533.640.125 MS - A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING. HN - 2019 (1998) MH - Arsenic Trioxide UI - D000077237 MN - D1.75.38 MN - D1.650.550.125 MS - An inorganic compound with the chemical formula As2O3 that is used for the treatment of ACUTE PROMYELOCYTIC LEUKEMIA in patients who have relapsed from, or are resistant to, conventional drug therapy. HN - 2019 (1975) MH - Artemether UI - D000077549 MN - D1.248.497.158.685.750.212.250 MN - D1.339.431.374.212.250 MN - D1.650.550.750.200.250 MN - D2.389.338.55.250 MN - D2.455.849.765.211.250 MS - An artemisinin derivative that is used in the treatment of MALARIA. HN - 2019 (1982) MH - Artemether, Lumefantrine Drug Combination UI - D000077611 MN - D1.248.497.158.685.750.212.250.500 MN - D1.339.431.374.212.250.500 MN - D1.650.550.750.200.250.500 MN - D2.389.338.55.250.500 MN - D2.455.426.559.847.389.650.500 MN - D2.455.849.765.211.250.500 MN - D4.615.389.650.500 MN - D26.310.110 MS - Drug combination of artemether and lumefantrine that is used to treat PLASMODIUM FALCIPARUM MALARIA. HN - 2019 (2006) MH - Artesunate UI - D000077332 MN - D1.248.497.158.685.750.212.500 MN - D1.339.431.374.212.500 MN - D1.650.550.750.200.500 MN - D2.389.338.55.500 MN - D2.455.849.765.211.500 MS - A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities HN - 2019 (1983) MH - Atrasentan UI - D000077868 MN - D3.383.246.118.300 MN - D3.383.773.79 MN - D3.633.100.115.300 MS - A pyrrolidine and benzodioxole derivative that acts a RECEPTOR, ENDOTHELIN A antagonist. It has therapeutic potential as an antineoplastic agent and for the treatment of DIABETIC NEPHROPATHIES. HN - 2019 (1996) MH - Austrobaileyales UI - D000076667 MN - B1.650.940.800.575.912.250.103 MS - Order of woody flowering plants which grow as trees and shrubs that include the genera, Illicium and Schisandra. HN - 2019 MH - Axitinib UI - D000077784 MN - D2.65.277.51 MN - D2.241.223.100.100.115 MN - D2.455.426.559.389.127.85.93 MN - D3.383.129.539.487.65 MN - D3.633.100.449.65 MS - A benzamide and indazole derivative that acts as a TYROSINE KINASE inhibitor of the VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR. It is used in the treatment of advanced RENAL CELL CARCINOMA. HN - 2019 (2005) MH - Basiliximab UI - D000077552 MN - D12.776.124.486.485.114.224.60.344 MN - D12.776.124.790.651.114.224.60.407 MN - D12.776.377.715.548.114.224.200.407 MS - A chimeric murine-human monoclonal antibody that functions as an INTERLEUKIN 2 RECEPTOR antagonist by binding to the alpha chain (CD25 ANTIGEN) of the interleukin-2 receptor on the surface of activated T-LYMPHOCYTES. It is used in the prevention of acute graft rejection episodes in patients undergoing renal transplantation. HN - 2019 (1998) MH - Becaplermin UI - D000077214 MN - D12.644.276.910.650.500 MN - D12.776.260.690.500 MN - D12.776.467.910.650.500 MN - D23.529.910.650.500 MS - A recombinant human platelet-derived growth factor B-chain dimer used to promote WOUND HEALING by stimulating PHYSIOLOGIC ANGIOGENESIS. HN - 2019 (1992) MH - Bexarotene UI - D000077610 MN - D2.455.326.271.665.202.495.150 MN - D2.455.426.392.368.367.379.249.700.135 MN - D2.455.426.559.847.638.960.423 MN - D2.455.849.131.495.150 MN - D4.615.638.960.423 MS - A tetrahydronaphthalene derivative and RETINOID X RECEPTOR antagonist that is used in the treatment of CUTANEOUS T-CELL LYMPHOMA. HN - 2019 (1995) MH - Big Data UI - D000077558 MN - L1.313.500.750.300.92 MS - Extremely large amounts of data which require rapid and often complex computational analyses to reveal patterns, trends, and associations, relating to various facets of human and non-human entities. HN - 2019 FX - Data Mining FX - Data Science FX - Datasets as Topic MH - Biomineralization UI - D000077320 MN - G2.111.92 MN - G7.345.155 MN - G7.345.500.325.377.625.50 MN - G11.427.578.50 MS - Process by which living organisms produce MINERALS that accumulate into hardened tissues (e.g., bones, teeth and shells), and cellular nanostructures that sequester away into macromolecules. Biosynthesized minerals include CALCIUM CARBONATE; FLUOROAPATITE; HYDROXYAPATITE; and MAGNETITE. HN - 2019 MH - Birth Setting UI - D000077085 MN - G8.686.784.769.490.62 MS - Physical setting or location of birth. HN - 2019 MH - Body-Weight Trajectory UI - D000077962 MN - C23.888.144.243.463 MN - G7.345.249.314.120.200.463 MS - A general pattern of body weight gain or loss over many years. Weight change trajectory is influenced by several determinants in children and adults. HN - 2019 MH - Bone-Anchored Prosthesis UI - D000077280 MN - E7.695.118 MS - A prosthesis designed to attach directly to the bone via fixtures implanted into the bone rather than a socket. HN - 2019 FX - Osseointegration MH - Bosentan UI - D000077300 MN - D2.65.884.135 MN - D2.886.590.700.143 MN - D3.383.742.60 MS - A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS. HN - 2019 (1994) MH - Brugmansia UI - D000076609 MN - B1.650.940.800.575.912.250.908.500.97 MS - A small to mid-size tree with large, strong-smelling, trumpet-shaped flowers hanging downward. Most parts of the plant contain ATROPINE, SCOPOLAMINE HYDROBROMIDE and HYOSCAYAMINE. It is used as poisons and medicines in S. America. HN - 2019(2002); use SOLANACEAE 2002-2018 MH - Built Environment UI - D000076624 MN - N6.230.145.500 MS - The man-made physical elements of the environment (e.g., homes, buildings, streets, open spaces, and infrastructure). The built environment influences a person's level of physical activity and may have other impacts on health in a community. HN - 2019 MH - Burnout, Psychological UI - D000077062 MN - F1.145.126.990.367 MN - F2.830.900.333 MS - An excessive reaction to stress caused by one's environment that may be characterized by feelings of emotional and physical exhaustion, coupled with a sense of frustration and failure. HN - 2019 FX - Karoshi Death MH - Cabergoline UI - D000077465 MN - D3.132.327.287.131 MN - D3.633.400.439.197 MS - An ergoline derivative and dopamine D2-agonist that inhibits PROLACTIN secretion. It is used in the management of HYPERPROLACTINEMIA, and to suppress lactation following childbirth for medical reasons. Cabergoline is also used in the management of PARKINSON DISEASE. HN - 2019 (1985) MH - Calcitonin Gene-Related Peptide Receptor Antagonists UI - D000077221 MN - D27.505.519.270 MN - D27.505.696.663.850.14.610 MN - D27.505.954.427.40.409 MS - Pharmacologic agents that block NOCICEPTIVE PAIN signaling from CALCITONIN GENE-RELATED PEPTIDE RECEPTORS. They may be useful for the treatment of pain associated with MIGRAINE DISORDERS and OSTEOARTHRITIS. HN - 2019 FX - Receptors, Calcitonin Gene-Related Peptide MH - Calcium Aluminosilicate UI - D000077250 MN - D1.56.50.75.225 MN - D1.578.725.25.225 MN - D1.650.550.50.75.225 MN - D1.837.725.700.760.50.250 MS - Aluminosilicate salts of calcium, the most common of which are CaAl2Si2O8 and Ca2Al2SiO7; a naturally occurring form in CLAY may be used to treat DIARRHEA. HN - 2019 (2015) FX - Clay MH - Calcium-Regulating Hormones and Agents UI - D000077264 MN - D27.505.696.260 MS - Hormones and molecules with calcium regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis. HN - 2019 MH - Carbamide Peroxide UI - D000077463 MN - D1.248.497.158.685.750.318 MN - D1.339.431.374.318 MN - D1.650.550.750.300 MN - D2.389.338.154 MN - D2.948.278 MS - A urea peroxide compound that is commonly used in tooth whitening agents; topical anti-infective agents, and earwax remover. HN - 2019 (1969) MH - Carbon Fiber UI - D000077482 MN - D1.268.150.38 MN - D5.750.139 MN - D25.720.150 MN - J1.637.51.720.150 MS - Fiber with a diameter of approximately 5 to 10 micrometers that is composed mostly of carbon atoms. It has a variety of applications. HN - 2019 (1978) MH - Carcinoma, Ovarian Epithelial UI - D000077216 MN - C4.557.470.200.295 MN - C4.588.322.455.199 MN - C13.351.500.56.630.705.350 MN - C13.351.937.418.685.350 MN - C19.344.410.199 MN - C19.391.630.705.350 MS - A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer. AN - coordinate IM with OVARIAN NEOPLASMS (IM) HN - 2019 (2010) MH - Carvedilol UI - D000077261 MN - D2.33.100.624.151 MN - D2.33.755.624.151 MN - D2.92.63.624.151 MN - D3.633.100.473.144.125 MN - D3.633.300.148.125 MS - A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION. HN - 2019 (1984) MH - Caspian Sea UI - D000077228 MN - G1.311.580.500 MS - The largest inland body of water, located between ASIA and EUROPE. HN - 2019 MH - Caspofungin UI - D000077336 MN - D10.477.250 MN - D12.644.365.250 MN - D12.644.641.311.500 MS - A cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic MYCOSES. HN - 2019 (1997) MH - Catalog, Commercial UI - D000078925 MN - V2.240.100 MS - Lists of merchandise for sale. AN - This heading is used as a Publication Type. Works on Commercial Catalogs as a subject are indexed under the main heading CATALOGS, COMMERCIAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Catalog, Drug UI - D000078903 MN - V2.240.125 MS - Lists of drugs for sale. AN - This heading is used as a Publication Type. Works on Drug Catalogs as a subject are indexed under the main heading CATALOGS, DRUG AS TOPIC. INDEXER: Do not use HN - 2019 MH - Catalog, Union UI - D000078922 MN - V2.240.313 MS - Lists of books and other information sources held among a cooperating group of LIBRARIES. AN - This heading is used as a Publication Type. Works on Union Catalogs as a subject are indexed under the main heading CATALOGS, UNION AS TOPIC. INDEXER: Do not use HN - 2019 MH - Cauda Equina Syndrome UI - D000077684 MN - C10.668.829.550.350 MN - C10.668.829.800.750.150 MS - Compressive lesion affecting the nerve roots of the CAUDA EQUINA (e.g., compression, herniation, inflammation, rupture, or stenosis), which controls the function of the bladder and bowel. Symptoms may include neurological dysfunction of bladder or bowels, loss of sexual sensation and altered sensation or paralysis in the lower extremities. HN - 2019; use Polyradiculopathy 2010-2018 MH - Cefdinir UI - D000077525 MN - D2.65.589.99.249.169 MN - D2.886.665.74.169 MN - D3.633.100.300.249.169 MS - A third-generation oral cephalosporin antibacterial agent that is used to treat bacterial infections of the respiratory tract and skin. HN - 2019 (1988) MH - Cefepime UI - D000077723 MN - D2.65.589.99.249.173 MN - D2.886.665.74.173 MN - D3.633.100.300.249.173 MS - A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA. HN - 2019 (1985) MH - Ceftibuten UI - D000077722 MN - D2.65.589.99.249.187 MN - D2.886.665.74.187 MN - D3.633.100.300.249.187 MS - A cephalosporin antibacterial agent that is used in the treatment of infections, including urinary-tract and respiratory-tract infections. HN - 2019 (1988) MH - Cetrimonium UI - D000077286 MN - D2.92.877.883.111.500 MN - D2.675.276.190.500 MS - Cetyltrimethylammonium compound whose salts and derivatives are used primarily as topical antiseptics. HN - 2019 (1969) MH - Change Management UI - D000078003 MN - N4.452.610.125 MS - Processes, tools, and techniques involved in the management of ORGANIZATIONAL INNOVATION, the purpose of which is to help individuals and work groups make successful personal transitions which ensure overall successful outcomes. HN - 2019 MH - Child Labor UI - D000078463 MN - I1.880.735.105 MN - N1.824.245.263 MS - Employment of MINORS in work that deprives children of their childhood, potential, dignity, and is harmful to their physical and mental development. (International Labor Organization, UN) HN - 2019; see Employment 1979-2018 MH - Chlorophyceae UI - D000077105 MN - B1.650.940.150.511 MS - A class of green algae in the subdivision CHLOROPHYTINA distinguished by its ultrastructural morphology. Some species have distinct arrangement of flagella. HN - 2019 BX - Chlamydomonadales MH - Chlorophyll A UI - D000077194 MN - D3.383.129.578.840.374.140 MN - D3.383.129.578.840.500.640.220.140 MN - D3.633.400.909.374.140 MN - D3.633.400.909.500.640.220.140 MN - D4.345.783.374.140 MN - D4.345.783.500.640.220.140 MN - D23.767.727.640.220.140 MS - A form of chlorophyll that absorbs light in the violet to red spectrum (approximately 400-700 nm wavelength range) and reflects green light (500-570 nm wavelength), which imparts the characteristic green color to land plants. It is essential for oxygenic PHOTOSYNTHESIS. HN - 2019 (1981) MH - Chondrosarcoma, Clear Cell UI - D000077207 MN - C4.557.450.565.280.140 MN - C4.557.450.795.300.140 MS - A chondrosarcoma of adolescence to old age of the proximal EPIPHYSES of long bones. It has variably clear cytoplasm of the mostly neoplastic CHONDROCYTES with little intervening matrix. AN - coordinate IM with BONE NEOPLASMS (IM) or specific precoordinated bone/neoplasm term (IM) or specific bone (IM) + BONE NEOPLASMS (IM) HN - 2019 MH - Ciclopirox UI - D000077768 MN - D2.455.426.392.368.367.95 MN - D3.383.725.791.199 MS - A cyclohexane and pyridinone derivative that is used for the treatment of fungal infections of the skin and nails, and for treatment of VAGINAL YEAST INFECTIONS. HN - 2019 (1976) MH - Cidofovir UI - D000077404 MN - D2.705.429.437 MN - D3.383.742.698.421.216 MS - An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS. HN - 2019 (1989) MH - Cilastatin, Imipenem Drug Combination UI - D000077728 MN - D2.65.589.99.124.300.500.500 MN - D2.455.426.392.368.533.200.500 MN - D3.633.100.300.124.300.500.500 MN - D10.251.355.325.200.500 MN - D26.310.356 MS - Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent. HN - 2019 (1985) MH - Cilostazol UI - D000077407 MN - D3.383.129.617.293 MN - D3.633.100.810.69 MS - A quinoline and tetrazole derivative that acts as a phosphodiesterase type 3 inhibitor, with anti-platelet and vasodilating activity. It is used in the treatment of PERIPHERAL VASCULAR DISEASES; ISCHEMIC HEART DISEASE; and in the prevention of stroke. HN - 2019 (1985) MH - Ciona UI - D000077262 MN - B1.50.150.200.727.150 MN - B1.50.500.272.727.150 MS - A genus of SEA SQUIRTS in the family Cionidae. HN - 2019 MH - Clay UI - D000077215 MN - D20.721.250 MN - G1.311.820.250 MN - G16.500.275.815.250 MN - N6.230.600.250 MS - A naturally occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter. HN - 2019 (1976) FX - Calcium Aluminosilicate MH - Clinical Observation Units UI - D000076542 MN - N2.278.388.75 MS - A hospital unit that serves as a dedicated observation area for emergency room patients when a decision to admit or not is unclear. Also known as clinical decision units or short-stay observation units. HN - 2019 MH - Clinical Trial Protocol UI - D000078325 MN - V3.175.313 MS - The written description of a clinical study. It contains the study's objectives, design, and methods including subject target and/or enrollment criteria. It may also present relevant scientific background and statistical information. AN - this heading is used as a Publication Type; for original report of the clinical trial protocol; a different heading CLINICAL TRIAL PROTOCOLS AS TOPIC is used for general design, methodology, economics, etc. of clinical trial protocols; do not confuse with CLINICAL PROTOCOLS; coordinate with the specific Clinical Trial Publication Type if pertinent HN - 2019 MH - Clinical Trial Protocols as Topic UI - D000078985 MN - N5.715.360.330.125.625 MS - Works about the written descriptions of a clinical study. It contains the study's objectives, design, and methods including subject target and/or enrollment criteria. It may also present relevant scientific background and statistical information. AN - do not confuse with the Publication Type CLINICAL TRIAL PROTOCOL or with CLINICAL PROTOCOLS HN - 2019 MH - Clinical Trial, Veterinary UI - D000077522 MN - V3.175.375 MS - A work that is a veterinary clinical study in which animal participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Animal participants may receive diagnostic, therapeutic, or other types of interventions. AN - this heading is used as a Publication Type; for original report of the conduct or results of a specific veterianry clinical trial; a different heading CLINICAL TRIALS, VETERINARY AS TOPIC is used for general design, methodology, economics, etc. of veterinary clinical trials HN - 2019 MH - Clinical Trials, Veterinary as Topic UI - D000078665 MN - E5.318.372.250.375 MN - N5.715.360.330.250.375 MN - N6.850.520.450.250.375 MS - Works about clinical studies in which animal participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Animal participants may receive diagnostic, therapeutic, or other types of interventions. AN - for general design, methodology, economics, etc. of veterinary clinical trials; a different heading CLINICAL TRIAL, VETERINARY is used for reports of a specific veterinary clinical trial HN - 2019 MH - Clobazam UI - D000078306 MN - D3.633.100.79.80.165 MS - A benzodiazepine derivative that is a long-acting GABA-A RECEPTOR agonist. It is used as an antiepileptic in the treatment of SEIZURES, including seizures associated with LENNOX GASTAUT SYNDROME. It is also used as an anxiolytic, for the short-term treatment of acute ANXIETY. HN - 2019 (1976) MH - Clofarabine UI - D000077866 MN - D3.633.100.759.646.138.309 MN - D13.570.65.195 MN - D13.695.667.138.309 MN - D13.695.827.68.309 MS - An adenine arabinonuceloside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed. HN - 2019 (1991) MH - Clopidogrel UI - D000077144 MN - D2.886.778.823.500.500 MN - D3.383.725.849.500.500 MN - D3.383.903.830.500.500 MN - D3.633.100.928.500.500 MS - A ticlopidine analog and platelet purinergic P2Y receptor antagonist that inhibits adenosine diphosphate-mediated PLATELET AGGREGATION. It is used to prevent THROMBOEMBOLISM in patients with ARTERIAL OCCLUSIVE DISEASES; MYOCARDIAL INFARCTION; STROKE; or ATRIAL FIBRILLATION. HN - 2019 (1988) MH - Collaborative Cross Mice UI - D000076724 MN - B1.50.150.900.649.313.992.635.505.500.400.13 MS - Recombinant inbred strains of mice derived from an eight-way cross of eight genetically diverse, founder inbred strains, as a reference population for analyzing MULTIFACTORIAL INHERITANCE. HN - 2019 MH - Collections as Topic UI - D000078662 MN - L1.470.375 MS - Works about items gathered and assembled in some order to facilitate access or use. AN - do not confuse with the Publication Type COLLECTION HN - 2019 MH - Cone Dystrophy UI - D000077765 MN - C11.270.151 MN - C11.768.216 MS - A general term which describes a group of rare eye disorders that affect the cone cells of the RETINA. Cone dystrophy can cause a variety of symptoms including decreased visual clarity or acuity when looking straight ahead (central vision), a reduced ability to see colors, and an increased sensitivity to light (PHOTOPOBIA). HN - 2019 MH - Conscientious Refusal to Treat UI - D000078383 MN - N4.590.233.727.605.500 MN - N5.300.100.675.500 MS - Refusal of health professionals to provide medical services on the basis of moral or religious beliefs. MH - Correlation of Data UI - D000078331 MN - H1.548.832.500 MS - Determination of whether or not two variables are correlated. This means to study whether an increase or decrease in one variable corresponds to an increase or decrease in the other variable. HN - 2019(1979) MH - Craniofacial Fibrous Dysplasia UI - D000077275 MN - C5.116.99.708.375.286 MS - Mostly benign fibro-osseous proliferation of the facial bone and skull. It can be either monostotic (localized to a single bone) or polyostotic (localized to more than one bone) type. HN - 2019 MH - CRISPR-Associated Protein 9 UI - D000076987 MN - D8.811.277.352.355.325.150 MN - D12.776.97.219 MN - D12.776.212.500 MS - An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9. HN - 2019 FX - CRISPR-Cas Systems FX - Gene Editing MH - Crizotinib UI - D000077547 MN - D3.383.621.154 MN - D3.383.725.50.263 MS - A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER. HN - 2019 (2010) MH - Crystalloid Solutions UI - D000077324 MN - D26.776.498.500 MS - Isotonic solutions of mineral salts, such as RINGER'S LACTATE and SODIUM CHLORIDE (SALINE SOLUTION), used in FLUID THERAPY to rehydrate BLOOD VOLUME. HN - 2019 (1974) MH - Cyberbullying UI - D000077224 MN - F1.145.126.125.550.500 MN - F1.145.813.213.500.500 MN - I1.880.735.70.500 MS - Bullying that takes place over digital devices like cell phones and computers. It includes sending, posting, or sharing negative, harmful, false, or mean content about someone else. It can include sharing personal or private information about someone else causing embarrassment or humiliation. (from https://www.stopbullying.gov) HN - 2019; use Bullying 2018 MH - Cytoglobin UI - D000078842 MN - D12.776.422.316.381 MS - A globin protein that may protect cells from OXIDATIVE STRESS and function in intracellular oxygen storage and transfer. HN - 2019 (2002) MH - Daclizumab UI - D000077561 MN - D12.776.124.486.485.114.224.60.766 MN - D12.776.124.790.651.114.224.60.766 MN - D12.776.377.715.548.114.224.200.766 MS - An anti-TAC (INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT) humanized monoclonal antibody (immunoglobulin G1 disulfide with human-mouse monoclonal clone 1H4 light chain, dimer) that is used in the treatment of ACUTE RELAPSING MULTIPLE SCLEROSIS. HN - 2019 (1995) MH - Daphniphyllaceae UI - D000076608 MN - B1.650.940.800.575.912.250.890.500 MS - Vascular plants of the order SAXIFRAGALES, class MAGNOLIOPSIDA, of which the sole genus is DAPHNIPHYLLUM. HN - 2019 MH - Daphniphyllum UI - D000076482 MN - B1.650.940.800.575.912.250.890.500.500 MS - Broad-leaved evergreen shrub or small tree comprising several species. It is the only genus of the family DAPHNIPHYLLACEAE, class MAGNOLIOPSIDA. HN - 2019 MH - Data Aggregation UI - D000078303 MN - L1.399.250.213 MS - Process of searching, gathering, and presenting data in a summarized format. HN - 2019 MH - Data Analysis UI - D000078332 MN - H1.548.338 MS - Process of systematically applying statistical and/or logical techniques to describe and illustrate, condense and recap, and evaluate data (https://ori.hhs.gov/education). HN - 2019 MH - Data Science UI - D000077488 MN - L1.305 MS - An interdisciplinary field involving processes, theories, concepts, tools, and technologies, that enable the review, analysis, and extraction of valuable knowledge and information from structured and unstructured (raw) data. HN - 2019 FX - Big Data FX - Data Mining MH - Data Systems UI - D000078327 MN - L1.224.68.500 MS - Organized collection of symbols and symbol-manipulating processes used to operate on such symbols. HN - 2019 MH - Data Visualization UI - D000078326 MN - L1.143.288 MS - Facilitating understanding of the significance of data by placing it in a visual context. Patterns, trends and correlations that might go undetected in text-based data may be exposed and recognized easier. HN - 2019 MH - Decitabine UI - D000077209 MN - D2.145.150.500 MN - D3.383.742.680.245.217.500 MN - D13.570.685.245.217.500 MN - D13.570.800.286.300.500 MS - An azacitidine derivative and antineoplastic antimetabolite. It inhibits DNA methyltransferase to re-activate silent genes, limiting METASTASIS and NEOPLASM DRUG RESISTANCE. Decitabine is used in the treatment of MYELODISPLASTIC SYNDROMES, and ACUTE MYELOID LEUKEMIA. HN - 2019 (1977) FX - Cytarabine MH - Deep Learning UI - D000077321 MN - G17.35.250.500.250 MN - G17.485.500 MN - L1.224.50.375.530.250 MN - L1.224.50.375.605.500 MS - Supervised or unsupervised machine learning methods that use multiple layers of data representations generated by nonlinear transformations, instead of individual task-specific ALGORITHMS, to build and train neural network models. HN - 2019 MH - Deferasirox UI - D000077588 MN - D2.241.223.100.250 MN - D2.455.426.559.389.127.266 MN - D3.383.129.799.363 MS - A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA. HN - 2019 (2000) MH - Deferiprone UI - D000077543 MN - D3.383.725.791.298 MS - A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA. HN - 2019 (1985) MH - Density Functional Theory UI - D000077318 MN - H1.671.579.800.500 MS - Density functional theory is an approach to describe the electronic ground state properties of matter. It is a method of obtaining a solution to the Schrodinger equation for a many-body system, and is used to investigate the structural, magnetic, and electronic properties of molecules and materials. HN - 2019 MH - Desflurane UI - D000077335 MN - D2.355.417.166 MN - D2.355.601.325 MN - D2.455.526.510.213 MS - A fluorinated ether that is used as a volatile anesthetic for maintenance of general anesthesia. HN - 2019 (1987) MH - Desulfovibrionales UI - D000076642 MN - B3.660.125.144 MS - An order of bacteria within the class DELTAPROTEOBACTERIA, of the phylum PROTEOBACTERIA, which comprises four families. HN - 2019 MH - Diagnostic Screening Programs UI - D000076862 MN - N2.421.726.233.138 MS - Services for the presumptive identification of unrecognized disease in an apparently healthy, asymptomatic population by means of tests, examinations or other procedures that can be applied rapidly and easily to the target population. (from World Health Organization http://www.who.int/cancer/prevention/diagnosis-screening/screening/en/ Oct. 24,2017) HN - 2019 MH - Dialectical Behavior Therapy UI - D000077252 MN - F4.754.137.628 MS - A flexible, stage-based therapy that combines principles of behavior therapy, cognitive behavior therapy, and MINDFULNESS. It concurrently promotes acceptance and change, especially with difficult-to-treat patients. HN - 2019 MH - Diary as Topic UI - D000078646 MN - K1.517.211.361 MS - Works on or about records, usually private, of writers' experiences, observations, feelings, attitudes, etc. They may also be works marked in calendar order in which to note appointments and the like. HN - 2019 MH - Dicentra UI - D000076625 MN - B1.650.940.800.575.912.250.836.500.343 MS - A genus of herbaceous plants with asymmetrically-shaped flowers and finely divided leaves, native to east Asia and North America. HN - 2019 MH - Dictionary, Chemical UI - D000077844 MN - V2.310.113 MS - A reference book containing a list of words related to chemistry-usually in alphabetic order-giving information about form, pronunciation, etymology, grammar, and meaning. AN - This heading is used as a Publication Type. Works on Chemical Dictionaries as a subject are indexed under the main heading DICTIONARIES, CHEMICAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Dictionary, Classical UI - D000077803 MN - V2.310.225 MS - A reference work containing a list of words related to the Greco-Roman World giving information about form, pronunciation, etymology, grammar, and meaning. AN - This heading is used as a Publication Type. Works on Classical Dictionaries as a subject are indexed under the main heading DICTIONARIES, CLASSICAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Dictionary, Dental UI - D000077824 MN - V2.310.363 MS - A reference book containing a list of words related to dentistry-usually in alphabetic order-giving information about form, pronunciation, etymology, grammar, and meaning. AN - This heading is used as a Publication Type. Works on Dental Dictionaries as a subject are indexed under the main heading DICTIONARIES, DENTAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Dictionary, Medical UI - D000077823 MN - V2.310.400 MS - A reference book containing a list of words related to medicine-usually in alphabetic order-giving information about form, pronunciation, etymology, grammar, and meaning. AN - This heading is used as a Publication Type. Works on Medical Dictionaries as a subject are indexed under the main heading DICTIONARIES, MEDICAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Dictionary, Pharmaceutic UI - D000077825 MN - V2.310.450 MS - A reference book containing a list of words related to pharmacy-usually in alphabetic order-giving information about form, pronunciation, etymology, grammar, and meaning. AN - This heading is used as a Publication Type. Works on Pharmaceutic Dictionaries as a subject are indexed under the main heading DICTIONARIES, PHARMACEUTIC AS TOPIC. INDEXER: Do not use HN - 2019 MH - Disability Studies UI - D000077109 MN - I2.158.405.500 MS - Interdisciplinary programs of academic study that de-stigmatize disease, illness, and impairment. HN - 2019 MH - Disenfranchised Grief UI - D000076605 MN - F1.470.142.110.500 MS - Expression of grief that society limits or may not allow a person to express. Examples include the grief of parents for stillborn babies, of teachers for the death of students, of nurses for the death of patients, or for the loss of an animal companion. (from APA Dictionary of Psychology, 2nd ed.) HN - 2019 MH - Disgust UI - D000078382 MN - F1.470.307 MS - A feeling of revulsion or strong disapproval aroused by something unpleasant or offensive. HN - 2019 MH - Dispensatory UI - D000077202 MN - V2.314 MS - Systematic description of the drugs and preparations used generally or in a specific setting. AN - This heading is used as a Publication Type. Dispensatories as a subject are indexed under the main heading DISPENSATORIES AS TOPIC. INDEXER: do not use HN - 2019 MH - Diterpene Alkaloids UI - D000077743 MN - D2.455.849.291.184 MN - D3.132.301 MS - A class of nitrogenous organic compounds of plant origin composed of two TERPENES with molecular formula C20H32. HN - 2019 MH - Docetaxel UI - D000077143 MN - D2.455.426.392.368.242.888.389 MN - D2.455.849.291.850.389 MS - A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER. HN - 2019 (1991) MH - Donepezil UI - D000077265 MN - D2.455.426.559.847.486.487.280 MN - D3.383.621.238 MN - D4.615.486.487.280 MS - An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE. HN - 2019 (1992) MH - Doripenem UI - D000077726 MN - D2.65.589.99.124.150 MN - D3.633.100.300.124.150 MS - A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS. HN - 2019 (1996) MH - Dronedarone UI - D000077764 MN - D3.633.100.127.75.500 MS - A non-iodinated derivative of amiodarone that is used for the treatment of ARRHYTHMIA. HN - 2019 (1999) MH - Drug Development UI - D000076722 MN - E5.290 MN - H1.158.703.07.338 MN - H1.181.466.338 MS - The entire process of bringing a new drug to the market. It includes both preclinical and clinical testing, and regulatory approval. AN - do not confuse with DRUG DISCOVERY which is the process of finding chemicals for potential therapeutic use HN - 2019 MH - Economic Status UI - D000078022 MN - I1.880.853.996.268 MN - N1.824.98 MS - Personal or family variables such as household income, assets such as inherited wealth, savings, employment benefits, or ownership of homes or other property. HN - 2019 MH - Edaravone UI - D000077553 MN - D3.383.129.539.850.88.500 MS - An antipyrine derivative that functions as a free radical scavenger and neuroprotective agent. It is used in the treatment of AMYOTROPHIC LATERAL SCLEROSIS and STROKE. HN - 2019 (1970) MH - Egocentrism UI - D000078663 MN - F1.752.343 MN - F1.752.747.792.379 MS - Self-centered preoccupation or concern regarding one's own needs, abilities, wishes, desires, or preferences. AN - EGO is also available HN - 2019 MH - Embarrassment UI - D000078385 MN - F1.470.483.666.500 MS - A feeling of self-consciousness, shame, or awkwardness. HN - 2019 MH - Endurance Training UI - D000076663 MN - E2.760.169.63.500.387.250 MN - E2.779.483.250 MN - E2.831.535.483.250 MN - G11.427.410.698.277.311.188 MN - I3.350.311.188 MS - Exercise programs of relatively long duration and moderate intensity, which enhance maximal oxygen uptake, increasing PHYSICAL STAMINA. HN - 2019 FX - Physical Endurance MH - Enfuvirtide UI - D000077560 MN - D12.644.541.250 MN - D12.776.543.512.500.330.500 MN - D12.776.964.775.325.164.200.500 MN - D12.776.964.775.562.500.200.500 MN - D12.776.964.970.880.325.164.200.500 MN - D12.776.964.970.880.910.330.500 MN - D23.50.327.520.330.500 MS - A synthetic 36-amino acid peptide that corresponds to the heptad repeat sequence of HIV-1 gp41. It blocks HIV cell fusion and viral entry and is used with other anti-retrovirals for combination therapy of HIV INFECTIONS and AIDS. HN - 2019 (1997) MH - Enrofloxacin UI - D000077422 MN - D3.633.100.810.835.322.304 MS - A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice. HN - 2019 (1987) MH - Epidermal Cells UI - D000078404 MN - A11.409 MS - Cells from the outermost, non-vascular layer (EPIDERMIS) of the skin. AN - for epidermal cells of plants use PLANT EPIDERMIS /cytol HN - 2019 MH - Eplerenone UI - D000077545 MN - D2.540.383 MN - D4.210.500.745.745.329 MS - A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION. HN - 2019 (2000) MH - Eptifibatide UI - D000077542 MN - D12.644.641.366 MS - Cyclic peptide that acts as a platelet glycoprotein IIB-IIIA antagonist, reversibly inhibiting the binding of FIBRINOGEN; VON WILLEBRAND FACTOR; and other adhesive molecules to the GPIIB-IIA RECEPTORS of platelets. It is used in the management of UNSTABLE ANGINA and in patients undergoing coronary ANGIOPLASTY and stenting procedures. HN - 2019 (1994) MH - Equipment and Supplies Utilization UI - D000078338 MN - E5.318.740.375 MN - N5.715.360.750.338 MS - Extent of use of equipment or supplies. It includes overuse and underuse. HN - 2019 MH - Ertapenem UI - D000077727 MN - D2.65.589.99.124.225 MN - D3.633.100.300.124.225 MS - A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of Gram-positive and Gram-negative bacterial infections including intra-abdominal infections, acute gynecological infections, complicated urinary tract infections, skin infections, and respiratory tract infections. It is also used to prevent infection in colorectal surgery. HN - 2019 (2002) MH - Esophageal Squamous Cell Carcinoma UI - D000077277 MN - C4.557.470.200.400.330 MN - C4.557.470.700.400.565 MN - C4.588.274.476.205.500 MN - C4.588.443.353.500 MN - C6.301.371.205.500 MN - C6.405.117.430.500 MN - C6.405.249.205.500 MS - A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large POLYPLOID lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer. AN - coordinate IM with ESOPHAGEAL NEOPLASMS (IM) HN - 2019 (2012) MH - Etoricoxib UI - D000077613 MN - D2.886.590.444 MN - D3.383.725.354 MS - A sulfone and pyridine derivative that acts as a cyclooxygenase-2 inhibitor. It is used as a NSAID for the treatment of pain associated with RHEUMATOID ARTHRITIS and ANKYLOSING SPONDYLITIS. It is also used for the short-term treatment of moderate postoperative dental pain. HN - 2019 (2001) MH - Eucalyptol UI - D000077591 MN - D2.33.415.510.500.454 MN - D2.455.426.392.368.367.318.625 MN - D2.455.849.575.250 MN - D10.289.510.500.454 MS - A monoterpene and cyclohexanol derivative that is the major component of EUCALYPTUS OIL. It is used in mouthwash, insect repellent, and as a cough suppressant, and also is widely used as a flavoring agent and solvent. It has antimicrobial properties. HN - 2019 (1969) FX - Eucalyptus Oil MH - Eucalyptus Oil UI - D000078122 MN - D10.627.700.33 MN - D20.215.784.750.33 MS - An oily liquid that is extracted from the leaves of EUCALYPTUS trees. HN - 2019 FX - Eucalyptol MH - Euthanasia, Involuntary UI - D000078625 MN - I1.198.240.250 MS - The act or practice of killing or withholding life-sustaining treatment from a person with a medical condition, especially DISABLED PERSONS, without INFORMED CONSENT, despite the MENTAL COMPETENCY of the person to give consent. It may be viewed as a mercy killing or for the good of society, when widespread practice is ideologically or politically sanctioned, as under NATIONAL SOCIALISM. AN - Nazi Euthanasia Program goes here; coordinate with NATIONAL SOCIALISM HN - 2019: use EUTHANASIA 1977-2018 MH - Ex-Smokers UI - D000078822 MN - M1.219 MS - Persons who do not smoke but that have a history of SMOKING. HN - 2019 FX - Non-Smokers FX - Smokers MH - Exenatide UI - D000077270 MN - D12.644.187 MN - D20.888.300 MN - D23.946.833.300 MS - A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide increases CYCLIC AMP levels in pancreatic acinar cells and acts as a GLUCAGON-LIKE PEPTIDE-1 RECEPTOR (GLP-1) agonist and incretin mimetic, enhancing insulin secretion in response to increased glucose levels; it also suppresses inappropriate glucagon secretion and slows gastric emptying. It is used an anti-diabetic and anti-obesity agent. HN - 2019 (1992) MH - Extracellular Polymeric Substance Matrix UI - D000077317 MN - A20.593.500 MN - G6.120.500 MS - Extracellular matrix formed by secreted polymeric organic compounds by microorganisms. This secreted compound is mostly polysaccharides but may include proteins, lipids, and nucleic acids. The matrix facilitates attachment of microbes to form various BIOFILM communities. HN - 2019 MH - Facilities and Services Utilization UI - D000078336 MN - E5.318.740.388 MN - H1.548.832.625 MN - N4.452.289 MN - N5.715.360.750.344 MN - N6.850.520.830.375 MS - Extent of use of facilities or services. It includes overuse and underuse. HN - 2019 MH - Famciclovir UI - D000077595 MN - D3.633.100.759.138.703 MS - An aminopurine derivative and prodrug of penciclovir which is a competitive inhibitor of herpes simplex 2 DNA polymerase. It is used to treat HERPES SIMPLEX VIRUS INFECTIONS. HN - 2019 (1989) MH - Family Separation UI - D000077642 MN - F1.829.263.387 MN - I1.880.853.150.446 MS - Geographic separation of members of a family. HN - 2019 MH - Felbamate UI - D000078328 MN - D2.33.455.706.388 MN - D2.241.81.251.583.366 MS - A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY. HN - 2019 (1986) MH - Ferric Oxide, Saccharated UI - D000077605 MN - D1.490.100.150 MN - D2.241.81.844.300.500 MN - D2.241.511.902.300.500 MN - D2.691.550.100.250 MN - D9.811.295.500 MS - A glucaric acid-iron conjugate that is used in the treatment of IRON-DEFICIENCY ANEMIA, including in patients with chronic kidney disease, when oral iron therapy is ineffective or impractical. HN - 2019 (1974) MH - Fidaxomicin UI - D000077732 MN - D2.540.505.225 MN - D2.540.576.500.994 MN - D4.345.674.500.500 MS - A narrow-spectrum macrolide antibacterial agent that is used in the treatment of diarrhea associated with CLOSTRIDIUM DIFFICILE INFECTION. HN - 2019 (1975) MH - Fish Proteins, Dietary UI - D000078504 MN - D12.776.256.472.250 MN - D12.776.325.250 MN - G7.203.300.428.472.250 MN - G7.203.300.600.625.250 MN - G7.203.300.600.875.550 MN - J2.500.428.472.250 MN - J2.500.600.625.250 MN - J2.500.600.875.550 MS - Dietary protein from FISH. HN - 2019 MH - Flacourtia UI - D000076623 MN - B1.650.940.800.575.912.250.859.797.875.450 MS - A genus of flowering plants in the family SALICACEAE, order MALPHIGIALES. An example is the willow, also known as salix or saules (French). HN - 2019 MH - Flexural Strength UI - D000077298 MN - G1.374.604 MS - The maximum MECHANICAL STRESS that a heterogeneous material, subject to a bending load or flexure, can withstand before fracturing. HN - 2019 FX - Materials Testing MH - Fluvastatin UI - D000077340 MN - D3.633.100.473.305 MN - D10.251.450.300 MS - An indole-heptanoic acid derivative that inhibits HMG COA REDUCTASE and is used to treat HYPERCHOLESTEROLEMIA. In contrast to other statins, it does not appear to interact with other drugs that inhibit CYP3A4. HN - 2019 (1990) MH - Focused Assessment with Sonography of Trauma UI - D000077564 MN - E1.370.350.850.423 MS - Rapid bedside ultrasound examination performed by medical personnel (surgeons, emergency physicians, paramedics and others), as a screening test for blood around the heart (PERICARDIAL EFFUSION) or abdominal organs (HEMOPERITONEUM) after trauma. HN - 2019 MH - Fomepizole UI - D000077604 MN - D3.383.129.539.344 MS - A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL. HN - 2019 (1975) MH - Fondaparinux UI - D000077425 MN - D9.698.629.429 MS - Synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. HN - 2019 (2001) MH - Forensic Psychology UI - D000077283 MN - F4.96.628.49 MN - I1.198.780.960 MS - A specialty in professional psychology characterized by activities primarily intended to provide professional psychological expertise within the judicial and legal systems. HN - 2019 MH - Forms as Topic UI - D000078763 MN - L1.399.250.372 MS - Works about documents used for acquiring particular information or for presenting particular information in a prescribed sequence and format, often with blank spaces or lines or other methods to prompt for insertion of the requested information. AN - do not confuse with the Publication Type FORM HN - 2019; use Records as Topic 2008-2018 MH - Formularies, Dental UI - D000078984 MN - V2.480.375 MS - Works on or about reference lists of descriptions and uses of drugs related to oral medicine and dentistry. AN - This heading is used as a Publication Type. Works on Dental Formularies as a subject are indexed under the main heading FORMULARIES, DENTAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Formularies, Hospital UI - D000078929 MN - V2.480.750 MS - Formulary concerned with PHARMACEUTICAL PREPARATIONS prescribed in hospitals. AN - This heading is used as a Publication Type. Works on Hospital Formularies as a subject are indexed under the main heading FORMULARIES, HOSPITAL AS TOPIC. INDEXER: Do not use HN - 2019 MH - Formulary, Homeopathic UI - D000078928 MN - V2.480.775 MS - Work about Formulary concerned with HOMEOPATHIC REMEDIES. AN - This heading is used as a Publication Type. Works on Homeopathic Formularies as a subject are indexed under the main heading FORMULARIES, HOMEOPATHIC AS TOPIC. INDEXER: Do not use HN - 2019 MH - Fruit Proteins UI - D000078562 MN - D12.776.256.356 MN - D12.776.765.354 MN - G7.203.300.428.920.113 MN - J2.500.428.920.125 MS - Proteins found in FRUIT. HN - 2019 MH - Fulvestrant UI - D000077267 MN - D4.210.500.365.415.248.660 MN - D6.472.334.851.437.500.500 MS - An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer. HN - 2019 (1991) MH - Gabapentin UI - D000077206 MN - D2.92.521 MN - D2.241.81.114.500.350.300 MN - D2.241.223.268.469 MN - D2.455.426.392.368.367.218.500 MN - D12.125.190.350.225 MS - A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME. HN - 2019 (1984) MH - Gait Analysis UI - D000077107 MN - E1.370.600.250.250 MN - N1.400.545.750.500 MS - Determination of the level of functional limitation that may be due to pathology, and evaluating rehabilitative intervention of the way in which the body moves from one point to another. Most often, this is done by walking. HN - 2019 MH - Gastric Artery UI - D000077426 MN - A7.15.114.365 MS - Any of several branches of the SPLENIC ARTERY distributed to the greater curvature of the stomach. HN - 2019 MH - GATA2 Deficiency UI - D000077428 MN - C16.320.314 MS - A rare disorder of the immune system with wide-ranging effects which include GATA2 Transcription Factor dysfunction, immunodeficiency, myelodysplastic syndrome (ineffective blood cell production), lung disease, and problems of the vascular and lymphatic system. HN - 2019 MH - Gatifloxacin UI - D000077734 MN - D3.633.100.810.835.322.316 MS - A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS. HN - 2019 (1992) MH - Gefitinib UI - D000077156 MN - D3.633.100.786.469 MS - A selective tyrosine kinase inhibitor for the EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) that is used for the treatment of locally advanced or metastatic NON-SMALL CELL LUNG CANCER. HN - 2019 (2001) MH - Gemifloxacin UI - D000077735 MN - D3.633.100.612.250 MN - D3.633.100.810.835.322.322 MS - A naphthyridine and fluoroquinolone derivative antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used for the treatment of community-acquired pneumonia and acute bacterial infections associated with chronic bronchitis. HN - 2019 (1997) MH - Genetic Profile UI - D000076610 MN - G5.346.500 MS - A set of characteristics unique to the DNA of an individual organism or population obtained by analyzing small samples of biological material such as body tissues or fluids, used especially in the context of predicting susceptibility to a particular disease. For example, some populations have identifiable genetic profiles which put them at higher risk for cancer. Distinguish from GENETIC BACKGROUND and GENETIC VARIATION. HN - 2019 MH - Gestational Weight Gain UI - D000078064 MN - C23.888.144.243.926.500 MN - G7.345.249.314.120.200.926.500 MN - G8.686.330 MS - Increase in body weight of the mother during the course of her PREGNANCY. HN - 2019 MH - Glymphatic System UI - D000077502 MN - A7.521 MN - A8.186.211.150 MN - A15.382.520.75 MS - A vascular waste clearance system in the brain analogous to the lymphatic system that facilitates transporting of solutes and waste products from CEREBROSPINAL FLUID (CSF) and brain INTERSTITIAL FLUID (ISF). CSF from the SUBARACHNOID SPACE enters the brain periarterial spaces, into the interstitium via channels (e.g., AQUAPORIN 4 PROTEIN) on astrocytic endfeet and exchanges with brain ISF before perivenous drainage of solutes and waste. HN - 2019 MH - Golgi Matrix Proteins UI - D000077614 MN - D12.776.407 MS - Proteins on the cytoplasmic side of the GOLGI APPARATUS cisternae that tether the cisternae to each other or to the transport vesicles of the TRANS-GOLGI NETWORK to maintain the Golgi structure and function. HN - 2019 MH - GRADE Approach UI - D000077002 MN - N5.715.360.575.575.399.375 MS - A common, sensible, structured and transparent approach to grading quality (or certainty) of evidence and strength of recommendations developed by the Grading of Recommendations Assessment, Development and Evaluation (short GRADE) working group. HN - 2019 MH - Grain Proteins UI - D000078522 MN - D12.776.256.395 MN - D12.776.765.433 MN - G7.203.300.428.920.225 MN - J2.500.428.920.250 MS - Dietary protein from EDIBLE GRAINS HN - 2019 MH - Granulins UI - D000077155 MN - D6.472.699.682.500 MN - D12.644.276.917.500 MN - D12.776.467.917.500 MN - D23.529.917.500 MS - Small, cysteine-rich peptides generated by the proteolytic cleavage of progranulin. Granulin peptides are each composed of a granulin-motif, while paragranulin is composed of a half granulin motif. The mammalian granulins are named granulin 1-7 for their sequence order in the progranulin propeptide, and are alternately named granulin G, F, B, A, C, D, and E; or epithelin 7, 6, 2, 1, 3, 4, and 5, i.e. granulin 1 aka granulin G aka epithelin 7, etc. AN - do not confuse with the viral protein GRANULIN MATRIX PROTEINS see OCCLUSION BODY MATRIX PROTEINS HN - 2019 MH - Gray Literature UI - D000076889 MN - L1.178.682.550 MS - Works that include publications such as reports, theses, conference papers, translations and limited circulation government documents which are not normally available through commercial publication sources. (LCSH) HN - 2019 MH - Gun Violence UI - D000078402 MN - I1.198.240.856.519 MN - I1.880.735.900.632 MS - Violence using any type of firearm. HN - 2019 MH - Harmala Alkaloids UI - D000077290 MN - D3.633.100.473.402.222 MS - Structurally-related ALKALOIDS derived from the seeds of PEGANUM HARMALA and other plant sources. They are associated with various pharmacologic and therapeutic effects. HN - 2019 MH - Healthcare-Associated Pneumonia UI - D000077299 MN - C1.539.248.250 MN - C8.381.677.300 MN - C8.730.610.300 MN - C23.550.291.875.500.500 MS - Infection of the lung often accompanied by inflammation that is acquired through an interaction within a healthcare institution often through a therapeutic experience (e.g., use of catheters or ventilators). HN - 2019 MH - Histone Methyltransferases UI - D000076983 MN - D8.811.913.555.500.800.200 MS - Enzymes that catalyze the transfer of methyl groups to LYSINE or ARGININE residues of HISTONES, especially histone H3 and histone H4 proteins. They play a critical role in EPIGENETIC PROCESSES. HN - 2019 (1972); for HISTONE-ARGININE N-METHYLTRANSFERASE use PROTEIN-ARGININE N-METHYLTRANSFERASES 2010-2018 MH - History of Pharmacy UI - D000077406 MN - K1.400.456 MS - Study of the origins and development of the field of PHARMACY. HN - 2019 MH - Homoharringtonine UI - D000077863 MN - D3.132.420.500 MN - D3.633.100.79.533.500 MN - D3.633.400.624.500 MS - Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC. HN - 2019 (1972) MH - Hospitals, Rehabilitation UI - D000077773 MN - N2.278.421.556.193 MN - N2.421.784.411 MS - Free standing rehabilitation hospitals and rehabilitation units in acute care hospitals. They provide an intensive inpatient rehabilitation program. HN - 2019 MH - Host Microbial Interactions UI - D000076662 MN - G6.373 MN - G16.527 MS - Interactions between a host and microbe or microbiota. HN - 2019 MH - Ibandronic Acid UI - D000077557 MN - D2.705.429.500.844 MS - Aminobisphosphonate that is a potent inhibitor of BONE RESORPTION. It is used in the treatment of HYPERCALCEMIA associated with malignancy, for the prevention of fracture and bone complications in patients with breast cancer and bone metastases, and for the treatment and prevention of POSTMENOPAUSAL OSTEOPOROSIS. HN - 2019 (1992) MH - Icodextrin UI - D000077607 MN - D5.750.78.562.622 MN - D9.698.365.399 MS - A glucan that is structurally related to maltodextrin, with more than 85% of its molecules having molecular weights between 1640 and 45 000 Daltons (Da), and a weight-average molecular weight of about 20 000 Da; it is used in dialysis fluids as an alternative to glucose-based solutions, and to reduce adhesions after gynecological or abdominal surgery. It has also been used as a vehicle for drugs given via the peritoneal cavity. HN - 2019 (1997) MH - Imiquimod UI - D000077271 MN - D3.633.100.810.50.545 MS - A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS. HN - 2019 (1988) MH - Immunoglobulin G4-Related Disease UI - D000077733 MN - C20.111.572 MS - A spectrum of systemic autoimmune diseases in which IMMUNOGLOBULIN G4 plays a pathophysiologic role. It can affect multiple organs in highly variable presentations, characterized by inflammatory lesions composed of IgG4-positive PLASMA CELLS, further infiltrated by T helper cells (T-LYMPHOCYTES, HELPER-INDUCER) when linked to progressive FIBROSIS and eventual organ damage. HN - 2019 MH - Implementation Science UI - D000077626 MN - L1.143.320.400 MS - The study of methods to promote the adoption and integration of evidence-based practices, interventions and policies into routine health care and public health settings. HN - 2019 MH - Insulin Secretion UI - D000078790 MN - G3.442 MN - G7.475 MS - Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels. HN - 2019 MH - Insurance, Vision UI - D000077776 MN - N3.219.521.576.343.750 MS - Insurance providing coverage for vision care. HN - 2019 MH - Interferon alpha-2 UI - D000077190 MN - D12.644.276.374.440.890.250.500 MN - D12.776.467.374.440.890.250.500 MN - D23.529.374.440.890.250.500 MS - Alpha interferons encoded by the human IFNA2 gene. Recombinant forms are used in the treatment of CHRONIC HEPATITIS B; CHRONIC HEPATITIS C; KAPOSI SARCOMA; MELANOMA; and HAIRY CELL LEUKEMIA. HN - 2019; use INTERFERON-ALPHA 2012-2018 MH - International Health Regulations UI - D000076702 MN - I1.655.500.608.400.468 MN - N3.706.615.473.250 MS - Regulations to prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks. (www.who.int/features/qa/39/en) HN - 2019 MH - Internet Access UI - D000077230 MN - L1.143.539 MN - L1.224.230.110.500.625 MS - Ability to connect to the INTERNET and access services available there. HN - 2019; INTERNET (1999-2018) MH - Irbesartan UI - D000077405 MN - D2.455.426.559.389.185.413 MN - D2.455.426.779.431 MN - D3.383.129.617.351 MN - D4.711.431 MS - A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease. HN - 2019 (1993) MH - Irinotecan UI - D000077146 MN - D3.132.151.425 MS - A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS. HN - 2019 (1987) MH - Ivabradine UI - D000077550 MN - D3.633.100.79.801 MS - A benzazepine derivative and selective HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS inhibitor that lowers the heart rate. It is used in the treatment of CHRONIC STABLE ANGINA in patients unable to take BETA-ADRENERGIC BLOCKERS, and in the treatment of HEART FAILURE. HN - 2019 (1994) MH - Lacosamide UI - D000078334 MN - D2.65.64.416 MN - D2.241.81.18.110.432 MS - An acetamide derivative that acts as a blocker of VOLTAGE-GATED SODIUM CHANNELS. It is used as an anticonvulsant, for adjunctive or monotherapy, in the treatment of PARTIAL SEIZURES. HN - 2019 (2000) MH - Lamotrigine UI - D000077213 MN - D3.383.931.480 MS - A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER. HN - 2019 (1986) MH - Lapatinib UI - D000077341 MN - D3.633.100.786.516 MS - A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2. HN - 2019 (2004) MH - Latanoprost UI - D000077338 MN - D10.251.355.255.550.775.500.587 MN - D23.469.50.175.725.775.500.587 MN - D23.469.700.670.587 MS - A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA. HN - 2019 (1992) MH - Latent Class Analysis UI - D000077272 MN - E5.318.740.250.338 MN - G17.35.625 MN - L1.224.50.687 MN - N5.715.360.750.200.375 MN - N6.850.520.830.250.338 MS - A statistical algorithm used to analyze clusters of observed variables by constructing categorical unobserved or latent segment based on weighted analysis and the average probabilities. Such latent classes are used to infer variables whose relationships are not directly observed. In biomedical research, it is often used to categorize data that allows the determination of symptom clusters. HN - 2019 MH - Leflunomide UI - D000077339 MN - D3.383.129.385.475 MS - An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS. HN - 2019 (1985) MH - Lenalidomide UI - D000077269 MN - D2.241.223.805.810.400 MN - D3.383.621.808.519 MN - D3.633.100.513.750.563 MS - A phthalimide and piperidone derivative that has immunomodulatory and antiangiogenic properties. It is used for the treatment of transfusion-dependent anemia in MYELODYSPLASTIC SYNDROMES, and for the treatment of MULTIPLE MYELOMA, and relapsed or refractory MANTLE CELL LYMPHOMA. HN - 2019 (2002) MH - Lenograstim UI - D000078224 MN - D12.644.276.374.410.240.350.750 MN - D12.776.395.240.200.750 MN - D12.776.467.374.410.240.350.750 MN - D23.529.374.410.240.350.750 MS - A recombinant granulocyte colony-stimulating factor that is used to treat or prevent NEUTROPENIA in patients receiving myelosuppressive cancer chemotherapy, for the preparation and collection of blood progenitor cells in PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; and in the treatment of severe congenital neutropenia. Component 1 and Component 2 differ by absence or presence of Neu5Ac in 2-6 linkage to GalNAc side chain. HN - 2019 (1993) MH - Letrozole UI - D000077289 MN - D2.626.300 MN - D3.383.129.799.638 MS - A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women. HN - 2019 (1991) MH - Leucanthemum UI - D000078062 MN - B1.650.940.800.575.912.250.100.503 MS - A genus of flowering plants in the family ASTERACEAE, mainly distributed in southern and central Europe, and on other continents as introduced species. Leucanthemum species include annuals and perennials grown for their daisy flowers, which are usually gleaming white with yellow centers. HN - 2019 MH - Levetiracetam UI - D000077287 MN - D2.65.64.432 MN - D2.241.81.18.110.463 MN - D3.383.773.812.362 MS - A pyrrolidinone and acetamide derivative that is used primarily for the treatment of SEIZURES and some movement disorders, and as a nootropic agent. HN - 2019 (1980) MH - Levobupivacaine UI - D000077554 MN - D2.65.199.239.500 MN - D2.92.146.113.239.500 MS - S-enantiomer of bupivacaine that is used as a local anesthetic and for regional nerve blocks, including EPIDURAL ANESTHESIA. HN - 2019 (2003) MH - Levomilnacipran UI - D000078862 MN - D2.455.426.392.368.533.725.500 MS - The (1S,2R)-isomer of milnacipran that is used for the treatment of MAJOR DEPRESSIVE DISORDER. HN - 2019; use MILNACIPRAN 2013-2018 MH - Lidocaine, Prilocaine Drug Combination UI - D000077442 MN - D2.65.199.92.500.500 MN - D2.65.199.750.500 MN - D2.92.146.113.92.500.500 MN - D2.92.146.113.750.500 MN - D26.310.454 MS - A topical local anesthetic preparation that is composed of a mixture of lidocaine and prilocaine. It is used to provide anesthesia during minor surgery and for the treatment of PREMATURE EJACULATION. HN - 2019 (1983) MH - Limonene UI - D000077222 MN - D2.455.426.392.368.367.379.437 MN - D2.455.849.575.625 MS - A naturally occurring class of MONOTERPENES which occur as a clear colourless liquid at room temperature. Limonene is the major component in the oil of oranges which has many uses, including as flavor and fragrance. It is recognized as safe in food by the Food and Drug Administration (FDA). HN - 2019(1969) MH - Lipoabdominoplasty UI - D000077845 MN - E2.218.42.500 MN - E2.570.500.62.937.500 MN - E4.62.937.500 MN - E4.680.25.500 MS - Aesthetic surgical treatment of the abdominal region using LIPOSUCTION associated with ABDOMINOPLASTY. HN - 2019 MH - Lipoglycopeptides UI - D000077427 MN - D9.400.420.405 MN - D12.644.233.352 MN - D12.644.365.625 MS - Glycopeptides that have an additional lipophilic side chains. Several semisynthetic lipoglycopeptide antibiotics are derived from naturally occurring lipoglycopeptide and glycopeptide antibiotics. HN - 2019 MH - Lumefantrine UI - D000078102 MN - D2.455.426.559.847.389.650 MN - D4.615.389.650 MS - A fluorene derivative that is used in combination with ARTEMETHER for the treatment of MALARIA (see ARTEMETHER-LUMEFANTRINE COMBINATION). HN - 2019 (1996) MH - Lycopene UI - D000077276 MN - D2.455.326.271.665.202.216 MN - D2.455.426.392.368.367.379.249.213 MN - D2.455.849.131.216 MN - D23.767.261.375 MS - A carotenoid and red pigment produced by tomatoes, other red fruits and vegetables, and photosynthetic algae. It is a key intermediate in the biosynthesis of other carotenoids, and has antioxidant, anti-carcinogenic, radioprotective, and anti-inflammatory properties. HN - 2019 (1978) MH - Maesa UI - D000076643 MN - B1.650.940.800.575.912.250.341.984.718 MS - A genus of flowering plants in the family PRIMULACEAE, order ERICALES. HN - 2019 MH - Malpighiales UI - D000076622 MN - B1.650.940.800.575.912.250.859.797 MS - Order of flowering plants which includes many tropical species. Well-characterized members include SALICACEAE (willow family), VIOLACEAE (violet family), PASSIFLORACEAE (passion-flower family), EUPHORBIACEAE (spurge or croton family), RHIZOPHORACEAE (mangrove family), and ERYTHROXYLACEAE (coca family). HN - 2019 MH - Malvales UI - D000077142 MN - B1.650.940.800.575.912.250.859.821 MS - An order of mostly woody plants in the superorder ROSANAE. Members of the MALVALES grow in various habitats around the world. HN - 2019 MH - Manuscript, Medical UI - D000077862 MN - V2.630.250 MS - Medical works prepared by hand including handwritten or typescript drafts of pre-publication papers or works not otherwise reproduced in multiple copies. AN - This heading is used as a Publication Type. Medical Manuscripts as a subject are indexed under the main heading MANUSCRIPTS, MEDICAL AS TOPIC. INDEXER: Do not use. CATALOGER: Use for historical material only HN - 2019 MH - Maraviroc UI - D000077592 MN - D2.455.426.392.368.367.726 MN - D3.383.129.799.682 MS - A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for membrane fusion and cellular entry. HN - 2019 (2005) MH - Meat Proteins UI - D000078502 MN - D12.776.256.472 MN - G7.203.300.428.472 MN - G7.203.300.600.625 MN - J2.500.428.472 MN - J2.500.600.625 MS - Dietary proteins from MEAT. HN - 2019 MH - Medical Countermeasures UI - D000078642 MN - N6.230.100.195 MN - N6.850.780.588 MS - Regulated products (biologics, drugs, devices) that may be used in the event of a potential public health emergency stemming from a terrorist attack with a biological, chemical, or radiological/nuclear material, or a naturally occurring emerging disease. HN - 2019 MH - Meglumine Antimoniate UI - D000077485 MN - D2.33.800.813.550.800 MN - D9.67.342.600.800 MN - D9.853.813.550.800 MS - ANTIMONY salt of meglumine that is used in the treatment of LEISHMANIASIS. HN - 2019 (1972) MH - Meloxicam UI - D000077239 MN - D2.886.665.275 MN - D2.886.675.448 MN - D3.383.129.708.448 MN - D3.383.855.275 MS - A benzothiazine and thiazole derivative that acts as a NSAID and cyclooxygenase-2 (COX-2) inhibitor. It is used in the treatment of RHEUMATOID ARTHRITIS; OSTEOARTHRITIS; and ANKYLOSING SPONDYLITIS. HN - 2019 (1990) MH - Mentalization UI - D000076563 MN - F2.463.467 MS - The mental process by which an individual implicitly and explicitly interprets the actions of self and others as meaningful on the basis of intentional mental states such as personal desires, needs, feelings, beliefs, and reasons. HN - 2019 MH - Meropenem UI - D000077731 MN - D2.65.589.99.124.300.750 MN - D3.633.100.300.124.300.750 MS - A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients. HN - 2019 (1989) MH - Methantheline UI - D000077771 MN - D2.92.877.562 MN - D2.675.276.569 MS - A quaternary ammonium compound that acts as an antimuscarinic agent. It has been used in the treatment of PEPTIC ULCER, in gastrointestinal disorders associated with smooth muscle spasm, and in the management of urinary incontinence, and may also be used for the treatment of HYPERHIDROSIS. HN - 2019 (1963) MH - Methylprednisolone Acetate UI - D000077555 MN - D4.210.500.745.432.769.795.539.250 MS - Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY. HN - 2019 (1969) MH - Micafungin UI - D000077551 MN - D10.477.625 MN - D12.644.365.750 MN - D12.644.641.311.750 MS - A cyclic lipo-hexapeptide echinocandin antifungal agent that is used for the treatment and prevention of CANDIDIASIS. HN - 2019 (1999) MH - Midkine UI - D000078792 MN - D12.644.276.854 MN - D12.776.467.848 MN - D23.529.831 MS - A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury. HN - 2019 (1991) MH - Milnacipran UI - D000078764 MN - D2.455.426.392.368.533.725 MS - A cyclopropanecarboxamide serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of FIBROMYALGIA. HN - 2019 (1986) MH - Mirtazapine UI - D000078785 MN - D3.633.300.240.588 MS - A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders. HN - 2019 (1982) MH - Mivacurium UI - D000077590 MN - D3.633.100.531.430 MS - An isoquinoline derivative that is used as a short-acting non-depolarizing agent. HN - 2019 (1986) MH - Modafinil UI - D000077408 MN - D2.455.426.559.389.115.550 MS - A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS. HN - 2019 (1986) MH - Moxifloxacin UI - D000077266 MN - D3.633.100.810.835.322.327 MS - A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent. HN - 2019 (1997) MH - Myopericytoma UI - D000077777 MN - C4.557.450.565.545 MN - C4.557.645.380.500 MN - C17.300.680.770 MS - Rare myofibroma-like perivascular soft tissue tumor, usually benign, characterized by concentric perivascular proliferation. HN - 2019 MH - Myrsine UI - D000076644 MN - B1.650.940.800.575.912.250.341.984.746 MS - A genus of flowering plants in the family PRIMULACEAE, found worldwide but primarily in tropical and subtropical regions. HN - 2019(2003); use MYRSINACEAE 2003-2017 BX - Rapanea MH - Myrtales UI - D000077148 MN - B1.650.940.800.575.912.250.859.833 MS - Order of flowering plants distributed throughout the tropics and warmer regions of the world. The majority of these species belong to two families, Melastomataceae and Myrtaceae. Myrtales includes many trees (notably Eucalyptus), shrubs, such as the classic myrtle, several food, spices, and ornamental plants. HN - 2019 MH - Nabumetone UI - D000077430 MN - D2.522.296.650 MS - A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS. HN - 2019 (1982) MH - Nandrolone Decanoate UI - D000077603 MN - D4.210.500.365.415.638.500 MN - D6.472.334.851.968.976.500 MS - Decanoic acid ester of nandrolone that is used as an anabolic agent to prevent or treat WASTING SYNDROME associated with severe chronic illness or HIV infection (HIV WASTING SYNDROME). It may also be used in the treatment of POSTMENOPAUSAL OSTEOPOROSIS. HN - 2019 (1971) MH - Nasopharyngeal Carcinoma UI - D000077274 MN - C4.557.470.200.623 MN - C4.588.443.665.710.650.500 MN - C7.550.350.650.500 MN - C7.550.745.650.500 MN - C9.647.710.650.500 MN - C9.775.350.650.500 MN - C9.775.549.650.500 MS - A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. AN - coordinate IM with NASOPHARYNGEAL NEOPLASMS (IM) HN - 2019 (2010) MH - Nateglinide UI - D000077715 MN - D2.455.426.392.368.367.745 MN - D12.125.72.50.685.448 MS - A phenylalanine and cyclohexane derivative that acts as a hypoglycemic agent by stimulating the release of insulin from the pancreas. It is used in the treatment of TYPE 2 DIABETES. HN - 2019 (1989) MH - Natural Disasters UI - D000077587 MN - N6.230.100.230 MS - Disasters linked to natural hazards including widespread fires, floods, storms, earthquakes and drought.These events may result in significant damage and loss of lives. HN - 2019 MH - Negative Results UI - D000076723 MN - E5.318.308.544 MN - L1.399.250.780 MN - N5.715.360.300.520 MN - N6.850.520.308.544 MS - Subject matter related to research studies in which the data do not demonstrate any clear evidence of effect, especially if an effect was expected. HN - 2019 MH - Neonatal Brachial Plexus Palsy UI - D000076984 MN - C10.668.829.100.750 MN - C16.614.131.294 MN - C26.141.294 MS - Perinatal nerve injury involving the BRACHIAL PLEXUS involving a weak or paralyzed upper extremity. HN - 2019 MH - Neuroglobin UI - D000078787 MN - D12.776.422.316.970 MN - D12.776.631.635 MS - A vertebrate globin that is expressed predominantly in the brain where it is involved in oxygen transport. It protects neurons from APOPTOSIS during OXIDATIVE STRESS. HN - 2019 (2000) MH - Neurolymphomatosis UI - D000077162 MN - C10.551.568 MS - Infiltration of the nervous system by malignant lymphoma cells. HN - 2019(1975); use Marek Disease 1975-2018 MH - Niemann-Pick C1 Protein UI - D000077296 MN - D12.776.157.530.594 MN - D12.776.543.585.594 MN - D12.776.543.750.58.250 MN - D12.776.543.750.830.235 MN - D12.776.624.776.633.250 MS - A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE. HN - 2019 MH - Nivolumab UI - D000077594 MN - D12.776.124.486.485.114.224.60.829 MN - D12.776.124.790.651.114.224.60.829 MN - D12.776.377.715.548.114.224.200.829 MS - A genetically engineered, fully humanized immunoglobulin G4 monoclonal antibody that binds to the PD-1 RECEPTOR, activating an immune response to tumor cells. It is used as monotherapy or in combination with IPILIMUMAB for the treatment of advanced malignant MELANOMA. It is also used in the treatment of advanced or recurring NON-SMALL CELL LUNG CANCER; RENAL CELL CARCINOMA; and HODGKIN'S LYMPHOMA. HN - 2019 (2010) MH - Non-Smokers UI - D000078405 MN - M1.482 MS - Persons without a history of SMOKING. HN - 2019 FX - Ex-Smokers FX - Smokers MH - Norethindrone Acetate UI - D000077563 MN - D4.210.500.668.651.693.651.500 MS - Acetate ester of norethindrone that is used as a long-term contraceptive. HN - 2019 (1980) MH - Nuclear Receptor Interacting Protein 1 UI - D000078723 MN - D12.644.360.24.315 MN - D12.776.157.57.86 MN - D12.776.476.24.396 MN - D12.776.660.688 MS - A nuclear protein, characterized by multiple LXXLL motifs, that modulates activation of gene transcription by STEROID RECEPTORS, and transcriptional repression by NUCLEAR HORMONE RECEPTORS. It positively regulates gene expression of CIRCADIAN CLOCK PROTEINS AND PEPTIDES, including ARNTL TRANSCRIPTION FACTORS and CRYPTOCHROMES. HN - 2019 (1995) MH - Nurses Improving Care for Health System Elders UI - D000076562 MN - N5.300.559 MS - Nonprofit programs designed to address the complex needs of older adults and improve outcomes. They provide the principles, education and tools to support healthcare systems in transforming and achieving patient centered care. AN - CATALOGER: use NAF entry HN - 2019 MH - Nut Proteins UI - D000078563 MN - D12.776.256.356.500 MN - D12.776.765.354.500 MN - G7.203.300.428.920.450 MN - J2.500.428.920.375 MS - Proteins from NUTS. HN - 2019 MH - Nutrients UI - D000078622 MN - D27.505.696.377.683 MN - G7.203.300.681 MN - J2.500.681 MS - Various components of food that are required for nourishment. HN - 2019; use FOOD 2007-2018 MH - O-(Chloroacetylcarbamoyl)fumagillol UI - D000077609 MN - D2.455.426.392.368.367.763 MN - D2.455.849.765.597 MS - Semisynthetic analog of fumagillin (a cyclohexane-sesquiterpene antibiotic isolated from ASPERGILLUS FUMIGATUS) that inhibits angiogenesis. HN - 2019 (1991) MH - Observational Study, Veterinary UI - D000078323 MN - V3.175.750 MS - A work that reports on the results of a clinical study in which animal subjects may receive diagnostic, therapeutic, or other types of interventions, where the investigator does not assign participants to specific interventions. AN - this heading is used as a Publication Type; for original report of the conduct or results of a specific veterinary observational study HN - 2019 MH - Occlusion Body Matrix Proteins UI - D000077183 MN - D12.776.964.970.650 MS - Proteins that assemble into a crystalline polyhedral or ovicylindrical shape around insect viruses, including BACULOVIRIDAE and CYPOVIRUS. AN - note entry term GRANULIN MATRIX PROTEINS: do not confuse with GRANULINS HN - 2019; for GRANULIN MATRIX PROTEINS use VIRAL MATRIX PROTEINS 1988-2018 MH - Olanzapine UI - D000077152 MN - D3.633.100.79.80.738 MS - A benzodiazepine derivative that binds SEROTONIN RECEPTORS; MUSCARINIC RECEPTORS; HISTAMINE H1 RECEPTORS; ADRENERGIC ALPHA-1 RECEPTORS; and DOPAMINE RECEPTORS. It is an antipsychotic agent used in the treatment of SCIZOPHRENIA; BIPOLAR DISORDER; and MAJOR DEPRESSIVE DISORDER; it may also reduce nausea and vomiting in patients undergoing chemotherapy. HN - 2019 (1992) MH - Online Social Networking UI - D000077253 MN - L1.143.910.250 MS - Connectivity facilitated by computer-based communications among persons with family, work, or other common interests. HN - 2019 MH - Orlistat UI - D000077403 MN - D2.540.529 MS - A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity. HN - 2019 (1988) MH - Orthodontic Appliances, Fixed UI - D000077744 MN - E6.658.453.255 MS - ORTHODONTIC APPLIANCES attached to the teeth by adhesive material which cannot be removed from the mouth by the patient. These devices apply force to the teeth and supporting structures, thereby producing changes which control their growth and development. HN - 2019 MH - Oxaliplatin UI - D000077150 MN - D2.691.214.500 MS - An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS. HN - 2019 (1981) MH - Oxaprozin UI - D000077431 MN - D2.241.81.751.634 MN - D3.383.129.462.590 MS - An oxazole-propionic acid derivative, cyclooxygenase inhibitor, and non-steroidal anti-inflammatory drug that is used in the treatment of pain and inflammation associated with of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; and ARTHRITIS, JUVENILE. HN - 2019 (1975) MH - Oxcarbazepine UI - D000078330 MN - D3.633.300.240.127.500 MS - A carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4. HN - 2019 (1982) MH - Oxindoles UI - D000078183 MN - D3.132.436.511 MN - D3.633.100.473.402.528 MS - Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl and a carbonyl at the pyrrole ring typically at the 2-position. HN - 2019 MH - Palonosetron UI - D000077924 MN - D3.605.687.319 MN - D3.633.100.531.629 MS - Isoquinoline and quinuclidine derivative that acts as a 5-HT3 RECEPTOR antagonist. It is used in the prevention of nausea and vomiting induced by cytotoxic chemotherapy, and for the prevention of post-operative nausea and vomiting. HN - 2019 (1993) MH - Pamidronate UI - D000077268 MN - D2.705.429.500.858 MS - An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies. HN - 2019 (1979) MH - Pancreatic Intraductal Neoplasms UI - D000077779 MN - C4.557.470.615.665 MN - C4.588.274.761.875 MN - C4.588.322.475.875 MN - C6.301.761.875 MN - C6.689.667.812 MN - C19.344.421.875 MS - EPITHELIAL NEOPLASMS with pancreatic ductal differentiation that arises from the EXOCRINE PANCREAS and grows mostly within the PANCREATIC DUCTS. They are characterized by the presence of intraductal masses with mostly papillary growth pattern. Overt production of MUCIN within the pancreatic duct is associated with pancreatic intraductal papillary-mucinous neoplasm but not intraductal tubulopapillary neoplasm. HN - 2019 MH - Panitumumab UI - D000077544 MN - D12.776.124.486.485.114.224.60.864 MN - D12.776.124.790.651.114.224.60.864 MN - D12.776.377.715.548.114.224.200.864 MS - Recombinant human monoclonal antibody that binds to and inhibits the function of the EPIDERMAL GROWTH FACTOR RECEPTOR. It is used in the treatment of EGFR-expressing metastatic colorectal cancer that expresses wild-type ras gene (see GENES, RAS). HN - 2019 (2005) MH - Panobinostat UI - D000077767 MN - D2.92.570.394.535 MN - D2.241.511.372.535 MN - D3.633.100.473.746 MS - An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA. HN - 2019 (2005) MH - Pantoprazole UI - D000077402 MN - D2.886.640.74.625 MN - D3.383.725.24.625 MN - D3.633.100.103.34.625 MS - 2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER. HN - 2019 (1990) MH - PC-3 Cells UI - D000078722 MN - A11.251.210.190.690 MN - A11.436.714 MS - An epithelial cell line initiated from a human bone metastasis of a grade IV prostatic ADENOCARCINOMA. AN - almost always NIM with no subheadings; check HUMAN; do not routinely add PROSTATIC NEOPLASMS or ADENOCARCINOMA HN - 2019 MH - Pea Proteins UI - D000078724 MN - D12.776.256.920.500 MN - D12.776.765.836.500 MN - G7.203.300.428.920.500 MN - J2.500.428.920.500 MS - Dietary proteins that are present in or isolated from the seeds of PISUM SATIVUM. HN - 2019 MH - Pharmacopoeia, Homeopathic UI - D000078930 MN - V2.695.750 MS - Authoritative resource describing the composition, properties, manufacture, and quality control of HOMEOPATHIC REMEDIES. AN - This heading is used as a Publication Type. Homeopathic Pharmacopoeias as a subject are indexed under the main heading PHARMACOPOEIAS, HOMEOPATHIC AS TOPIC. INDEXER: Do not use HN - 2019 MH - Physical Functional Performance UI - D000076604 MN - N1.400.545.750 HN - 2019 MH - Pinealectomy UI - D000076822 MN - E4.270.775 MS - Surgical removal of the PINEAL GLAND including resection of pineal tumor (PINEALOMA) and CYSTS. HN - 2019 FX - Pineal Gland FX - Pinealoma MH - Pioglitazone UI - D000077205 MN - D2.886.675.933.250 MN - D3.383.129.708.933.250 MS - A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS. HN - 2019 (1989) FX - Rosiglitazone MH - Piperacillin, Tazobactam Drug Combination UI - D000077725 MN - D2.65.589.99.750.687.750.500 MN - D2.65.589.99.750.750.50.650.500 MN - D2.886.108.750.687.750.500 MN - D2.886.108.750.750.50.650.500 MN - D2.886.590.841.500 MN - D3.633.100.300.750.687.750.500 MN - D3.633.100.300.750.750.50.650.500 MN - D26.310.625 MS - An antibiotic combination product of piperacillin and tazobactam, a penicillanic acid derivative with enhanced beta-lactamase inhibitory activity, that is used for the intravenous treatment of intra-abdominal, pelvic, and skin infections and for community-acquired pneumonia of moderate severity. It is also used for the treatment of PSEUDOMONAS AERUGINOSA INFECTIONS. HN - 2019 (1994) MH - Piperazine UI - D000077489 MN - D3.383.606.413 MS - An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces. AN - PIPERAZINES is also available HN - 2019 (1982) MH - Plastination UI - D000077780 MN - E2.792.400 MN - E5.760.400 MS - Preservation technique in which epoxy polymers are used to preserve tissue or an organ resulting in anatomically authentic dry specimens often used in teaching of anatomy. HN - 2019 MH - Polidocanol UI - D000077423 MN - D2.33.455.250.700.670 MN - D5.750.741.630 MN - D25.720.741.630 MN - J1.637.51.720.741.630 MS - An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12–14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS. HN - 2019 (1974) MH - Polyacetylene Polymer UI - D000078789 MN - D2.455.326.271.665.515 MN - D5.750.223 MN - D25.720.719 MN - J1.637.51.720.719 MS - A polyene polymer that consists of alternating single and double bonds. HN - 2019; use POLYACETYLENES 2007-2018 MH - Polylactic Acid-Polyglycolic Acid Copolymer UI - D000077182 MN - D2.241.511.459.450.500 MN - D5.750.728.780.500 MN - D25.720.728.780.500 MN - J1.637.51.720.728.780.500 MS - A co-polymer that consists of varying ratios of polylactic acid and polyglycolic acid. It is used as a matrix for drug delivery and for BONE REGENERATION. HN - 2019 (1984) MH - Population Health Management UI - D000076602 MN - N5.300.570 MS - Community engagement, facility management, and organization, access to care that is timely and affordable; the availability of effective services, and high-quality primary health care. (World Health Organization) HN - 2019 MH - Post-Lyme Disease Syndrome UI - D000077342 MN - C1.252.400.155.569.800 MN - C1.252.400.825.480.850 MN - C1.252.847.193.569.800 MS - A condition caused by long-lasting and ongoing infection with the spirochete Borrelia burgdorferi resulting in progressive inflammatory neurologic, neuromuscular, and dermatologic manifestations including ENCEPHALITIS; MYELITIS; acrodermatitis chronica atrophicans; and ARTHRITIS. HN - 2019 MH - Posttraumatic Growth, Psychological UI - D000078002 MN - F1.58.683 MN - F2.647 MS - Positive change experienced as a result of the struggle with a major life crisis or a traumatic event. HN - 2019 MH - Poultry Proteins UI - D000078503 MN - D12.776.256.472.500 MN - G7.203.300.428.472.500 MN - G7.203.300.600.625.500 MN - G7.203.300.600.750.750 MN - J2.500.428.472.500 MN - J2.500.600.625.500 MN - J2.500.600.750.750 MS - Dietary proteins from POULTRY. HN - 2019 MH - Pramipexole UI - D000077487 MN - D3.383.129.708.89.514 MN - D3.633.100.185.514 MS - A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME. HN - 2019 (1989) MH - Pregnane X Receptor UI - D000077297 MN - D12.776.826.750.75 MN - D12.776.930.778.175 MS - Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES. HN - 2019 (1998) MH - Preprint UI - D000076942 MN - V2.630.500 MS - Scientific manuscript made available prior to PEER REVIEW. AN - This heading is used as a Publication Type. Preprints as a subject are indexed under the main heading PREPRINTS AS TOPIC. INDEXER: Do not use HN - 2019 MH - Preprints as Topic UI - D000076682 MN - L1.178.682.733 MN - L1.737.736 MS - Works about scientific manuscripts made available prior to PEER REVIEW. AN - do not confuse with the Publication Type PREPRINT HN - 2019 MH - Prior Authorization UI - D000078482 MN - N3.219.521.576.343.944 MS - A decision by a health insurer or plan that a health care service, treatment plan, prescription drug or durable medical equipment is medically necessary. HN - 2019 MH - Procalcitonin UI - D000077740 MN - D6.472.699.666 MN - D12.644.548.744 MN - D12.776.811.555 MS - A peptide prohormone precursor of CALCITONIN. It is normally present at low levels in serum, but is released into the bloodstream, primarily from neuroendocrine cells in the lungs and intestines, in response to INFLAMMATION and BACTERIAL INFECTIONS. It is a diagnostic marker for BACTEREMIA. HN - 2019; use CALCITONIN 1981-2018 MH - Procedures and Techniques Utilization UI - D000078337 MN - E5.318.740.675 MN - H1.548.832.750 MN - N5.715.360.750.660 MN - N6.850.520.830.675 MS - Extent of use of procedures or techniques. It includes overuse and underuse. HN - 2019 MH - Proctectomy UI - D000078542 MN - E4.210.895 MS - Surgical resection of the RECTUM. HN - 2019 MH - Progranulins UI - D000077153 MN - D6.472.699.682 MN - D12.644.276.917 MN - D12.776.467.917 MN - D12.776.811.703 MN - D23.529.917 MS - A cysteine-rich, precursor glycoprotein, encoded by the granulin gene (GRN). It contains granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. HN - 2019 MH - Progression-Free Survival UI - D000077982 MN - E1.789.800.285 MN - E5.318.740.998.738 MN - N4.761.559.590.800.474 MN - N5.715.360.575.575.800.474 MN - N5.715.360.750.795.738 MN - N6.850.520.830.998.825 MS - Length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but the disease does not get worse. HN - 2019; use DISEASE-FREE SURVIVAL 1995-2018; for EVENT-FREE SURVIVAL use DISEASE-FREE SURVIVAL 1995-2018 BX - Event-Free Survival FX - Disease-Free Survival MH - Protein Carbamylation UI - D000077279 MN - G2.111.660.871.790.600.250 MN - G2.111.691.600.250 MN - G3.673.518 MN - G3.734.871.790.600.250 MN - G5.308.670.600.250 MN - G7.775.750.625 MS - Non-enzymatic addition of carbamoyl (-CONH2) on protein or amino acid functional groups from isocyanic acid or CARBAMOYL-PHOSPHATE. Carbamylation may induce a structural change that results in a functional loss and serves as a biomarker for protein aging and disease pathophysiology. HN - 2019 MH - Public Expenditures UI - D000077108 MN - N3.219.840 MS - Expenses of public funds incurred by government bodies: state, regional and local. HN - 2019 MH - Pyrolysis UI - D000077319 MN - G2.785 MS - High temperature decomposition without addition of extra air or oxygen. It yields syngas, bio-oil and bio-char. HN - 2019 MH - Quantitative Light-Induced Fluorescence UI - D000078704 MN - E5.196.712.516.600.543 MN - E6.342.626 MS - A FLUORESCENCE technique used in DENTISTRY for the analysis of mineral changes in DENTAL ENAMEL to detect early DENTAL CARIES, or for the evaluation other normal or pathological processes or lesions of the dental enamel. HN - 2019 MH - Quinapril UI - D000077583 MN - D3.633.100.531.820.250 MS - A tetrahydroisoquinoline derivative and ANGIOTENSIN CONVERTING ENZYME inhibitor that is used in the treatment of HYPERTENSION and HEART FAILURE. HN - 2019 (1984) MH - Race Factors UI - D000076782 MN - N5.715.350.463 MS - A constituent element or influence that could be used in studies for racial disparities as variables such as those related to risk factors and disease and or differential access to services. HN - 2019 FX - Continental Population Groups MH - Radiofrequency Ablation UI - D000078703 MN - E2.808.750 MN - E4.14.760 MS - Removal of tissue using heat generated from electrodes delivering an alternating electrical current in the frequency of RADIO WAVES. HN - 2019 MH - Radiofrequency Therapy UI - D000078702 MN - E2.808 MS - The use of RADIO WAVES to conduct therapeutic procedures. The specific frequency, dosage, and intensity used vary depending on the desired effects which include heating, electrical stimulation, or ablation of tissues. HN - 2019 MH - Ranunculales UI - D000076664 MN - B1.650.940.800.575.912.250.836 MS - An order of flowering plants also known as the buttercup family. HN - 2019 MH - Reboxetine UI - D000077593 MN - D3.383.533.640.682 MS - A morpholine derivative that is a selective and potent noradrenaline reuptake inhibitor; it is used in the treatment of DEPRESSIVE DISORDER. HN - 2019 (1992) MH - Receptor, Transforming Growth Factor-beta Type I UI - D000077293 MN - D8.811.913.696.620.682.700.789 MN - D12.776.543.750.705.852.720.500 MN - D12.776.543.750.750.400.820.750 MS - A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE II TGF-BETA RECEPTORS to bind TGF-BETA and regulate a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS. HN - 2019 (1994) MH - Receptor, Transforming Growth Factor-beta Type II UI - D000077294 MN - D8.811.913.696.620.682.700.795 MN - D12.776.543.750.705.852.720.750 MN - D12.776.543.750.750.400.820.875 MS - A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE I TGF-BETA RECEPTORS when bound to TGF-BETA. This receptor complex regulates a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS. HN - 2019 (1993) MH - Receptors, Chimeric Antigen UI - D000076962 MN - D12.776.543.750.655.500 MN - D12.776.543.750.705.816.824.150 MN - D12.776.826.387.500 MS - Synthetic cellular receptors that reprogram T-LYMPHOCYTES to selectively bind antigens. AN - for CAR-T Cell Therapy, coordinate with CHIMERIC ANTIGEN RECEPTOR THERAPY see IMMUNOTHERAPY, ADOPTIVE HN - 2019 FX - Immunotherapy, Adoptive MH - Regenerative Endodontics UI - D000078483 MN - E6.397.737 MN - H2.163.876.213.500 MS - A dental specialty concerned with biologically-based procedures designed to physiologically replace damaged tooth structures, including dentin and root structures, as well as cells of the pulp-dentin complex. HN - 2019 FX - Regenerative Medicine MH - Remifentanil UI - D000077208 MN - D2.241.81.751.756 MN - D3.383.621.828 MS - A piperidine-propionate derivative and opioid analgesic structurally related to FENTANYL. It functions as a short-acting MU OPIOID RECEPTOR agonist, and is used as an analgesic during induction or maintenance of general anesthesia, following surgery, during childbirth, and in mechanically ventilated patients under intensive care. HN - 2019 (1991) MH - Respect UI - D000078682 MN - F1.100.907 MS - A feeling of deep admiration for someone or something elicited by their abilities, qualities, or achievements and regard for the feelings, wishes, or rights of others. HN - 2019 MH - Resveratrol UI - D000077185 MN - D2.455.426.559.389.150.700.375 MN - D2.455.426.559.389.657.715.500 MN - D3.633.100.150.266.450.260.777.500 MS - A stilbene and non-flavonoid polyphenol produced by various plants including grapes and blueberries. It has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties. It also inhibits platelet aggregation and the activity of several DNA HELICASES in vitro. HN - 2019 (1989) MH - Retention in Care UI - D000076522 MN - E2.760.169.671 MN - N2.421.585.169.671 MS - Patient's regular engagement with medical care after initial entry into the system. HN - 2019 MH - Rickettsiales UI - D000076944 MN - B3.660.50.783 MS - Order in class ALPHAPROTEOBACTERIA that are endosymbionts in eukaryotic cells. High morbidity and mortality is frequently associated with Rickettsiales transmitted by insect vectors. HN - 2019 MH - Rifaximin UI - D000078262 MN - D3.633.400.811.850 MN - D4.345.295.750.850 MS - A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY. HN - 2019 (1983) MH - Rilmenidine UI - D000077769 MN - D3.383.129.462.778 MS - Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION. HN - 2019 (1981) MH - Rimonabant UI - D000077285 MN - D3.383.129.539.888 MN - D3.383.621.834 MS - A pyrazole and piperidine derivative that acts as a selective cannabinoid type-1 receptor (CB1 RECEPTOR) antagonist. It inhibits the proliferation and maturation of ADIPOCYTES, improves lipid and glucose metabolism, and regulates food intake and energy balance. It is used in the management of OBESITY. HN - 2019 (1994) MH - Ringer's Lactate UI - D000077325 MN - D26.776.498.500.500 MS - A crystalloid solution that contains SODIUM CHLORIDE; SODIUM LACTATE; POTASSIUM CHLORIDE; and CALCIUM CHLORIDE. It is used for FLUID THERAPY. HN - 2019 (1981) FX - Ringer's Solution MH - Ringer's Solution UI - D000077331 MN - D26.776.498.750 MS - An isotonic solution; the base contains SODIUM CHLORIDE; POTASSIUM CHLORIDE; and CALCIUM CHLORIDE. Other chemicals, such as SODIUM BICARBONATE or acetate salts may be added, as needed for pH buffering, or as an energy source. HN - 2019 (1977) FX - Ringer's Lactate MH - RNA, Mitochondrial UI - D000077278 MN - D13.444.735.580 MS - RNA molecules encoded by the MITOCHONDRIAL GENOME. HN - 2019 (1984) MH - Road Rage UI - D000077315 MN - F1.145.263.750 MN - F1.470.93.640.500 MN - I1.880.735.223.375 MN - I3.125.824 MS - Extreme anger generated from a traffic incident or accident that leads to an assault with a motor vehicle or other dangerous weapon by the operator or passenger(s) of one motor vehicle on the operator or passenger(s) of another motor vehicle. HN - 2019 MH - Rocuronium UI - D000077123 MN - D4.210.500.54.40.783 MS - An androstanol non-depolarizing neuromuscular blocking agent. It has a mono-quarternary structure and is a weaker nicotinic antagonist than PANCURONIUM. HN - 2019 (1989) MH - Ropivacaine UI - D000077212 MN - D2.65.199.825 MN - D2.92.146.113.825 MS - An anilide used as a long-acting local anesthetic. It has a differential blocking effect on sensory and motor neurons. HN - 2019 (1983) FX - Bupivacaine MH - Roscovitine UI - D000077546 MN - D3.633.100.759.776 MS - A purine derivative and competitive inhibitor of CYCLIN-DEPENDENT KINASES that has therapeutic potential as an antineoplastic and antiviral agent. HN - 2019 (1997) MH - Rosiglitazone UI - D000077154 MN - D2.886.675.933.500 MN - D3.383.129.708.933.500 MS - A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS. HN - 2019 (1994) FX - Pioglitazone MH - Sadness UI - D000078602 MN - F1.470.933 MS - Feeling or showing sorrow; the sense of being unhappy. It is related to DEPRESSION but is not synonymous. HN - 2019 MH - Saline Solution UI - D000077330 MN - D26.776.498.500.750 MS - A crystalloid solution that contains 9.0g of SODIUM CHLORIDE per liter of water. It has a variety of uses, including: as a CONTACT LENS SOLUTION, in OPHTHALMIC SOLUTIONS and NASAL LAVAGE, in wound irrigation, and for FLUID THERAPY. HN - 2019; use SODIUM CHLORIDE 1978-2018 MH - Salt Stress UI - D000077323 MN - G7.775.813 MS - The condition that results from ion toxicity due to ion imbalances (e.g., excessive Na+ and deficiency in Mg++). HN - 2019 MH - Saporins UI - D000076985 MN - D8.811.277.450.430.700.500.500 MN - D12.776.765.710.500.250 MS - Type 1 ribosome inactivating proteins derived from SAPONARIA OFFICINALIS that function through endohydrolysis of the N-glycosidic bond at single ADENOSINE residues of 28S RIBOSOMAL RNA. They are used as IMMUNOTOXINS. HN - 2019 (1985) FX - Saponins MH - Saxifragales UI - D000076607 MN - B1.650.940.800.575.912.250.890 MS - Order of dicotyledonous flowering plants consisting of 16 families, 112 genera, and nearly 2,500 species. HN - 2019 MH - Screen Time UI - D000077705 MN - I3.723 MS - Period of activities done in front of an electronic screen, such as watching TV, working on a computer, or playing video games. HN - 2019 MH - Secretagogues UI - D000078604 MN - D27.505.696.937 MS - Substances that stimulate the secretion of another substance. HN - 2019 MH - Self-Neglect UI - D000077711 MN - I1.880.735.657 MN - I3.50.625 MS - Profound inattention by individuals to their own health and hygiene. HN - 2019 MH - Sevoflurane UI - D000077149 MN - D2.355.601.810 MN - D2.455.526.510.717 MS - A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION. HN - 2019 (1975) MH - Shared Governance, Nursing UI - D000077772 MN - E5.599.645.500 MN - N2.360.680.490.500 MN - N2.360.740.523.500 MN - N4.452.921 MS - Model of nursing practice with shared decision processes designed to integrate core values and beliefs that professional practice embraces, as a means of achieving quality care. HN - 2019 MH - Shellfish Proteins UI - D000078582 MN - D12.776.256.472.750 MN - G7.203.300.428.472.750 MN - G7.203.300.600.625.750 MN - G7.203.300.600.875.700.500 MN - J2.500.428.472.750 MN - J2.500.600.625.750 MN - J2.500.600.875.700.500 MS - Proteins found in SHELLFISH. HN - 2019 MH - Silybin UI - D000077385 MN - D3.383.663.283.266.450.268.777.500 MN - D3.633.100.150.266.450.268.777.500 MS - The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers. HN - 2019 (2002) MH - Simendan UI - D000077464 MN - D2.442.288.610 MN - D3.383.710.802 MS - A hydrazone and pyridazine derivative; the levo-form is a phosphodiesterase III inhibitor, calcium-sensitizing agent, and inotropic agent that is used in the treatment of HEART FAILURE. HN - 2019 (1992) MH - Sitting Position UI - D000077708 MN - G11.427.695.575 HN - 2019; use Posture (2006-2018) MH - Sleep, Slow-Wave UI - D000077310 MN - F2.830.855.796.835 MN - G11.561.803.754.835 MS - A stage of sleep characterized by synchronized wave activity as observed by ELECTROENCEPHALOGRAM; the waves exhibit a frequency of 0.5 to 2 Hz, and a peak-to-peak amplitude greater than 75 microvolts. HN - 2019; use SLEEP 1998-2018 MH - Sleepiness UI - D000077260 MN - C23.888.900 MS - Compelling urge to sleep. HN - 2019 FX - Sleep MH - Smoking Cessation Agents UI - D000077444 MN - D27.505.954.810 MS - Substances that facilitate the cessation of tobacco smoking. HN - 2019 FX - Tobacco Use Cessation Devices MH - Societies, Veterinary UI - D000077923 MN - N3.540.828.919 MS - Organizations having institutional membership limited to veterinarians and veterinary institutions. HN - 2019 MH - Sodium Citrate UI - D000077559 MN - D2.241.81.901.434.249.875 MS - Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES. HN - 2019 (1996) MH - Sodium Sulfate Cotransporter UI - D000077003 MN - D12.776.157.530.450.74.875.500 MN - D12.776.157.530.450.250.878 MN - D12.776.157.530.450.625.390 MN - D12.776.157.530.937.929.500 MN - D12.776.543.585.450.74.875.500 MN - D12.776.543.585.450.250.883 MN - D12.776.543.585.450.625.437 MN - D12.776.543.585.937.963.500 MS - A multi-pass protein that consists of 13 transmembrane helices. It is expressed primarily by renal epithelial cells and functions as a co-transporter of sodium and sulfate, to mediate sulfate reabsorption in the kidney. HN - 2019 (1987) MH - Sodium-Glucose Transporter 2 Inhibitors UI - D000077203 MN - D27.505.519.936 MN - D27.505.696.422.750 MS - Compounds that inhibit SODIUM-GLUCOSE TRANSPORTER 2. They lower blood sugar by preventing the reabsorption of glucose by the kidney, and are used in the treatment of TYPE 2 DIABETES MELLITUS. HN - 2019 MH - Solanales UI - D000076666 MN - B1.650.940.800.575.912.250.908 MS - An order of flowering plants comprising tropical and temperate species, major crop plants such as potatoes, tomatoes, bell peppers, eggplants, tobacco, and the garden petunia. Its largest family is the SOLANACEAE. HN - 2019 MH - Sorafenib UI - D000077157 MN - D2.455.426.559.389.703.757 MN - D2.948.681.757 MN - D3.66.515.530.750 MN - D3.383.725.547.530.750 MS - A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy. HN - 2019 (2003) MH - Squamous Cell Carcinoma of Head and Neck UI - D000077195 MN - C4.557.470.200.400.565 MN - C4.588.443.177 MS - The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer. AN - coordinate IM with HEAD AND NECK NEOPLASMS (IM) HN - 2019 (2009) MH - Standing Position UI - D000078783 MN - G11.427.695.600 MS - Human position in which the body is held in an upright orthostatic position and supported only by the feet. HN - 2019 MH - Substandard Drugs UI - D000078742 MN - D26.894 MS - Drugs formulations that do not meet established standards. HN - 2019 MH - Sugammadex UI - D000077122 MN - D4.345.103.444.500 MN - D9.698.365.855.400.375.444.500 MS - A gamma-cyclodextrin that functions as a reversal agent for the neuromuscular blocker ROCURONIUM BROMIDE. HN - 2019 (2002) MH - Sulfanilamide UI - D000077145 MN - D2.65.884.725.885 MN - D2.92.146.807.885 MN - D2.886.590.700.725.885 MS - A short-acting sulfonamide used as an anti-infective agent. It has lower anti-bacterial activity than SULFAMETHOXAZOLE. HN - 2019 (1983) MH - Sulfate Transporters UI - D000076988 MN - D12.776.157.530.450.74.875 MN - D12.776.157.530.937.929 MN - D12.776.543.585.450.74.875 MN - D12.776.543.585.937.963 MS - Highly conserved families of transmembrane anion transporters that occur in both prokaryotes and eukaryotes. In humans, they are expressed by epithelial cells in a variety of tissues and participate in diverse physiologic functions such as cell motility and regulating the composition and acidity of body fluids. Some Slc13 family proteins function as sodium ion coupled co-transporters of sulfate and other anions. HN - 2019 MH - Sulfathiazole UI - D000077589 MN - D2.65.884.725.935.906 MN - D2.92.146.807.935.906 MN - D2.886.590.700.725.935.906 MN - D2.886.675.725.500 MN - D3.383.129.708.725.500 MS - A sulfathiazole compound that is used as a short acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine. HN - 2019 (1974) MH - Sunitinib UI - D000077210 MN - D3.383.129.578.823 MN - D3.633.100.473.877 MS - An indole and pyrrole derivative that inhibits VEGF-R2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA. HN - 2019 (2003) MH - Survivin UI - D000077022 MN - D12.644.360.75.437.625 MN - D12.776.167.576 MN - D12.776.220.600.450.495 MN - D12.776.476.75.437.625 MS - An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA. HN - 2019 MH - Sustainable Development UI - D000076502 MN - I1.655.500.608.700 MN - N6.230.80.900 MS - A process of change in which the exploitation of resources, the direction of investments, the orientation of technological development; and institutional change are all in harmony and enhance both current and future potential to meet human needs and aspirations. (http://www.un-documents.net/ocf-02.htm#I) HN - 2019; 1994-2018 see Conservation of Natural Resources MH - Syndemic UI - D000076603 MN - N6.850.490.937 MS - Synergistically-interacting health conditions producing excess disease occurrence in a population. HN - 2019 MH - Synthetic Drugs UI - D000076742 MN - D26.909 MS - Legal or illegal drugs created using SYNTHETIC CHEMISTRY TECHNIQUES. HN - 2019 MH - Systematic Review UI - D000078182 MN - V3.850 MS - A review of primary literature in health and health policy that attempts to identify, appraise, and synthesize all the empirical evidence that meets specified eligibility criteria to answer a given research question. Its conduct uses explicit methods aimed at minimizing bias in order to produce more reliable findings regarding the effects of interventions for prevention, treatment, and rehabilitation that can be used to inform decision making. HN - 2019 MH - Systematic Reviews as Topic UI - D000078202 MN - L1.178.682.759.575 MS - Works about a review of primary literature in health and health policy that attempt to identify, appraise, and synthesize all the empirical evidence that meets specified eligibility criteria to answer a given research question. Its conduct uses explicit methods aimed at minimizing bias in order to produce more reliable findings regarding the effects of interventions for prevention, treatment, and rehabilitation that can be used to inform decision making. HN - 2019 MH - Tamsulosin UI - D000077409 MN - D2.65.884.863 MN - D2.886.590.700.863 MS - A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA. HN - 2019 (1994) MH - Tandem Affinity Purification UI - D000078791 MN - E5.196.181.400.170.750 MS - A technique used to isolate specific interacting partners of MACROMOLECULAR COMPLEXES that have been assembled with a tagged component (bait) that interacts with other partners in the complex. The interacting bait component is labeled with a dual-affinity tag that allows for capture of the complex by IMMUNOPRECIPITATION, followed by purification of only the partners of the complex interacting with the bait by affinity chromatography. HN - 2019 MH - Tapentadol UI - D000077432 MN - D2.455.426.559.389.657.926 MS - An opioid analgesic, MU OPIOID RECEPTOR agonist, and noradrenaline reuptake inhibitor that is used in the treatment of moderate to severe pain, and of pain associated with DIABETIC NEUROPATHIES. HN - 2019 (2007) MH - Tazobactam UI - D000078142 MN - D2.65.589.99.750.687.750 MN - D2.886.108.750.687.750 MN - D2.886.590.841 MN - D3.633.100.300.750.687.750 MS - A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria. HN - 2019 (1985) MH - Telbivudine UI - D000077712 MN - D3.383.742.680.705.888 MN - D13.570.230.855.888 MN - D13.570.685.705.888 MS - A thymidine derivative and antiviral agent that inhibits DNA synthesis by HEPATITIS B VIRUS and is used for the treatment of CHRONIC HEPATITIS B. HN - 2019 (2004) MH - Telmisartan UI - D000077333 MN - D2.455.426.559.389.185.849 MN - D3.633.100.103.791 MS - A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION. HN - 2019 (1993) MH - Temozolomide UI - D000077204 MN - D2.925.200.500 MN - D3.383.129.308.240.500 MS - A dacarbazine derivative that is used as an alkylating antineoplastic agent for the treatment of MALIGNANT GLIOMA and MALIGNANT MELANOMA. HN - 2019 (1985) MH - Tenecteplase UI - D000077785 MN - D8.811.277.656.300.760.875.500 MN - D8.811.277.656.959.350.875.500 MN - D12.776.124.125.662.768.500 MS - A tissue plasminogen activator enzyme that acts as a fibrinolytic agent; it is used for the dissolution of blood clots, such as those that occur in acute MYOCARDIAL INFARCTION. HN - 2019 (1999) MH - Terbinafine UI - D000077291 MN - D2.455.426.559.847.638.953 MN - D4.615.638.953 MS - A naphthalene derivative that inhibits fungal SQUALENE EPOXIDASE and is used to treat DERMATOMYCOSES of the skin and nails. HN - 2019 (1984) MH - Terlipressin UI - D000077585 MN - D6.472.699.631.692.781.400.675 MN - D12.644.400.900.400.675 MN - D12.644.456.925.480.750 MN - D12.644.548.691.692.781.400.675 MN - D12.776.631.650.937.400.675 MS - An inactive peptide prodrug that is slowly converted in the body to lypressin. It is used to control bleeding of ESOPHAGEAL VARICES and for the treatment of HEPATORENAL SYNDROME. HN - 2019 (1976) MH - Therapeutic Alliance UI - D000078462 MN - F1.829.401.650.918 MN - F4.754.720.605 MN - F4.754.932 MS - A relational factor in counseling that includes three dimensions: goal consensus between counselor and client, collaboration on counseling-related tasks, and emotional bonding. It is referred to as the working alliance between a therapist and a client in psychotherapy and closely correlated with positive client outcomes. HN - 2019 MH - Thiamethoxam UI - D000077922 MN - D2.640.910 MN - D2.886.675.884 MN - D3.383.129.708.884 MN - D3.383.464.500 MN - D3.383.533.820 MS - A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide. HN - 2019 (2000) MH - Thymalfasin UI - D000077596 MN - D6.472.910.850.500 MN - D12.644.548.869.500 MN - D12.776.922.500 MS - A thymus hormone polypeptide found in thymosin fraction 5 (a crude thymus gland extract) but now produced by synthesis. It is used alone or with interferon as an immunomodulator for the treatment of CHRONIC HEPATITIS B and HEPATITIS C. Thymalfasin is also used for the treatment of chemotherapy-induced immunosuppression, and to enhance the efficacy of influenza and hepatitis B vaccines in immunocompromised patients. HN - 2019 (1980) MH - Thyroid Cancer, Papillary UI - D000077273 MN - C4.557.470.200.25.85.612 MN - C4.588.322.894.400 MN - C4.588.443.915.400 MN - C19.344.894.400 MN - C19.874.788.400 MS - An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer. AN - coordinate IM with THYROID NEOPLASMS (IM) HN - 2019 (2010) MH - Tiagabine UI - D000078308 MN - D3.66.566.500 MN - D3.383.621.566.500 MS - A nipecotic acid derivative that acts as a GABA uptake inhibitor and anticonvulsant agent. It is used in the treatment of EPILEPSY, for refractory PARTIAL SEIZURES. HN - 2019 (1989) MH - Ticagrelor UI - D000077486 MN - D3.633.100.759.590.138.806 MN - D13.570.583.138.806 MN - D13.570.800.96.815 MS - An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION. HN - 2019 (2005) MH - Tigecycline UI - D000078304 MN - D2.455.426.559.847.562.900.937 MN - D4.615.562.900.937 MS - A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia. HN - 2019 (1999) MH - Tinzaparin UI - D000078222 MN - D9.698.373.400.300.800 MS - A low-molecular-weight heparin with anticoagulant properties that is used in the prevention and treatment of VENOUS THROMBOEMBOLISM, and to prevent clotting during EXTRACORPOREAL CIRCULATION. HN - 2019 (1993) MH - Tirapazamine UI - D000077704 MN - D3.383.931.867 MS - A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation. HN - 2019 (1986) MH - Tirofiban UI - D000077466 MN - D12.125.72.50.875.875 MS - Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME. HN - 2019 (1993) MH - Tobramycin, Dexamethasone Drug Combination UI - D000078162 MN - D4.210.500.745.432.769.344.650 MN - D4.210.500.908.238.650 MN - D9.408.51.476.600.800.500 MN - D26.310.813 MS - A topical preparation of tobramycin and dexamethasone that is used for treating or preventing superficial bacterial infections of the eye. HN - 2019 MH - Tolcapone UI - D000077867 MN - D2.455.426.559.389.134.875 MN - D2.455.426.559.389.657.566.845 MN - D2.522.223.875 MN - D2.640.743.845 MS - A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated. HN - 2019 (1990) MH - Tolvaptan UI - D000077602 MN - D3.633.100.79.875 MS - A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency. HN - 2019 (1999) MH - Topiramate UI - D000077236 MN - D9.947.875.359.250.500 MN - D9.947.875.465.354.500 MS - A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss. HN - 2019 (1987) MH - Torsemide UI - D000077786 MN - D2.65.884.891 MN - D2.886.590.700.891 MN - D3.383.725.905 MS - A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION. HN - 2019 (1980) MH - Trabectedin UI - D000077606 MN - D3.383.246.619 MN - D3.633.100.531.820.781 MS - A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy. HN - 2019 (1996) MH - Traffic-Related Pollution UI - D000076764 MN - N6.850.460.685 MS - Contamination of the ENVIRONMENT by VEHICLE EMISSIONS. HN - 2019 FX - Vehicle Emissions MH - Triclabendazole UI - D000077682 MN - D3.633.100.103.925 MS - Benzimidazole antiplatyhelmintic agent that is used for the treatment of FASCIOLIASIS and PARAGONIMIASIS. HN - 2019 (1983) MH - Troglitazone UI - D000077288 MN - D2.886.675.933.750 MN - D3.383.129.708.933.750 MN - D3.383.663.283.240.612 MN - D3.633.100.150.240.612 MS - A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity. HN - 2019 (1988) MH - Tropisetron UI - D000077526 MN - D3.633.100.473.896 MS - An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting. HN - 2019 (1985) MH - Tuberous Sclerosis Complex 1 Protein UI - D000077004 MN - D12.644.360.925 MN - D12.776.476.932 MN - D12.776.624.776.766 MS - An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS. HN - 2019 (1997) MH - Tuberous Sclerosis Complex 2 Protein UI - D000077005 MN - D12.644.360.938 MN - D12.776.476.935 MN - D12.776.624.776.769 MS - An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN (TSC1) and other signaling factors to negatively regulate MTORC1 and affect cell growth and proliferation. It can also function as GTPASE-ACTIVATING PROTEIN (GAP) for RHEB GTPASE to activate mTORC1 independent of its role in the complex. Structurally, it interacts with TSC1 through its N-terminus, which also contains a leucine zipper and coiled-coil region. It also has multiple phosphorylation sites for different cell signaling kinases, a central coiled-coil region, a C-terminal GAP domain and CALMODULIN binding domain. Mutations in the TSC2 gene are associated with TUBEROUS SCLEROSIS. HN - 2019 (1994) MH - UNESCO UI - D000076892 MN - N3.540.514.718.400 MS - An operating body of the UNITED NATIONS, responsible for coordinating international cooperation in education, science, culture and communication. AN - CATALOGER: Use NAF entry HN - 2019; was UNITED NATIONS 1980-2018; INTERNATIONAL ORGANIZATIONS 1978-1979 MH - Urinary Bladder, Underactive UI - D000077295 MN - C12.777.829.893 MN - C13.351.968.829.867 MN - C23.888.942.343.790 MS - Symptom of underactive detrusor muscle of the URINARY BLADDER that contracts with abnormally reduced strength or duration resulting in an incomplete and/or prolonged bladder emptying. HN - 2019 FX - Urinary Retention MH - Vaccinology UI - D000078782 MN - H2.403.894 MS - Branch of medicine concerned with the development of vaccines to control disease by identifying genetic and other mechanisms and pathways that determine immune responses, and thereby provide new candidate vaccine approaches. HN - 2019 MH - Valacyclovir UI - D000077483 MN - D3.633.100.759.758.399.454.250.650 MS - A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES. HN - 2019 (1994) MH - Valganciclovir UI - D000077562 MN - D3.633.100.759.758.399.454.250.300.500 MS - A ganciclovir prodrug and antiviral agent that is used to treat CYTOMEGALOVIRUS RETINITIS in patients with AIDS, and for the prevention of CYTOMEGALOVIRUS INFECTIONS in organ transplant recipients who have received an organ from a CMV-positive donor. HN - 2019 (1999) MH - Vemurafenib UI - D000077484 MN - D2.65.884.919 MN - D2.886.590.700.919 MN - D3.633.100.473.936 MS - An indole sulfonamide compound and inhibitor of BRAF KINASES that is used for the treatment of unresectable or metastatic MELANOMA. HN - 2019 (2010) MH - Ventilation-Perfusion Scan UI - D000076665 MN - E1.370.350.710.900 MN - E1.370.384.730.900 MN - E1.370.386.700.963 MS - A two-part radionuclide imaging that measures VENTILATION-PERFUSION RATIO of the lungs often used to investigate PULMONARY EMBOLISM. Image acquisitions may be performed using various combinations of gamma camera, PET and SPECT scanning techniques. HN - 2019 MH - Verteporfin UI - D000077362 MN - D3.383.129.578.840.500.940 MN - D3.633.400.909.500.940 MN - D4.345.783.500.940 MS - A benzoporphyrin derivative that is used in PHOTOCHEMOTHERAPY to treat wet type MACULAR DEGENERATION. HN - 2019 (1996) MH - Vildagliptin UI - D000077597 MN - D2.626.943 MN - D3.383.773.953 MS - A pyrrolidine-carbonitrile derivative and potent inhibitor of DIPEPTIDYL PEPTIDASE 4 that is used in the treatment of TYPE 2 DIABETES MELLITUS. HN - 2019 (2005) MH - Vinorelbine UI - D000077235 MN - D3.132.436.681.827.915 MN - D3.633.100.473.402.681.827.915 MS - A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES. HN - 2019 (1981) MH - Vorinostat UI - D000077337 MN - D2.65.199.960 MN - D2.92.146.113.960 MN - D2.92.570.394.690 MN - D2.241.511.372.690 MS - A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME. HN - 2019 (1998) MH - Vortioxetine UI - D000078784 MN - D3.383.606.990 MS - A piperazine derivative that acts as a serotonin reuptake inhibitor, as a 5-HT3 receptor antagonist, and 5-HT1A receptor agonist. It is used for the treatment of anxiety and depression. HN - 2019 (2011) MH - Web Archive UI - D000078942 MN - V2.260.700 MS - Collection of preserved web pages. AN - This heading is used as a Publication Type. Works on Web Archives as a subject are indexed under the main the heading WEB ARCHIVES AS TOPIC. INDEXER: Do not use HN - 2019 MH - Web Archives as Topic UI - D000078882 MN - L1.224.230.110.500.875 MS - Works about collections of preserved web pages. AN - do not confuse with the Publication Type WEB ARCHIVE HN - 2019 MH - Wool Fiber UI - D000078623 MN - J1.637.836.649 MS - Filament, thread, or yarn produced from WOOL. AN - WOOL is also available HN - 2019 FX - Wool MH - Workforce UI - D000078329 MN - N4.452.525 MS - The number of people working or available for work or service. AN - coordinate with specific discipline, occupation, service or program if pertinent; HEALTH WORKFORCE is also available HN - 2019(1968) MH - Wortmannin UI - D000077191 MN - D4.210.500.54.79.129.891 MS - An androstadiene metabolite produced by the fungi PENICILLIUM funiculosum that inhibits PHOSPHATIDYLINOSITOL-3-KINASES and alloantigen-specific activation of T-LYMPHOCYTES in human tumor cell lines. It is widely used in CELL BIOLOGY research and has broad therapeutic potential. HN - 2019 (1974) MH - Zoledronic Acid UI - D000077211 MN - D2.705.429.500.942 MN - D3.383.129.308.990 MS - An imidodiphosphonate and inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS. HN - 2019 (1994) MH - Zolpidem UI - D000077334 MN - D3.383.725.971 MS - An imidazopyridine derivative and short acting GABA-A receptor agonist that is used for the treatment of INSOMNIA. HN - 2019 (1985) MH - Zonisamide UI - D000078305 MN - D2.65.884.987 MN - D2.886.590.700.987 MN - D3.383.129.385.825 MS - A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization. HN - 2019 (1980)